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Best Female Scientists
2025

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Best Female Scientists

D-Index
112
Citations
56262
World Ranking
802
National Ranking
487

Medicine

D-Index
118
Citations
62944
World Ranking
4001
National Ranking
2188

Research.com Recognitions

  • 2025 - Research.com Best Female Scientists Award
  • 2018 - Member of the National Academy of Medicine (NAM)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Susan M. Domchek is affiliated with the University of Pennsylvania in the United States. Their research primarily focuses on genetics, oncology, and molecular biology, with specific attention to cancer genomics and diagnostic methods. The scientist's work encompasses broad topics related to cancer biology, particularly the role of BRCA gene mutations and mechanisms of DNA repair.

The main fields of study associated with Susan M. Domchek include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Key subfields reflected in their publications are:

  • Genetics
  • Oncology
  • Molecular Biology
  • Cancer Research
  • Pulmonary and Respiratory Medicine

The principal research topics address:

  • BRCA gene mutations in cancer
  • PARP inhibition in cancer therapy
  • Cancer Genomics and Diagnostics
  • DNA Repair Mechanisms
  • Nutrition, Genetics, and Disease
  • Genomics and Rare Diseases
  • Genetic factors in colorectal cancer

Susan M. Domchek has coauthored extensively with several researchers, including:

  • Katherine L. Nathanson
  • Fergus J. Couch
  • Judy E. Garber
  • Mark E. Robson
  • Jeffrey N. Weitzel

Their frequent publication venues include:

  • Journal of Clinical Oncology
  • Cancer Research
  • UNC Libraries
  • Genetics in Medicine
  • Gynecologic Oncology

Notable recent papers authored or coauthored by Susan M. Domchek cover topics related to breast cancer genetics, familial risk assessments, and genome-wide association studies. Some of these include:

  • Adjuvant Olaparib for Patients with BRCA1 - or BRCA2 -Mutated Breast Cancer, 2021, New England Journal of Medicine
  • Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology, 2021, Journal of the National Comprehensive Cancer Network
  • A Population-Based Study of Genes Previously Implicated in Breast Cancer, 2021, New England Journal of Medicine
  • Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses, 2020, Nature Genetics
  • NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 1.2020, 2020, Journal of the National Comprehensive Cancer Network

Awards attributed to Susan M. Domchek include membership in prestigious organizations such as the National Academy of Medicine (NAM) in 2018 and the Association of American Physicians.

Best Publications

  • Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation

    Mark Robson;Seock Ah Im;Elżbieta Senkus;Binghe Xu

  • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

    Andrew Tutt;Mark Robson;Judy E Garber;Susan M Domchek

  • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer

    A Tutt;M Robson;J E Garber;S M Domchek

  • Olaparib Monotherapy in Patients With Advanced Cancer and a Germline BRCA1/2 Mutation

    Bella Kaufman;Ronnie Shapira-Frommer;Rita K. Schmutzler;M. William Audeh

  • Association of Risk-Reducing Surgery in BRCA1 or BRCA2 Mutation Carriers With Cancer Risk and Mortality

    Susan M. Domchek;Tara M. Friebel;Christian F. Singer;D. Gareth Evans

  • Meta-analysis of Risk Reduction Estimates Associated With Risk-Reducing Salpingo-oophorectomy in BRCA1 or BRCA2 Mutation Carriers

    Timothy R. Rebbeck;Noah D. Kauff;Susan M. Domchek

  • Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer

    Andrew N.J. Tutt;Judy E. Garber;Bella Kaufman;Giuseppe Viale

  • Breast-Cancer Risk in Families with Mutations in PALB2

    A. C. Antoniou;S. Casadei;T. Heikkinen;D. Barrowdale

  • Central nervous system metastases in women who receive trastuzumab‐based therapy for metastatic breast carcinoma

    Johanna C. Bendell;Susan M. Domchek;Harold J. Burstein M.D.;Lyndsay Harris

  • Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk

    Douglas Frederick Easton;Paul David Pharoah;Antonis C. Antoniou;Marc Derek Tischkowitz

  • Genetic/familial high-risk assessment: Breast, ovarian, and pancreatic, version 2.2021

    Mary B. Daly;Tuya Pal;Michael P. Berry;Saundra S. Buys

  • American Society of Clinical Oncology Policy Statement Update: Genetic and Genomic Testing for Cancer Susceptibility

    Mark E. Robson;Mark E. Robson;Angela R. Bradbury;Banu K Arun;Susan M. Domchek

  • Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

    Nasim Mavaddat;Daniel Barrowdale;Irene L. Andrulis;Susan M. Domchek

  • Risk-Reducing Salpingo-Oophorectomy for the Prevention of BRCA1- and BRCA2-Associated Breast and Gynecologic Cancer: A Multicenter, Prospective Study

    Noah D. Kauff;Susan M. Domchek;Tara M. Friebel;Mark E. Robson

  • OlympiAD final overall survival and tolerability results: Olaparib versus chemotherapy treatment of physician’s choice in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer

    M.E. Robson;N. Tung;P. Conte;S.-A. Im

  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

    Stig E. Bojesen;Stig E. Bojesen;Karen A. Pooley;Sharon E. Johnatty;Jonathan Beesley

  • A Population-Based Study of Genes Previously Implicated in Breast Cancer

    Chunling Hu;Steven N Hart;Rohan Gnanaolivu;Hongyan Huang

  • Effect of Short-Term Hormone Replacement Therapy on Breast Cancer Risk Reduction After Bilateral Prophylactic Oophorectomy in BRCA1 and BRCA2 Mutation Carriers: The PROSE Study Group

    Timothy R. Rebbeck;Tara Friebel;Theresa Wagner;Henry T. Lynch

  • Multidisciplinary Meeting on Male Breast Cancer: Summary and Research Recommendations

    Larissa A. Korde;Jo Anne Zujewski;Leah Kamin;Sharon Hermes Giordano

  • Breast Cancer Risk Among Male BRCA1 and BRCA2 Mutation Carriers

    Yu Chuan Tai;Susan Domchek;Giovanni Parmigiani;Sining Chen

Frequent Co-Authors

Katherine L. Nathanson
Katherine L. Nathanson University of Pennsylvania
Fergus J. Couch
Fergus J. Couch Mayo Clinic
Judy Garber
Judy Garber Harvard University
Mark E. Robson
Mark E. Robson Memorial Sloan Kettering Cancer Center
Kenneth Offit
Kenneth Offit Memorial Sloan Kettering Cancer Center
Susan L. Neuhausen
Susan L. Neuhausen City Of Hope National Medical Center
Irene L. Andrulis
Irene L. Andrulis University of Toronto
Jeffrey N. Weitzel
Jeffrey N. Weitzel Natera (United States)
Timothy R. Rebbeck
Timothy R. Rebbeck Harvard University

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