Andrew B. West

Overview

Best Publications

• MOLECULAR PATHOPHYSIOLOGY OF PARKINSON'S DISEASE

  Darren J. Moore;Andrew B. West;Valina L. Dawson;Ted M. Dawson

  1588
  Citations

• Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

  Andrew B. West;Darren J. Moore;Saskia Biskup;Artem Bugayenko

  1435
  Citations

• A genome-wide linkage and association scan reveals novel loci for autism

  Lauren A. Weiss;Lauren A. Weiss;Dan E. Arking;Mark J. Daly;Mark J. Daly;Aravinda Chakravarti

  766
  Citations

• Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

  Andrew B. West;Darren J. Moore;Catherine Choi;Shaida A. Andrabi

  673
  Citations

• Localization of LRRK2 to membranous and vesicular structures in mammalian brain.

  Saskia Biskup;Darren J. Moore;Fulvio Celsi;Shinji Higashi;Shinji Higashi

  642
  Citations

• Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

  Wanli W. Smith;Zhong Pei;Haibing Jiang;Darren J. Moore

  556
  Citations

• Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism.

  Simone Gupta;Shannon E. Ellis;Foram N. Ashar;Anna Moes

  527
  Citations

• LRRK2 inhibition attenuates microglial inflammatory responses.

  Mark S. Moehle;Philip J. Webber;Tonia Tse;Nour Sukar

  479
  Citations

• Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

  Byoung Dae Lee;Joo Ho Shin;Jackalina Vankampen;Leonard Petrucelli

  423
  Citations

• α-synuclein gene haplotypes are associated with Parkinson’s disease

  Matt Farrer;Demetrius M. Maraganore;Paul Lockhart;Andrew Singleton

  422
  Citations

• Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape

  Kenneth Day;Lindsay L Waite;Anna Thalacker-Mercer;Andrew West

  362
  Citations

• Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response

  Carol W. Gray;Robin V. Ward;Eric Karran;Sandra Turconi

  356
  Citations

• Parkinson disease and the immune system - associations, mechanisms and therapeutics.

  Eng-King Tan;Eng-King Tan;Yin-Xia Chao;Yin-Xia Chao;Andrew West;Ling-Ling Chan;Ling-Ling Chan

  340
  Citations

• Complex relationship between Parkin mutations and Parkinson disease.

  Andrew West;Magali Periquet;Sarah Lincoln;Christoph B. Lücking;Christoph B. Lücking

  264
  Citations

• LRRK2 levels in immune cells are increased in Parkinson’s disease

  D.A Cook;G.T Kannarkat;A.F Cintron;Laura M. Butkovich

  262
  Citations

• Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.

  Laura A. Volpicelli-Daley;Karen L. Gamble;Christine E. Schultheiss;Dawn M. Riddle

  258
  Citations

• LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.

  Zhiyong Liu;Nicole Bryant;Ravindran Kumaran;Alexandra Beilina

  245
  Citations

• Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death.

  Shaida A. Andrabi;Ho Chul Kang;Jean François Haince;Yun Il Lee

  235
  Citations

• Abrogation of α-synuclein–mediated dopaminergic neurodegeneration in LRRK2-deficient rats

  João P. L. Daher;Laura A. Volpicelli-Daley;Jonathan P. Blackburn;Mark S. Moehle

  221
  Citations

• Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization.

  Saurabh Sen;Philip J. Webber;Andrew B. West

  221
  Citations