World's Best Scientists 2026 revealed!

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Medicine

D-Index
82
Citations
34972
World Ranking
15888
National Ranking
495

Overview

Ken Okumura is affiliated with Hirosaki University in Japan and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work spans multiple subfields including molecular biology, oncology, cell biology, plant science, and genetics. The scientist's publications cover a broad range of topics focused on microtubule and mitosis dynamics, chromosomal and genetic variations, ubiquitin and proteasome pathways, genomics and chromatin dynamics, Hedgehog signaling pathway studies, molecular biology techniques and applications, as well as genetic mapping and diversity in plants and animals.

Okumura has published numerous papers in prominent scientific journals. Recent works include:

  • Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties, 2020, Nature Communications
  • Pak1 maintains epidermal stem cells by regulating Langerhans cells and is required for skin carcinogenesis, 2020, Oncogene
  • The Japanese Wild-Derived Inbred Mouse Strain, MSM/Ms in Cancer Research, 2021, Cancers
  • Functional Polymorphism in Pak1-3' Untranslated Region Alters Skin Tumor Susceptibility by Alternative Polyadenylation, 2022, Journal of Investigative Dermatology
  • Meis1 plays roles in cortical development through regulation of cellular proliferative capacity in the embryonic cerebrum, 2022, Biomedical Research

The scientist frequently collaborates with other researchers, with recurring co-authors including Yuichi Wakabayashi, Megumi Saito, Yurika Tokunaga, Eriko Isogai, and Hiroaki Kawanishi. These collaborations have contributed to the breadth of their research output.

Okumura publishes regularly in several scientific venues. Their most frequent publication venues are:

  • Journal of Investigative Dermatology
  • Cancer Science
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Research Square (Research Square)
  • PubMed

Their research primarily focuses on understanding molecular and cellular mechanisms underpinning cancer and other biological processes. Work on topics such as microtubule and mitosis dynamics addresses critical aspects of cell division and genetic regulation. Other areas, including ubiquitin and proteasome pathways, relate to protein degradation processes essential for cellular homeostasis. The research also spans genetic diversity and chromatin dynamics, signaling pathways like Hedgehog, and experimental molecular biology techniques.

Best Publications

  • 2017 HRS / EHRA / ECAS / APHRS / SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

    Hugh Calkins;Gerhard Hindricks;Riccardo Cappato;Young Hoon Kim

  • Localization and mechanism of secretion of B-type natriuretic peptide in comparison with those of A-type natriuretic peptide in normal subjects and patients with heart failure.

    Hirofumi Yasue;Michihiro Yoshimura;Hitoshi Sumida;Koichi Kikuta

  • Different secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure.

    Michihiro Yoshimura;Hirofumi Yasue;Ken Okumura;Hisao Ogawa

  • 2015 HRS/EHRA/APHRS/SOLAECE expert consensus statement on optimal implantable cardioverter-defibrillator programming and testing

    Bruce L. Wilkoff;Laurent Fauchier;Martin K. Stiles;Carlos A. Morillo

  • 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary

    Hugh Calkins;Gerhard Hindricks;Riccardo Cappato;Young Hoon Kim

  • Long-term prognosis for patients with variant angina and influential factors.

    H Yasue;A Takizawa;M Nagao;S Nishida

  • JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure ― Digest Version ―

    Hiroyuki Tsutsui;Mitsuaki Isobe;Hiroshi Ito;Ken Okumura

  • Nitric Oxide Activity Is Deficient in Spasm Arteries of Patients With Coronary Spastic Angina

    Kiyotaka Kugiyama;Hirofumi Yasue;Ken Okumura;Hisao Ogawa

  • Prevalence of atrial fibrillation in the general population of Japan: an analysis based on periodic health examination.

    Hiroshi Inoue;Akira Fujiki;Hideki Origasa;Satoshi Ogawa

  • Responses of angiographically normal human coronary arteries to intracoronary injection of acetylcholine by age and segment. Possible role of early coronary atherosclerosis.

    H Yasue;K Matsuyama;K Okumura;Y Morikami

  • Clinical application of atrial natriuretic polypeptide in patients with congestive heart failure: beneficial effects on left ventricular function.

    Y Saito;K Nakao;K Nishimura;A Sugawara

  • Uninterrupted Dabigatran versus Warfarin for Ablation in Atrial Fibrillation

    Hugh Calkins;Stephan Willems;Edward P. Gerstenfeld;Atul Verma

  • Plasma levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 are increased in the coronary circulation in patients with acute coronary syndrome

    Yoichi Inokubo;Hiroyuki Hanada;Hiroshi Ishizaka;Tomohisa Fukushi

  • Sensitivity and specificity of intracoronary injection of acetylcholine for the induction of coronary artery spasm.

    Ken Okumura;Hirofumi Yasue;Koshi Matsuyama;Kazuo Goto

  • Long-term prognosis of probands with Brugada-pattern ST-elevation in leads V1-V3.

    Shiro Kamakura;Tohru Ohe;Kiyoshi Nakazawa;Yoshifusa Aizawa

  • Study on the Relationship Between Plasma Nitrite and Nitrate Level and Salt Sensitivity in Human Hypertension: Modulation of Nitric Oxide Synthesis by Salt Intake

    Naoto Fujiwara;Tomohiro Osanai;Takaatsu Kamada;Takeshi Katoh

  • 2021 Focused Update Consensus Guidelines of the Asia Pacific Heart Rhythm Society on Stroke Prevention in Atrial Fibrillation: Executive Summary.

    Tze-Fan Chao;Boyoung Joung;Yoshihide Takahashi;Toon Wei Lim

  • Demonstration of an area of slow conduction in atrial flutter

    Brian Olshansky;Ken Okumura;Ken Okumura;Paul G. Hess;Paul G. Hess;Albert L. Waldo;Albert L. Waldo

  • Multivessel coronary spasm in patients with variant angina: a study with intracoronary injection of acetylcholine.

    K Okumura;H Yasue;Y Horio;K Takaoka

  • A Combined Optical Coherence Tomography and Intravascular Ultrasound Study on Plaque Rupture, Plaque Erosion, and Calcified Nodule in Patients With ST-Segment Elevation Myocardial Infarction: Incidence, Morphologic Characteristics, and Outcomes After Percutaneous Coronary Intervention.

    Takumi Higuma;Tsunenari Soeda;Naoki Abe;Masahiro Yamada

Frequent Co-Authors

Hirofumi Yasue
Hirofumi Yasue Kumamoto University
Hisao Ogawa
Hisao Ogawa Kumamoto University
Yoshifusa Aizawa
Yoshifusa Aizawa Tachikawa Medical Center
Wataru Shimizu
Wataru Shimizu Nippon Medical School
Michihiro Yoshimura
Michihiro Yoshimura Jikei University School of Medicine
Hiroyuki Tsutsui
Hiroyuki Tsutsui Kyushu University
Kei Satoh
Kei Satoh Hirosaki University
Kazuwa Nakao
Kazuwa Nakao Kyoto University
Tadaatsu Imaizumi
Tadaatsu Imaizumi Hirosaki University
Ik-Kyung Jang
Ik-Kyung Jang Massachusetts General Hospital

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