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Medicine

D-Index
83
Citations
22766
World Ranking
15717
National Ranking
7910

Overview

Thomas L. Clemens is affiliated with the United States Department of Veterans Affairs in the United States. Their primary research focus lies in the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with 34 and 20 publications respectively. These contributions extend into subfields such as Molecular Biology, Genetics, Surgery, Rheumatology, and Physiology.

Their work extensively covers topics that include Bone Metabolism and Diseases, Heterotopic Ossification and Related Conditions, Cancer, Stress, Anesthesia, and Immune Response, Nerve Injury and Regeneration, Mesenchymal Stem Cell Research, Bone Fractures and Treatments, and Tendon Structure and Treatment.

Thomas L. Clemens has published in several scientific venues. Frequent publication venues include Proceedings of the National Academy of Sciences, bioRxiv (Cold Spring Harbor Laboratory), Cell Reports, Nature Communications, and Science Advances.

Key recent papers authored or co-authored by Clemens include:

  • A Neurotrophic Mechanism Directs Sensory Nerve Transit in Cranial Bone (2020, Cell Reports)
  • NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma (2021, Nature Communications)
  • NGF-p75 signaling coordinates skeletal cell migration during bone repair (2022, Science Advances)
  • Spatial transcriptomics reveals a role for sensory nerves in preserving cranial suture patency through modulation of BMP/TGF-β signaling (2021, Proceedings of the National Academy of Sciences)
  • A specialized metabolic pathway partitions citrate in hydroxyapatite to impact mineralization of bones and teeth (2022, Proceedings of the National Academy of Sciences)

Collaborations form an important aspect of Clemens's research, with frequent co-authors including Aaron W. James, Qizhi Qin, Robert J. Tower, Stefano Negri, and Zhao Li.

Best Publications

  • Increased skin pigment reduces the capacity of skin to synthesise vitamin D3.

    T.L. Clemens;S.L. Henderson;J.S. Adams;M.F. Holick

  • Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

    Keertik Fulzele;Ryan C. Riddle;Douglas J. DiGirolamo;Xuemei Cao

  • The hypoxia-inducible factor α pathway couples angiogenesis to osteogenesis during skeletal development

    Ying Wang;Chao Wan;Lianfu Deng;Ximeng Liu

  • Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation.

    Ashok. K Bhalla;Edward P Amento;Thomas L Clemens;Michael F Holick

  • Osteoblast-specific Knockout of the Insulin-like Growth Factor (IGF) Receptor Gene Reveals an Essential Role of IGF Signaling in Bone Matrix Mineralization

    Mei Zhang;Shouhong Xuan;Mary L. Bouxsein;Dietrich von Stechow

  • Oxidative Stress Induces Vascular Calcification Through Modulation of the Osteogenic Transcription Factor Runx2 by AKT Signaling

    Chang Hyun Byon;Amjad Javed;Qun Dai;John C. Kappes

  • Skeletal disease in primary hyperparathyroidism.

    Shonni J. Silverberg;Elizabeth Shane;Luz de la Cruz;David W. Dempster

  • Essential Role of β-Catenin in Postnatal Bone Acquisition

    Sheri L. Holmen;Cassandra R. Zylstra;Aditi Mukherjee;Robert E. Sigler

  • Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

    Dongsu Park;Joel A. Spencer;Bong Ihn Koh;Tatsuya Kobayashi

  • Activation of the hypoxia-inducible factor-1α pathway accelerates bone regeneration

    Chao Wan;Shawn R. Gilbert;Ying Wang;Xuemei Cao

  • Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation.

    Guisheng Zhao;Marie Claude Monier-Faugere;Moises Chris Langub;Zhaopo Geng

  • Vitamin-D Synthesis and Metabolism after Ultraviolet Irradiation of Normal and Vitamin-D-Deficient Subjects

    John S. Adams;John S. Adams;Thomas L. Clemens;Thomas L. Clemens;John A. Parrish;John A. Parrish;Michael F. Holick;Michael F. Holick

  • Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9.

    Jared C. Robins;Nagako Akeno;Aditi Mukherjee;Ravi R. Dalal

  • The osteoblast: An insulin target cell controlling glucose homeostasis

    Thomas L Clemens;Gerard Karsenty

  • Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice.

    Robert S. Weinstein;Chao Wan;Qinglan Liu;Ying Wang

  • Vitamin D absorption in healthy subjects and in patients with intestinal malabsorption syndromes

    C W Lo;P W Paris;T L Clemens;J Nolan

  • Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism

    Yong Fan;Ram K. Menon;Pinchas Cohen;David Hwang

  • Interaction of 1,25-Dihydroxyvitamin-D3 with Keratinocytes and Fibroblasts from Skin of Normal Subjects and a Subject with Vitamin-D-Dependent Rickets, Type II: A Model for Study of the Mode of Action of 1,25-Dihydroxyvitamin D3*

    Thomas L. Clemens;Thomas L. Clemens;Thomas L. Clemens;John S. Adams;John S. Adams;John S. Adams;Noboru Horiuchi;Noboru Horiuchi;Noboru Horiuchi;Barbara A. Gilchrest;Barbara A. Gilchrest;Barbara A. Gilchrest

  • Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice

    Mahendra D. Mavalli;Douglas J. DiGirolamo;Yong Fan;Ryan C. Riddle

  • Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice

    Xing Shen;Chao Wan;Girish Ramaswamy;Mahendra Mavalli

Frequent Co-Authors

Michael F. Holick
Michael F. Holick Boston University
John S. Adams
John S. Adams University of California, Los Angeles
Stuart J. Frank
Stuart J. Frank University of Alabama at Birmingham
John P. Bilezikian
John P. Bilezikian Columbia University
James A. Fagin
James A. Fagin Memorial Sloan Kettering Cancer Center
Elizabeth Shane
Elizabeth Shane Columbia University
Clifford J. Rosen
Clifford J. Rosen Maine Medical Center
Charles R. Farber
Charles R. Farber University of Virginia
David W. Dempster
David W. Dempster Columbia University
Bart O. Williams
Bart O. Williams Van Andel Institute

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