2026 Takashi Nonaka: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	58	12983	11945	899	843	158	16132

Overview

Takashi Nonaka is affiliated with the Tokyo Metropolitan Institute of Medical Science in Japan. Their research primarily spans the field of Medicine, with a particular focus on Neurology, Physiology, and Molecular Biology. Their contributions also extend to Cellular and Molecular Neuroscience and Pulmonary and Respiratory Medicine.

Their research topics cover a range of neurological disorders and mechanisms, including:

Alzheimer's disease research and treatments
Parkinson's Disease Mechanisms and Treatments
Amyotrophic Lateral Sclerosis Research
Neuroinflammation and Neurodegeneration Mechanisms
Prion Diseases and Protein Misfolding
Neurological diseases and metabolism
Dementia and Cognitive Impairment Research

Nonaka has published extensively with notable papers, such as:

"Tunnelling nanotubes between neuronal and microglial cells allow bi-directional transfer of α-Synuclein and mitochondria" (2023) in Cell Death and Disease
"α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes" (2021) in PLoS Biology
"α-synuclein strains that cause distinct pathologies differentially inhibit proteasome" (2020) in eLife
"Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C" (2024) in Nature
"Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body" (2022) in Scientific Reports

The scientist frequently collaborates with several coauthors, including:

Masato Hasegawa
Genjiro Suzuki
Chiara Zurzolo
Masato Hosokawa
Masami Masuda-Suzukake

Nonaka's work is published in a variety of scientific venues, with several papers appearing in:

bioRxiv (Cold Spring Harbor Laboratory)
Brain
Neuroscience Research
Cell Death and Disease
PLoS Biology

Best Publications

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Tetsuaki Arai;Masato Hasegawa;Haruhiko Akiyama;Kenji Ikeda

3532
Citations
Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Masato Hasegawa;Tetsuaki Arai;Takashi Nonaka;Fuyuki Kametani

778
Citations
Drug screening for ALS using patient-specific induced pluripotent stem cells.

Naohiro Egawa;Shiho Kitaoka;Kayoko Tsukita;Motoko Naitoh

661
Citations
Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains

Takashi Nonaka;Masami Masuda-Suzukake;Tetsuaki Arai;Tetsuaki Arai;Yoko Hasegawa

517
Citations
Small Molecule Inhibitors of α-Synuclein Filament Assembly†

Masami Masuda;Nobuyuki Suzuki;Sayuri Taniguchi;Takayuki Oikawa

509
Citations
Phosphorylated α-Synuclein Is Ubiquitinated in α-Synucleinopathy Lesions

Masato Hasegawa;Hideo Fujiwara;Takashi Nonaka;Koichi Wakabayashi

477
Citations
Seeded Aggregation and Toxicity of α-Synuclein and Tau: CELLULAR MODELS OF NEURODEGENERATIVE DISEASES*

Takashi Nonaka;Sayuri T. Watanabe;Takeshi Iwatsubo;Masato Hasegawa

437
Citations
Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43

Takashi Nonaka;Fuyuki Kametani;Tetsuaki Arai;Haruhiko Akiyama

392
Citations
Supramolecular structure of the Shigella type III secretion machinery: the needle part is changeable in length and essential for delivery of effectors

Koichi Tamano;Shin‐Ichi Aizawa;Eisaku Katayama;Takashi Nonaka

308
Citations
Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS

Yuki Inukai;Takashi Nonaka;Tetsuaki Arai;Mari Yoshida

248
Citations
Identification of amino‐terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration

Tetsuaki Arai;Kenji Ikeda;Haruhiko Akiyama;Takashi Nonaka

222
Citations
Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau

Sayuri Taniguchi-Watanabe;Sayuri Taniguchi-Watanabe;Tetsuaki Arai;Fuyuki Kametani;Takashi Nonaka

186
Citations
Ubiquitination of α-Synuclein†

Takashi Nonaka;Takeshi Iwatsubo;Masato Hasegawa

176
Citations
Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells.

Takashi Nonaka;Tetsuaki Arai;Emanuele Buratti;Francisco E. Baralle

167
Citations
Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models

Makiko Yamashita;Takashi Nonaka;Tetsuaki Arai;Fuyuki Kametani

159
Citations
Conversion of Wild-type α-Synuclein into Mutant-type Fibrils and Its Propagation in the Presence of A30P Mutant

Motokuni Yonetani;Takashi Nonaka;Masami Masuda;Yuki Inukai

148
Citations
Identification of casein kinase-1 phosphorylation sites on TDP-43.

Fuyuki Kametani;Takashi Nonaka;Takehiro Suzuki;Tetsuaki Arai

142
Citations
C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

Jodi Meyerowitz;Sarah J. Parker;Laura J. Vella;Dominic C. H. Ng

137
Citations
Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1δ Triggers Mislocalization and Accumulation of TDP-43

Takashi Nonaka;Genjiro Suzuki;Yoshinori Tanaka;Fuyuki Kametani

134
Citations
Frontotemporal dementia with Pick-type histology associated with Q336R mutation in the tau gene.

S. M. Pickering‐Brown;M. Baker;T. Nonaka;K. Ikeda

123
Citations