Ornella Rossetto mainly focuses on Biochemistry, Neurotoxin, Synaptobrevin, Synaptic vesicle and Clostridium botulinum. Her research brings together the fields of Aplysia and Biochemistry. Her Neurotoxin study combines topics in areas such as Botulinum toxin, Surgery, Biophysics, Serotype and Pharmacology.
Her work deals with themes such as Molecular biology, Botulism, Ganglioside binding, Synaptic vesicle docking and Cell biology, which intersect with Synaptobrevin. In her work, Vesicle-associated membrane protein is strongly intertwined with Syntaxin, which is a subfield of Cell biology. Her research integrates issues of Integral membrane protein, Protease, Acetylcholine, Clostridium tetani and Neuromuscular junction in her study of Synaptic vesicle.
Her primary scientific interests are in Biochemistry, Synaptic vesicle, Neurotoxin, Cell biology and Pharmacology. Her work carried out in the field of Biochemistry brings together such families of science as Botulism and Biophysics. She interconnects Neurotransmitter, Exocytosis, Acetylcholine, Thioredoxin and Neuromuscular junction in the investigation of issues within Synaptic vesicle.
Her Neurotoxin study combines topics from a wide range of disciplines, such as Cholinergic, Phospholipase A2, Clostridium botulinum, Clostridium tetani and Metalloproteinase. Her research investigates the link between Cell biology and topics such as Vesicle that cross with problems in Endocytosis and Lysophospholipids. Her Pharmacology study also includes fields such as
Botulism, Neuroscience, Pharmacology, Biochemistry and Peripheral nerve are her primary areas of study. The Botulism study combines topics in areas such as Microbial toxins, Clostridium botulinum, Proteolysis and Syntaxin. The Cholinergic, Excitatory postsynaptic potential, Reinnervation and Electrophysiology research she does as part of her general Neuroscience study is frequently linked to other disciplines of science, such as Peripheral, therefore creating a link between diverse domains of science.
Her research in Pharmacology intersects with topics in Botulinum neurotoxin, Toxicity and Neuronal toxicity. Her Biochemistry study frequently draws connections to adjacent fields such as Redox. Her Thioredoxin research incorporates elements of Infant Botulism, Hsp90, Synaptic vesicle and Reductase.
Ornella Rossetto mainly investigates Botulism, Cytosol, Biochemistry, Pharmacology and Neuroscience. Her Botulism research is multidisciplinary, incorporating elements of Botulinum neurotoxin and Microbial toxins. Her Botulinum neurotoxin research includes themes of Computational biology and Clostridium botulinum.
Thioredoxin, Intracellular and Internalization are the core of her Biochemistry study. Her Thioredoxin research includes elements of Synaptic vesicle, Reductase and Geldanamycin. Her studies in Neuroscience integrate themes in fields like Molecular mechanism and Peripheral nerve.
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Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
Giampietro G. Schiavo;Fabio Benfenati;Bernard Poulain;Ornella Rossetto.
Nature (1992)
Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E.
G Schiavo;O Rossetto;S Catsicas;P Polverino de Laureto.
Journal of Biological Chemistry (1993)
Botulinum neurotoxins: genetic, structural and mechanistic insights
Ornella Rossetto;Marco Pirazzini;Cesare Montecucco.
Nature Reviews Microbiology (2014)
Long-Distance Retrograde Effects of Botulinum Neurotoxin A
Flavia Antonucci;Chiara Rossi;Laura Gianfranceschi;Ornella Rossetto.
The Journal of Neuroscience (2008)
Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin
G. Schiavo;C. C. Shone;O. Rossetto;F. C. G. Alexander.
Journal of Biological Chemistry (1993)
Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc.
G. Schiavo;B. Poulain;O. Rossetto;F. Benfenati.
The EMBO Journal (1992)
Botulinum neurotoxins are zinc proteins.
G Schiavo;O Rossetto;A Santucci;B.R. DasGupta.
Journal of Biological Chemistry (1992)
Tetanus and botulinum neurotoxins: mechanism of action and therapeutic uses
Rossella Pellizzari;Ornella Rossetto;Giampietro Schiavo;Cesare Montecucco.
Philosophical Transactions of the Royal Society B (1999)
Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology.
Marco Pirazzini;Ornella Rossetto;Roberto Eleopra;Cesare Montecucco.
Pharmacological Reviews (2017)
VAMP-2 and cellubrevin are expressed in pancreatic beta-cells and are essential for Ca(2+)-but not for GTP gamma S-induced insulin secretion.
R. Regazzi;C. B. Wollheim;Jochen Lang;J.-M. Theler.
The EMBO Journal (1995)
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