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Overview

Lesley McGuffog is affiliated with the University of Cambridge in the United Kingdom. Their research primarily focuses on genetics, molecular biology, and the study of BRCA gene mutations in cancer. The scope of their work encompasses related areas such as nutrition, genetics, disease, and genomic variations with a particular emphasis on cancer risk and pathology.

McGuffog's research contributions are evident in a range of publications across several recognized venues. They have published extensively in the following journals and platforms:

  • UNC Libraries
  • Nature Communications
  • Genetics in Medicine
  • JNCI Journal of the National Cancer Institute
  • British Journal of Cancer

Frequent collaboration is a notable characteristic of their work. Regular co-authors include:

  • Irene L. Andrulis (10 joint publications)
  • Daniel Barrowdale (10 joint publications)
  • Maria A. Caligo (10 joint publications)
  • Olga M. Sinilnikova (9 joint publications)
  • Kathleen Claes (8 joint publications)

Lesley McGuffog's main fields of study involve biochemistry, genetics, and molecular biology, with a strong focus on genetics. Other subfields include reproductive medicine, public health, environmental and occupational health, and oncology.

The central topics covered in their body of work include:

  • BRCA gene mutations in cancer
  • Nutrition, genetics, and disease
  • Genomic variations and chromosomal abnormalities
  • Ovarian cancer diagnosis and treatment
  • Male breast health studies
  • PARP inhibition in cancer therapy
  • Genetic factors in colorectal cancer

Notable recent publications by Lesley McGuffog include:

  • Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants (2020, Genetics in Medicine)
  • Breast and Prostate Cancer Risks for Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores (2021, JNCI Journal of the National Cancer Institute)
  • A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers (2021, Nature Communications)
  • Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction (2020, UNC Libraries)
  • Ovarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2 (2023, British Journal of Cancer)

Best Publications

  • Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers

    Karoline B. Kuchenbaecker;Karoline B. Kuchenbaecker;John L. Hopper;Daniel R. Barnes;Kelly-Anne Phillips

  • Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

    Hanne Meijers-Heijboer;Ans van den Ouweland;Jan Klijn;Marijke Wasielewski

  • The Pathology of Familial Breast Cancer: Predictive Value of Immunohistochemical Markers Estrogen Receptor, Progesterone Receptor, HER-2, and p53 in Patients With Mutations in BRCA1 and BRCA2

    Sunil R. Lakhani;Marc J. van de Vijver;Jocelyne Jacquemier;Thomas J. Anderson

  • PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

    Nazneen Rahman;Sheila Seal;Deborah Thompson;Patrick Kelly

  • ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles

    Anthony Renwick;Deborah Thompson;Sheila Seal;Patrick Kelly

  • Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles

    Sheila Seal;Deborah Thompson;Anthony Renwick;Anna Elliott

  • Prediction of BRCA1 Status in Patients with Breast Cancer Using Estrogen Receptor and Basal Phenotype

    Sunil R. Lakhani;Jorge S. Reis-Filho;Laura Fulford;Frederique Penault-Llorca

  • Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

    Nasim Mavaddat;Daniel Barrowdale;Irene L. Andrulis;Susan M. Domchek

  • Association Between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Cancer

    Kelly L. Bolton;Kelly L. Bolton;Georgia Chenevix-Trench;Cindy Goh;Siegal Sadetzki

  • Cancer Risks and Mortality in Heterozygous ATM Mutation Carriers

    Deborah Thompson;Silvia Duedal;Jennifer Kirner;Lesley McGuffog

  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

    Stig E. Bojesen;Stig E. Bojesen;Karen A. Pooley;Sharon E. Johnatty;Jonathan Beesley

  • Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.

    Timothy R. Rebbeck;Nandita Mitra;Fei Wan;Olga M. Sinilnikova

  • Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

    Catherine M Phelan;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Jonathan P Tyrer;Siddhartha P Kar

  • A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population

    Antonis C. Antoniou;Xianshu Wang;Zachary S. Fredericksen;Lesley McGuffog

  • Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.

    Roger L Milne;Roger L Milne;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Kyriaki Michailidou;Kyriaki Michailidou;Jonathan Beesley

  • Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

    Haoyu Zhang;Haoyu Zhang;Thomas U. Ahearn;Julie Lecarpentier;Daniel Barnes

  • Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk

    Fergus J. Couch;Xianshu Wang;Lesley McGuffog;Andrew Lee

  • The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers.

    Christopher I. Amos;Joe Dennis;Zhaoming Wang;Jinyoung Byun

  • Pathology of ovarian cancers in BRCA1 and BRCA2 carriers.

    Sunil R. Lakhani;Sanjiv Manek;Frederique Penault-Llorca;Adrienne Flanagan

  • Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.

    Mitra N Rebbeck Tr;F Wan;Maurizio Genuardi

Frequent Co-Authors

Irene L. Andrulis
Irene L. Andrulis University of Toronto
Georgia Chenevix-Trench
Georgia Chenevix-Trench QIMR Berghofer Medical Research Institute
Fergus J. Couch
Fergus J. Couch Mayo Clinic
Katherine L. Nathanson
Katherine L. Nathanson University of Pennsylvania
Heli Nevanlinna
Heli Nevanlinna University of Helsinki
Melissa C. Southey
Melissa C. Southey Monash University
Susan M. Domchek
Susan M. Domchek University of Pennsylvania
Javier Benitez
Javier Benitez Instituto de Salud Carlos III
Anna Jakubowska
Anna Jakubowska Pomeranian Medical University

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