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Luigi Bubacco

Luigi Bubacco

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
10738
World Ranking
9416
National Ranking
260

Overview

Luigi Bubacco is affiliated with the University of Padua in Italy and has contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research spans several subfields including neurology, molecular biology, physiology, cell biology, and cellular and molecular neuroscience.

Their main research topics focus on:

  • Parkinson's Disease Mechanisms and Treatments
  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Ubiquitin and proteasome pathways
  • Nuclear Receptors and Signaling
  • Cellular transport and secretion
  • Autophagy in Disease and Therapy

Luigi Bubacco's recent notable papers include:

  • "Copper Ions and Parkinson's Disease: Why Is Homeostasis So Relevant?" (2020) published in Biomolecules
  • "COVID-19 and possible links with Parkinson's disease and parkinsonism: from bench to bedside" (2020) published in npj Parkinson's Disease
  • "Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson's disease" (2022) published in Journal of Neuroinflammation
  • "Parkinson's Disease-Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance" (2021) published in Molecular Neurobiology
  • "α-Synuclein evokes NLRP3 inflammasome-mediated IL-1β secretion from primary human microglia" (2021) published in Glia

Frequent co-authors collaborated with Luigi Bubacco include Elisa Greggio, Michele Sandre, Nicoletta Plotegher, Anna Masato, and Laura Civiero. These collaborators have worked together on numerous publications.

The scientist frequently publishes in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Angewandte Chemie International Edition
  • Angewandte Chemie
  • International Journal of Molecular Sciences
  • Neurobiology of Disease

Best Publications

  • Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies

    Gaia Codolo;Nicoletta Plotegher;Tommaso Pozzobon;Marco Brucale

  • Kinetic and Structural Analysis of the Early Oxidation Products of Dopamine ANALYSIS OF THE INTERACTIONS WITH α-SYNUCLEIN

    Marco Bisaglia;Stefano Mammi;Luigi Bubacco

  • Impaired dopamine metabolism in Parkinson's disease pathogenesis.

    Anna Masato;Nicoletta Plotegher;Daniela Boassa;Luigi Bubacco

  • Conformational Equilibria in Monomeric α-Synuclein at the Single-Molecule Level

    Massimo Sandal;Francesco Valle;Isabella Tessari;Stefano Mammi

  • Structural insights on physiological functions and pathological effects of α-synuclein

    Marco Bisaglia;Stefano Mammi;Luigi Bubacco

  • LRRK2 and neuroinflammation: partners in crime in Parkinson's disease?

    Isabella Russo;Luigi Bubacco;Elisa Greggio

  • GTPase Activity Regulates Kinase Activity and Cellular Phenotypes of Parkinson's Disease-Associated LRRK2

    Alice Biosa;Alzbeta Trancikova;Laura Civiero;Liliane Glauser

  • LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate.

    Elisa Belluzzi;Adriano Gonnelli;Maria-Daniela Cirnaru;Antonella Marte

  • COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside

    David Sulzer;Angelo Antonini;Valentina Leta;Valentina Leta;Anna Nordvig

  • Copper Ions and Parkinson's Disease: Why Is Homeostasis So Relevant?

    Marco Bisaglia;Luigi Bubacco

  • A Topological Model of the Interaction between α-Synuclein and Sodium Dodecyl Sulfate Micelles†

    Marco Bisaglia;Isabella Tessari;Luca Pinato;Massimo Bellanda

  • Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease.

    Elisa Greggio;Elisabetta Bergantino;Donald Carter;Rili Ahmad

  • The Reaction of α-Synuclein with Tyrosinase: POSSIBLE IMPLICATIONS FOR PARKINSON DISEASE*

    Isabella Tessari;Marco Bisaglia;Francesco Valle;Bruno Samorì

  • DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function.

    Nicoletta Plotegher;Giulia Berti;E. Ferrari;E. Ferrari;Isabella Tessari

  • Erratum to: Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells.

    Isabella Russo;Giulia Berti;Nicoletta Plotegher;Nicoletta Plotegher;Greta Bernardo

  • LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex

    Maria D. Cirnaru;Antonella Marte;Elisa Belluzzi;Isabella Russo

  • Structural and Morphological Characterization of Aggregated Species of α-Synuclein Induced by Docosahexaenoic Acid

    Giorgia De Franceschi;Erica Frare;Micaela Pivato;Annalisa Relini

  • Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers.

    Laura Civiero;Renée Vancraenenbroeck;Elisa Belluzzi;Alexandra Beilina

  • Alpha-synuclein pore forming activity upon membrane association.

    Laura Tosatto;Alberto O. Andrighetti;Nicoletta Plotegher;Nicoletta Plotegher;Valeria Antonini

  • Dopamine quinones interact with α-synuclein to form unstructured adducts

    Marco Bisaglia;Laura Tosatto;Francesca Munari;Isabella Tessari

Frequent Co-Authors

Gerard W. Canters
Gerard W. Canters Leiden University
Mark R. Cookson
Mark R. Cookson National Institutes of Health
Jack Peisach
Jack Peisach Albert Einstein College of Medicine
Enrico Monzani
Enrico Monzani University of Pavia
Angelo Antonini
Angelo Antonini University of Padua
Shun Hirota
Shun Hirota Nara Institute of Science and Technology
Ahcène Boumendjel
Ahcène Boumendjel Grenoble Alpes University
Luigi Zecca
Luigi Zecca National Academies of Sciences, Engineering, and Medicine
Stefano Lupi
Stefano Lupi Sapienza University of Rome

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