His primary scientific interests are in Pathology, Frontotemporal lobar degeneration, Amyotrophic lateral sclerosis, Alpha-synuclein and Ubiquitin. His work in Pathology addresses subjects such as Immunoblot Analysis, which are connected to disciplines such as Degenerative disease, Hippocampal formation, Alternative splicing and Frontotemporal dementia. His Amyotrophic lateral sclerosis research is multidisciplinary, relying on both Neurite, Molecular biology, Motor neuron and Phosphorylation.
Takashi Nonaka interconnects UBQLN2, Cellular differentiation, Charged multivesicular body protein 2B, TARDBP and Anatomy in the investigation of issues within Motor neuron. His research in Alpha-synuclein intersects with topics in Fibril, Dementia with Lewy bodies, Intracellular and Pharmacology. His Ubiquitin study is focused on Biochemistry in general.
Takashi Nonaka mostly deals with Cell biology, Biochemistry, Intracellular, Pathology and Molecular biology. His Cell biology research includes elements of Fibril, In vitro, Ubiquitin and Alpha-synuclein. Takashi Nonaka combines subjects such as Dementia with Lewy bodies and Neurite with his study of Fibril.
His study in Frontotemporal lobar degeneration, Amyotrophic lateral sclerosis, Frontotemporal dementia, Immunohistochemistry and Corticobasal degeneration is carried out as part of his studies in Pathology. His Frontotemporal lobar degeneration study also includes
His scientific interests lie mostly in Cell biology, Protein aggregation, In vitro, Neurodegeneration and Fibril. His Cell biology research is multidisciplinary, incorporating elements of α synuclein, Alpha-synuclein, Pathogenesis and In vivo. His biological study deals with issues like Ubiquitin, which deal with fields such as Phosphorylation, Mutation and Mutant.
His study in In vitro is interdisciplinary in nature, drawing from both Cell, Peptide sequence and Amyloid. His Neurodegeneration research integrates issues from Phenotype, Frontotemporal lobar degeneration, Intracellular and Ataxin. The Fibril study combines topics in areas such as Dementia with Lewy bodies and Neurite.
The scientist’s investigation covers issues in Neurodegeneration, Fibril, Protein aggregation, Amyloid and Biochemistry. The various areas that Takashi Nonaka examines in his Neurodegeneration study include Cerebellum, Dentate gyrus, Hippocampal formation, Frontotemporal dementia and Anterior Horn Cell. His research integrates issues of Neurite and Function in his study of Fibril.
His work deals with themes such as Mutation, Ubiquitin, Lysosome and Mutant, which intersect with Protein aggregation. His research in Ubiquitin intersects with topics in Casein Kinase Idelta, Casein kinase 1, Molecular biology, Intracellular and Phosphorylation. His research is interdisciplinary, bridging the disciplines of Frontotemporal lobar degeneration and Biochemistry.
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Tetsuaki Arai;Masato Hasegawa;Haruhiko Akiyama;Kenji Ikeda.
Biochemical and Biophysical Research Communications (2006)
Prion-like spreading of pathological α-synuclein in brain
Masami Masuda-Suzukake;Takashi Nonaka;Masato Hosokawa;Takayuki Oikawa.
Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Masato Hasegawa;Tetsuaki Arai;Takashi Nonaka;Fuyuki Kametani.
Annals of Neurology (2008)
Drug screening for ALS using patient-specific induced pluripotent stem cells.
Naohiro Egawa;Shiho Kitaoka;Kayoko Tsukita;Motoko Naitoh.
Science Translational Medicine (2012)
Phosphorylated α-Synuclein Is Ubiquitinated in α-Synucleinopathy Lesions
Masato Hasegawa;Hideo Fujiwara;Takashi Nonaka;Koichi Wakabayashi.
Journal of Biological Chemistry (2002)
Small Molecule Inhibitors of α-Synuclein Filament Assembly†
Masami Masuda;Nobuyuki Suzuki;Sayuri Taniguchi;Takayuki Oikawa.
Seeded Aggregation and Toxicity of α-Synuclein and Tau: CELLULAR MODELS OF NEURODEGENERATIVE DISEASES*
Takashi Nonaka;Sayuri T. Watanabe;Takeshi Iwatsubo;Masato Hasegawa.
Journal of Biological Chemistry (2010)
Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains
Takashi Nonaka;Masami Masuda-Suzukake;Tetsuaki Arai;Tetsuaki Arai;Yoko Hasegawa.
Cell Reports (2013)
Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43
Takashi Nonaka;Fuyuki Kametani;Tetsuaki Arai;Haruhiko Akiyama.
Human Molecular Genetics (2009)
Supramolecular structure of the Shigella type III secretion machinery: the needle part is changeable in length and essential for delivery of effectors
Koichi Tamano;Shin‐Ichi Aizawa;Eisaku Katayama;Takashi Nonaka.
The EMBO Journal (2000)
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