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Biology and Biochemistry

D-Index
48
Citations
10923
World Ranking
18270
National Ranking
1437

Overview

H. Bobby Gaspar is affiliated with Great Ormond Street Hospital in the United Kingdom, actively contributing to research in the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their work spans molecular biology, genetics, oncology, physiology, and immunology, reflecting a broad engagement with both fundamental and clinical biomedical sciences.

Gaspar's research covers several key topics, primarily in virus-based gene therapy research, CAR-T cell therapy research, and CRISPR and genetic engineering. Additional focal areas include RNA interference and gene delivery, lysosomal storage disorders research, neutrophil, myeloperoxidase and oxidative mechanisms, and cellular mechanics and interactions.

Their recent publications highlight involvement in gene therapy approaches and clinical applications. Selected papers include:

  • Lentiviral gene therapy for X-linked chronic granulomatous disease (2020, Nature Medicine)
  • Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency (2021, New England Journal of Medicine)
  • Long-term safety and efficacy of lentiviral hematopoietic stem/progenitor cell gene therapy for Wiskott-Aldrich syndrome (2022, Nature Medicine)
  • Successful Preclinical Development of Gene Therapy for Recombinase-Activating Gene-1-Deficient SCID (2020, Molecular Therapy - Methods & Clinical Development)
  • Predicting genotoxicity of viral vectors for stem cell gene therapy using gene expression-based machine learning (2021, Molecular Therapy)

Gaspar frequently publishes in venues such as Nature Medicine, Molecular Therapy - Methods & Clinical Development, Molecular Therapy, the Journal of Clinical Immunology, and the New England Journal of Medicine. This reflects a focus on translational research bridging molecular techniques and clinical therapy development.

Among frequent collaborators are Adrian J. Thrasher, Claire Booth, Christine Rivat, Diego León-Rico, and Sara Benedetti, indicating a network of co-authors engaged in related research themes.

Best Publications

  • Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

    Steven J. Howe;Marc R. Mansour;Kerstin Schwarzwaelder;Cynthia Bartholomae

  • International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity

    Capucine Picard;H. Bobby Gaspar;Waleed Al-Herz;Aziz Bousfiha

  • Primary Immunodeficiency Diseases: an Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency 2015

    Capucine Picard;Waleed Al-Herz;Aziz Bousfiha;Jean Laurent Casanova

  • Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

    H Bobby Gaspar;Kathryn L Parsley;Steven Howe;Doug King

  • The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies.

    Aziz Bousfiha;Leïla Jeddane;Capucine Picard;Fatima Ailal

  • A Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency

    Salima Hacein-Bey-Abina;Sung Yun Pai;H. Bobby Gaspar;Myriam Armant

  • Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe: Entering a new century, do we do better?

    Andrew R. Gennery;Andrew R. Gennery;Mary A. Slatter;Mary A. Slatter;Laure Grandin;Pierre Taupin

  • Outcomes Following Gene Therapy in Patients With Severe Wiskott-Aldrich Syndrome

    Salima Hacein-Bey Abina;H. Bobby Gaspar;Johanna Blondeau;Laure Caccavelli

  • Hematopoietic Stem Cell Gene Therapy for Adenosine Deaminase–Deficient Severe Combined Immunodeficiency Leads to Long-Term Immunological Recovery and Metabolic Correction

    H. Bobby Gaspar;H. Bobby Gaspar;Samantha Cooray;Samantha Cooray;Kimberly C. Gilmour;Kimberly C. Gilmour;Kathryn L. Parsley;Kathryn L. Parsley

  • DOCK8 Deficiency: Clinical and Immunological Phenotype and Treatment Options - a Review of 136 Patients

    Susanne E. Aydin;Sara Sebnem Kilic;Caner Aytekin;Ashish Kumar

  • The 2015 IUIS Phenotypic Classification for Primary Immunodeficiencies

    Aziz Bousfiha;Leïla Jeddane;Waleed Al-Herz;Fatima Ailal

  • Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency.

    Qiang Pan-Hammarström;Ulrich Salzer;Likun Du;Jan Fredrik Björkander

  • Improved survival after unrelated donor bone marrow transplantation in children with primary immunodeficiency using a reduced-intensity conditioning regimen

    Kanchan Rao;Persis J. Amrolia;Alison Jones;Catherine M. Cale

  • Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes.

    Ulrich Salzer;Chiara Bacchelli;Sylvie Buckridge;Qiang Pan-Hammarström

  • Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation

    Persis J. Amrolia;Giada Muccioli-Casadei;Helen Huls;Stuart Adams

  • Long-Term Persistence of a Polyclonal T Cell Repertoire After Gene Therapy for X-Linked Severe Combined Immunodeficiency

    H. Bobby Gaspar;Samantha Cooray;Samantha Cooray;Kimberly C. Gilmour;Kimberly C. Gilmour;Kathryn L. Parsley;Kathryn L. Parsley

  • Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo

    Kerstin Schwarzwaelder;Steven J. Howe;Manfred Schmidt;Manfred Schmidt;Martijn H. Brugman

  • Whole-genome sequencing of a sporadic primary immunodeficiency cohort

    Thaventhiran Jed.;H Lango Allen;O S Burren;W Rae

  • Lentiviral gene therapy for X-linked chronic granulomatous disease.

    Donald B. Kohn;Claire Booth;Elizabeth M. Kang;Sung-Yun Pai

  • Comprehensive genomic access to vector integration in clinical gene therapy

    Richard Gabriel;Ralph Eckenberg;Anna Paruzynski;Cynthia C Bartholomae

Frequent Co-Authors

Adrian J. Thrasher
Adrian J. Thrasher University College London
Kimberly Gilmour
Kimberly Gilmour Great Ormond Street Hospital
Donald B. Kohn
Donald B. Kohn University of California, Los Angeles
Paul Veys
Paul Veys Great Ormond Street Hospital
Alain Fischer
Alain Fischer Collège de France
Mimi L.K. Tang
Mimi L.K. Tang Royal Children's Hospital
Axel Schambach
Axel Schambach Hannover Medical School
Marina Cavazzana-Calvo
Marina Cavazzana-Calvo Necker-Enfants Malades Hospital
David A. Williams
David A. Williams Boston Children's Hospital
Capucine Picard
Capucine Picard Université Paris Cité

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