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Neuroscience

D-Index
70
Citations
26514
World Ranking
2462
National Ranking
1163

Medicine

D-Index
70
Citations
26593
World Ranking
20054
National Ranking
9985

Overview

Luigi Zecca is affiliated with the National Academies of Sciences, Engineering, and Medicine in the United States. Their research primarily focuses on the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience, with notable work in subfields such as Neurology, Cell Biology, Cellular and Molecular Neuroscience, Molecular Biology, and Physiology.

Zecca's main research topics include Parkinson's Disease mechanisms and treatments, melanin and skin pigmentation, neuroinflammation and neurodegeneration mechanisms, neurological diseases and metabolism, neurological disorders and treatments, Alzheimer's disease research and treatments, and nuclear receptors and signaling.

The scientist has published extensively in several venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • npj Parkinson's Disease
  • Angewandte Chemie International Edition
  • Angewandte Chemie
  • Progress in Neurobiology

Frequent collaborators of Luigi Zecca include:

  • Fabio A. Zucca
  • Luigi Casella
  • Andrea Capucciati
  • Enrico Monzani
  • Michela Sturini

Selected recent publications highlight their contributions in neurobiology and Parkinson's disease research:

  • COVID-19 and possible links with Parkinson's disease and parkinsonism: from bench to bedside, 2020, npj Parkinson's Disease
  • Interactions of dopamine, iron, and alpha-synuclein linked to dopaminergic neuron vulnerability in Parkinson's disease and Neurodegeneration with Brain Iron Accumulation disorders, 2022, Neurobiology of Disease
  • The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects, 2020, Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • Oleh Hornykiewicz, a giant in the understanding and treatment of Parkinson disease, 2021, npj Parkinson's Disease
  • Neuromelanins in brain aging and Parkinson's disease: synthesis, structure, neuroinflammatory, and neurodegenerative role, 2022, IUBMB Life

Best Publications

  • Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

    Michelle L. Block;Luigi Zecca;Jau Shyong Hong

  • Iron, brain ageing and neurodegenerative disorders

    Luigi Zecca;Moussa B. H. Youdim;Peter Riederer;James R. Connor

  • The role of iron in brain ageing and neurodegenerative disorders

    Roberta J Ward;Roberta J Ward;Fabio A Zucca;Jeff H Duyn;Robert R Crichton

  • Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis.

    Annalisa Frattini;Paul J. Orchard;Cristina Sobacchi;Silvia Giliani

  • Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease.

    Fabio A. Zucca;Juan Segura-Aguilar;Emanuele Ferrari;Patricia Muñoz

  • The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging

    Luigi Zecca;Antonella Stroppolo;Alberto Gatti;Davide Tampellini

  • Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles.

    David Sulzer;Johanna Bogulavsky;Kristin E. Larsen;Gerald Behr

  • Protective and toxic roles of dopamine in Parkinson's disease

    Juan Segura-Aguilar;Irmgard Paris;Irmgard Paris;Patricia Muñoz;Emanuele Ferrari

  • Melanins and melanogenesis: from pigment cells to human health and technological applications.

    Marco d'Ischia;Kazumasa Wakamatsu;Fabio Cicoira;Eduardo Di Mauro

  • Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes.

    Luigi Zecca;Mario Gallorini;Volker Schünemann;Alfred X. Trautwein

  • Aluminium in Alzheimer's disease: are we still at a crossroad?

    Veer Bala Gupta;S. Anitha;M. L. Hegde;L. Zecca

  • Activation of microglia by human neuromelanin is NF-κB dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson’s disease

    Henrik Wilms;Philip Rosenstiel;Jobst Sievers;Günther Deuschl

  • Intraneuronal dopamine-quinone synthesis: a review.

    David Sulzer;Luigi Zecca

  • Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism

    Michela Barichella;Marco Severgnini;Roberto Cilia;Erica Cassani

  • MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

    Carolina Cebrian;Fabio A Zucca;Pierluigi Mauri;Julius A. Steinbeck

  • Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

    Matthew J Betts;Matthew J Betts;Evgeniya Kirilina;Evgeniya Kirilina;Maria C G Otaduy;Dimo Ivanov

  • Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics

    Luigi Zecca;Fabio A Zucca;Henrik Wilms;David Sulzer

  • Neuromelanin Activates Microglia and Induces Degeneration of Dopaminergic Neurons: Implications for Progression of Parkinson’s Disease

    Wei Zhang;Kester Phillips;Albert R. Wielgus;Jie Liu

  • The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson’s disease

    Luigi Zecca;Ruggero Fariello;Peter Riederer;David Sulzer

  • Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour.

    L Zecca;D Tampellini;M Gerlach;P Riederer

  • In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage.

    Luigi Zecca;Daniela Berg;Thomas Arzberger;Petra Ruprecht

  • Inflammation in Parkinson's diseases and other neurodegenerative diseases: cause and therapeutic implications.

    H Wilms;L Zecca;P Rosenstiel;J Sievers

Frequent Co-Authors

David Sulzer
David Sulzer Columbia University
Peter Riederer
Peter Riederer University of Würzburg
Shosuke Ito
Shosuke Ito Fujita Health University
Kazumasa Wakamatsu
Kazumasa Wakamatsu Fujita Health University
Enrico Monzani
Enrico Monzani University of Pavia
Paolo Vezzoni
Paolo Vezzoni National Research Council (CNR)
Sandro Sonnino
Sandro Sonnino University of Milan
Kay L. Double
Kay L. Double University of Sydney
John D. Simon
John D. Simon Duke University
Moussa B.H. Youdim
Moussa B.H. Youdim Technion – Israel Institute of Technology

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