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Biology and Biochemistry
UK
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
94
Citations
32345
World Ranking
2012
National Ranking
128

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award

Overview

Giampietro Schiavo is affiliated with University College London in the United Kingdom and has a research portfolio spanning biochemistry, genetics, molecular biology, medicine, and neuroscience. Their work has contributed significantly to understanding neurodegenerative disorders and molecular mechanisms within cellular neuroscience.

The main fields of study for this researcher include Biochemistry, Genetics and Molecular Biology with 82 publications, Medicine with 75, and Neuroscience with 69. Subfields emphasize Cellular and Molecular Neuroscience (54 publications), Molecular Biology (53), Neurology (42), Cell Biology (20), and Genetics (16).

Research topics reflect a focus on neurological diseases and molecular mechanisms, specifically:

  • Amyotrophic Lateral Sclerosis Research
  • Nerve injury and regeneration
  • Neuroscience and Neuropharmacology Research
  • Neurogenetic and Muscular Disorders Research
  • RNA Research and Splicing
  • Mitochondrial Function and Pathology
  • Alzheimer's disease research and treatments

Frequent publication venues for Schiavo's work include bioRxiv (Cold Spring Harbor Laboratory) with 25 publications, Toxicon with 8, Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature with 7, Journal of Visualized Experiments with 4, and Alzheimer's & Dementia with 4 publications.

Schiavo has collaborated extensively with several researchers, among the most frequent co-authors are:

  • James N. Sleigh (38 joint publications)
  • Andrew P. Tosolini (21 joint publications)
  • Elizabeth Fisher (14 joint publications)
  • Elena R. Rhymes (14 joint publications)
  • David Villarroel-Campos (14 joint publications)

Significant papers authored or co-authored by Giampietro Schiavo include:

  • TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A, 2022, Nature
  • FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention, 2020, Nucleic Acids Research
  • Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes, 2020, Cell Reports
  • Potential human transmission of amyloid β pathology: surveillance and risks, 2020, The Lancet Neurology
  • FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation, 2021, Science Advances

Best Publications

  • Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

    Giampietro G. Schiavo;Fabio Benfenati;Bernard Poulain;Ornella Rossetto

  • Neurotoxins Affecting Neuroexocytosis

    Giampietro Schiavo;Michela Matteoli;Cesare Montecucco

  • Mutations in Dynein Link Motor Neuron Degeneration to Defects in Retrograde Transport

    Majid Hafezparast;Rainer Klocke;Christiana Ruhrberg;Andreas Marquardt

  • Structure and function of tetanus and botulinum neurotoxins

    Cesare Montecucco;Giampietro Schiavo

  • Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection

    Andreas Pichlmair;Andreas Pichlmair;Oliver Schulz;Choon-Ping Tan;Jan Rehwinkel

  • Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E.

    G Schiavo;O Rossetto;S Catsicas;P Polverino de Laureto

  • Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds

    Giampietro Schiavo;Annalisa Santucci;Bibhuti R. Dasgupta;Prashant P. Mehta

  • Rab5 and Rab7 Control Endocytic Sorting along the Axonal Retrograde Transport Pathway

    Katrin Deinhardt;Sara Salinas;Carole Verastegui;Rose Watson

  • Deficits in axonal transport precede ALS symptoms in vivo.

    Lynsey G. Bilsland;Erik Sahai;Gavin Kelly;Matthew Golding

  • Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin

    G. Schiavo;C. C. Shone;O. Rossetto;F. C. G. Alexander

  • Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses

    Giampietro Schiavo;Gudrun Stenbeck;James E. Rothman;Thomas H. Söllner

  • Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin

    Giampietro Schiavo;Qu Ming Gu;Glenn D. Prestwich;Thomas H. Söllner

  • Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy

    Jose Norberto S. Vargas;Jose Norberto S. Vargas;Chunxin Wang;Eric Bunker;Ling Hao

  • Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc.

    G. Schiavo;B. Poulain;O. Rossetto;F. Benfenati

  • Tetanus and botulinum neurotoxins: mechanism of action and therapeutic uses

    Rossella Pellizzari;Ornella Rossetto;Giampietro Schiavo;Cesare Montecucco

  • Botulinum neurotoxins are zinc proteins.

    G Schiavo;O Rossetto;A Santucci;B.R. DasGupta

  • Botulinum Neurotoxin Type C Cleaves a Single Lys-Ala Bond within the Carboxyl-terminal Region of Syntaxins

    Giampietro Schiavo;Clifford C. Shone;Mark K. Bennett;Richard H. Scheller

  • Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P2

    Gerald R Hammond;Giampietro Schiavo;Robin Francis Irvine

  • A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice

    Dairin Kieran;Majid Hafezparast;Stephanie Bohnert;James R.T. Dick

  • Bacterial protein toxins penetrate cells via a four-step mechanism

    Cesare Montecucco;Emanuele Papini;Giampietro Schiavo

Frequent Co-Authors

Cesare Montecucco
Cesare Montecucco University of Padua
Ornella Rossetto
Ornella Rossetto University of Padua
Elizabeth M. C. Fisher
Elizabeth M. C. Fisher University College London
Emanuele Papini
Emanuele Papini University of Padua
Frederic A. Meunier
Frederic A. Meunier University of Queensland
Fabio Benfenati
Fabio Benfenati Italian Institute of Technology
Eric J. Kremer
Eric J. Kremer University of Montpellier
Kevin Talbot
Kevin Talbot University of Oxford
Thomas H. Söllner
Thomas H. Söllner Heidelberg University
James E. Rothman
James E. Rothman Yale University

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