What is he best known for?
The fields of study he is best known for:
His primary scientific interests are in Pathology, Frontotemporal lobar degeneration, Amyotrophic lateral sclerosis, Alpha-synuclein and Ubiquitin.
His work in Pathology addresses subjects such as Immunoblot Analysis, which are connected to disciplines such as Degenerative disease, Hippocampal formation, Alternative splicing and Frontotemporal dementia.
His Amyotrophic lateral sclerosis research is multidisciplinary, relying on both Neurite, Molecular biology, Motor neuron and Phosphorylation.
Takashi Nonaka interconnects UBQLN2, Cellular differentiation, Charged multivesicular body protein 2B, TARDBP and Anatomy in the investigation of issues within Motor neuron.
His research in Alpha-synuclein intersects with topics in Fibril, Dementia with Lewy bodies, Intracellular and Pharmacology.
His Ubiquitin study is focused on Biochemistry in general.
His most cited work include:
- TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis (1717 citations)
- Prion-like spreading of pathological α-synuclein in brain (489 citations)
- Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. (452 citations)
What are the main themes of his work throughout his whole career to date?
Takashi Nonaka mostly deals with Cell biology, Biochemistry, Intracellular, Pathology and Molecular biology.
His Cell biology research includes elements of Fibril, In vitro, Ubiquitin and Alpha-synuclein.
Takashi Nonaka combines subjects such as Dementia with Lewy bodies and Neurite with his study of Fibril.
His study in Frontotemporal lobar degeneration, Amyotrophic lateral sclerosis, Frontotemporal dementia, Immunohistochemistry and Corticobasal degeneration is carried out as part of his studies in Pathology.
His Frontotemporal lobar degeneration study also includes
- Phosphorylation, which have a strong connection to Inclusion bodies,
- Neurodegeneration which connect with Mutant.
The study incorporates disciplines such as Phenotype, Motor neuron, Antibody and Prion protein in addition to Amyotrophic lateral sclerosis.
He most often published in these fields:
- Cell biology (35.86%)
- Biochemistry (21.38%)
- Intracellular (17.24%)
What were the highlights of his more recent work (between 2015-2021)?
- Cell biology (35.86%)
- Protein aggregation (9.66%)
- In vitro (11.72%)
In recent papers he was focusing on the following fields of study:
His scientific interests lie mostly in Cell biology, Protein aggregation, In vitro, Neurodegeneration and Fibril.
His Cell biology research is multidisciplinary, incorporating elements of α synuclein, Alpha-synuclein, Pathogenesis and In vivo.
His biological study deals with issues like Ubiquitin, which deal with fields such as Phosphorylation, Mutation and Mutant.
His study in In vitro is interdisciplinary in nature, drawing from both Cell, Peptide sequence and Amyloid.
His Neurodegeneration research integrates issues from Phenotype, Frontotemporal lobar degeneration, Intracellular and Ataxin.
The Fibril study combines topics in areas such as Dementia with Lewy bodies and Neurite.
Between 2015 and 2021, his most popular works were:
- Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau (103 citations)
- Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils. (51 citations)
- The Effect of Fragmented Pathogenic α-Synuclein Seeds on Prion-like Propagation (48 citations)
In his most recent research, the most cited papers focused on:
The scientist’s investigation covers issues in Neurodegeneration, Fibril, Protein aggregation, Amyloid and Biochemistry.
The various areas that Takashi Nonaka examines in his Neurodegeneration study include Cerebellum, Dentate gyrus, Hippocampal formation, Frontotemporal dementia and Anterior Horn Cell.
His research integrates issues of Neurite and Function in his study of Fibril.
His work deals with themes such as Mutation, Ubiquitin, Lysosome and Mutant, which intersect with Protein aggregation.
His research in Ubiquitin intersects with topics in Casein Kinase Idelta, Casein kinase 1, Molecular biology, Intracellular and Phosphorylation.
His research is interdisciplinary, bridging the disciplines of Frontotemporal lobar degeneration and Biochemistry.
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