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Hiroaki Mizukami

Hiroaki Mizukami

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
10299
World Ranking
15112
National Ranking
1067

Overview

Hiroaki Mizukami is affiliated with Jichi Medical University in Japan and has a research focus primarily in the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine. Their work spans several subfields including Molecular Biology, Genetics, Epidemiology, Cognitive Neuroscience, and Public Health, Environmental and Occupational Health.

The main topics addressed in their research include:

  • Virus-based gene therapy research
  • Viral Infectious Diseases and Gene Expression in Insects
  • Neural dynamics and brain function
  • CAR-T cell therapy research
  • Mosquito-borne diseases and control
  • Malaria Research and Control
  • Ovarian cancer diagnosis and treatment

Mizukami has published extensively, with recent papers reflecting diverse interests in cellular and neurological studies. Notable recent publications include:

  • "NLRP3 inflammasome-driven IL-1β and IL-18 contribute to lipopolysaccharide-induced septic cardiomyopathy," 2023, Journal of Molecular and Cellular Cardiology
  • "Local and long-distance organization of prefrontal cortex circuits in the marmoset brain," 2023, Neuron
  • "Targeting oxytocin receptor (Oxtr)-expressing neurons in the lateral septum to restore social novelty in autism spectrum disorder mouse models," 2020, Scientific Reports
  • "Direct reprogramming with Sendai virus vectors repaired infarct hearts at the chronic stage," 2021, Biochemical and Biophysical Research Communications
  • "A sensitive and reproducible cell-based assay via secNanoLuc to detect neutralizing antibody against adeno-associated virus vector capsid," 2021, Molecular Therapy - Methods & Clinical Development

Frequent coauthors contributing to their research include Ryota Watano, Kenji Ohba, Akiya Watakabe, Tetsuo Yamamori, and Mitsuhiro Iyori. Mizukami's work often appears in publication venues such as bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Immunology, Human Gene Therapy, Cancer Reports, and Scientific Reports.

Best Publications

  • A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease.

    Shin-ichi Muramatsu;Ken-ichi Fujimoto;Seiya Kato;Hiroaki Mizukami

  • Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis.

    Li-Jun Wang;Yan-Yan Lu;Shin-ichi Muramatsu;Kunihiko Ikeguchi

  • Comparative analyses of adeno-associated viral vector serotypes 1, 2, 5, 8 and 9 in marmoset, mouse and macaque cerebral cortex.

    Akiya Watakabe;Akiya Watakabe;Masanari Ohtsuka;Masaharu Kinoshita;Masafumi Takaji

  • Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain

    Nobuhisa Iwata;Hiroaki Mizukami;Keiro Shirotani;Yoshie Takaki

  • Triple Transduction with Adeno-Associated Virus Vectors Expressing Tyrosine Hydroxylase, Aromatic-L-Amino-Acid Decarboxylase, and GTP Cyclohydrolase I for Gene Therapy of Parkinson's Disease

    Yang Shen;Shin-Ichi Muramatsu;Kunihiko Ikeguchi;Ken-Ichi Fujimoto

  • Fear-enhancing effects of septal oxytocin receptors

    Yomayra F Guzmán;Natalie C Tronson;Natalie C Tronson;Vladimir Jovasevic;Keisuke Sato

  • Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes

    Shin-Ichi Muramatsu;Ken-Ichi Fujimoto;Kunihiko Ikeguchi;Nami Shizuma

  • Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson's disease

    L Wang;S Muramatsu;Y Lu;K Ikeguchi

  • Cell and gene therapy using mesenchymal stem cells (MSCs).

    Keiya Ozawa;Kazuya Sato;Iekuni Oh;Katsutoshi Ozaki

  • Adeno-associated virus 2 co-receptors?

    Jianming Qiu;Hiro Mizukami;Kevin E. Brown

  • Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy.

    Ryosuke Uchibori;Takashi Okada;Takayuki Ito;Masashi Urabe

  • Long-Term Two-Photon Calcium Imaging of Neuronal Populations with Subcellular Resolution in Adult Non-human Primates

    Osamu Sadakane;Yoshito Masamizu;Akiya Watakabe;Akiya Watakabe;Akiya Watakabe;Shin Ichiro Terada

  • Scalable Generation of High-Titer Recombinant Adeno-Associated Virus Type 5 in Insect Cells

    Masashi Urabe;Takayo Nakakura;Ke-Qin Xin;Yoko Obara

  • CRISPR/Cas9-mediated genome editing via postnatal administration of AAV vector cures haemophilia B mice

    Tsukasa Ohmori;Yasumitsu Nagao;Hiroaki Mizukami;Asuka Sakata

  • Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material.

    Martin Lock;Susan McGorray;Alberto Auricchio;Eduard Ayuso

  • Glial dysfunction in the mouse habenula causes depressive-like behaviors and sleep disturbance

    Wanpeng Cui;Hiroaki Mizukami;Michiko Yanagisawa;Tomomi Aida

  • A novel recombinant adeno-associated virus vaccine induces a long-term humoral immune response to human immunodeficiency virus

    Ke-Qin Xin;Masashi Urabe;Jun Yang;Kazuo Nomiyama

  • Specific and efficient transduction of Cochlear inner hair cells with recombinant adeno-associated virus type 3 vector.

    Yuhe Liu;Takashi Okada;Kianoush Sheykholeslami;Kuniko Shimazaki

  • Interleukin-10 Expression Mediated by an Adeno-Associated Virus Vector Prevents Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats

    Takayuki Ito;Takashi Okada;Hiroshi Miyashita;Tatsuya Nomoto

  • Interleukin-10-mediated inhibition of angiogenesis and tumor growth in mice bearing VEGF-producing ovarian cancer.

    Takahiro Kohno;Hiroaki Mizukami;Mitsuaki Suzuki;Yasushi Saga

Frequent Co-Authors

Keiya Ozawa
Keiya Ozawa Jichi Medical University
Shin-ichi Muramatsu
Shin-ichi Muramatsu Jichi Medical University
Uichi Ikeda
Uichi Ikeda Shinshu University
Masafumi Takahashi
Masafumi Takahashi Jichi Medical University
Katsuhiko Nishimori
Katsuhiko Nishimori Tohoku University
Kenji Okuda
Kenji Okuda Yokohama City University
Kazuyuki Shimada
Kazuyuki Shimada Nagoya University
Tadashi Isa
Tadashi Isa Kyoto University
Toshiharu Nagatsu
Toshiharu Nagatsu Fujita Health University

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