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Shyamala Maheswaran

Shyamala Maheswaran

D-Index & Metrics

Medicine

D-Index
86
Citations
43451
World Ranking
13867
National Ranking
7038

Overview

Shyamala Maheswaran is affiliated with Harvard University in the United States. Their research primarily focuses on fields within Medicine and Biochemistry, Genetics, and Molecular Biology, with a detailed emphasis on Oncology, Cancer Research, Molecular Biology, Pulmonary and Respiratory Medicine, and Biomedical Engineering.

Their scientific work spans multiple main topics, which include:

  • Cancer Cells and Metastasis
  • Cancer Genomics and Diagnostics
  • Advanced Breast Cancer Therapies
  • Microfluidic and Bio-sensing Technologies
  • RNA modifications and cancer
  • RNA Interference and Gene Delivery
  • Prostate Cancer Treatment and Research

Maheswaran's recent published papers include:

  • Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis, 2020, Science
  • The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis, 2020, Cancer Discovery
  • Ultrahigh-throughput magnetic sorting of large blood volumes for epitope-agnostic isolation of circulating tumor cells, 2020, Proceedings of the National Academy of Sciences
  • HIF1A signaling selectively supports proliferation of breast cancer in the brain, 2020, Nature Communications
  • Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target, 2020, Nature Communications

The scientist frequently collaborates with colleagues including:

  • Daniel A. Haber
  • Mehmet Toner
  • Taronish D. Dubash
  • Ben S. Wittner
  • Aditya Bardia

Their publications appear mostly in the following venues:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Clinical Cancer Research
  • Proceedings of the National Academy of Sciences
  • Nature Communications

Best Publications

  • Isolation of rare circulating tumour cells in cancer patients by microchip technology.

    Sunitha Nagrath;Lecia V. Sequist;Shyamala Maheswaran;Daphne W. Bell;Daphne W. Bell

  • A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

    Sreenath V. Sharma;Diana Y. Lee;Bihua Li;Margaret P. Quinlan

  • Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

    Min Yu;Aditya Bardia;Ben S. Wittner;Shannon L. Stott

  • Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

    Nicola Aceto;Aditya Bardia;David T. Miyamoto;Maria C. Donaldson

  • Detection of Mutations in EGFR in Circulating Lung-Cancer Cells

    Shyamala Maheswaran;Lecia V. Sequist;Sunitha Nagrath;Lindsey Ulkus

  • Isolation of circulating tumor cells using a microvortex-generating herringbone-chip

    Shannon L. Stott;Chia Hsien Hsu;Chia Hsien Hsu;Chia Hsien Hsu;Dina I. Tsukrov;Min Yu

  • Circulating tumor cells: approaches to isolation and characterization

    Min Yu;Shannon Stott;Mehmet Toner;Shyamala Maheswaran

  • Inertial Focusing for Tumor Antigen–Dependent and –Independent Sorting of Rare Circulating Tumor Cells

    Emre Ozkumur;Ajay M. Shah;Jordan C. Ciciliano;Benjamin L. Emmink

  • Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility

    Min Yu;Min Yu;Aditya Bardia;Nicola Aceto;Francesca Bersani

  • Microfluidic, marker-free isolation of circulating tumor cells from blood samples

    Nezihi Murat Karabacak;Philipp S Spuhler;Fabio Fachin;Eugene J Lim

  • A microfluidic device for label-free, physical capture of circulating tumor cell clusters

    A Fatih Sarioglu;Nicola Aceto;Nikola Kojic;Maria C Donaldson

  • RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance

    David T. Miyamoto;Yu Zheng;Ben S. Wittner;Richard J. Lee

  • Isolation and Characterization of Circulating Tumor Cells from Patients with Localized and Metastatic Prostate Cancer

    Shannon L. Stott;Richard J. Lee;Sunitha Nagrath;Min Yu

  • Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers.

    David T. Ting;Doron Lipson;Suchismita Paul;Brian W. Brannigan

  • RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis

    Min Yu;David Tsai Ting;Shannon Stott;Ben Wittner

  • Single-Cell RNA Sequencing Identifies Extracellular Matrix Gene Expression by Pancreatic Circulating Tumor Cells

    David T. Ting;Ben S. Wittner;Matteo Ligorio;Matteo Ligorio;Nicole Vincent Jordan

  • Genomic Alterations of Anaplastic Lymphoma Kinase May Sensitize Tumors to Anaplastic Lymphoma Kinase Inhibitors

    Ultan McDermott;A. John Iafrate;Nathanael S. Gray;Toshi Shioda

  • Clusters of circulating tumor cells traverse capillary-sized vessels

    Sam H. Au;Brian D. Storey;John C. Moore;Qin Tang

  • A conduit to metastasis: circulating tumor cell biology.

    Douglas S. Micalizzi;Shyamala Maheswaran;Daniel A. Haber;Daniel A. Haber

  • Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer

    Matteo Ligorio;Srinjoy Sil;Jose Malagon-Lopez;Linda T. Nieman

Frequent Co-Authors

Daniel A. Haber
Daniel A. Haber Harvard University
Mehmet Toner
Mehmet Toner Harvard University
David T. Ting
David T. Ting Harvard University
Lecia V. Sequist
Lecia V. Sequist Harvard University
Sridhar Ramaswamy
Sridhar Ramaswamy Harvard University
Aditya Bardia
Aditya Bardia Harvard University
Michael S. Lawrence
Michael S. Lawrence Harvard University
Patricia K. Donahoe
Patricia K. Donahoe Harvard University
Richard T. Lee
Richard T. Lee Harvard University
Wilhelm Haas
Wilhelm Haas Harvard University

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