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Biology and Biochemistry

D-Index
62
Citations
18353
World Ranking
10598
National Ranking
188

Overview

Darren J. Moore is affiliated with the École Polytechnique Fédérale de Lausanne in Switzerland. Their research focuses primarily on medical and biochemical aspects related to neurological conditions, especially Parkinson's disease and related neurodegenerative disorders.

The scientist has contributed extensively to the study of Parkinson's disease mechanisms and treatments, along with research on lysosomal storage disorders and cellular transport processes. Other areas of investigation include neurological disorders and treatments, Alzheimer's disease research, neurological diseases in relation to metabolism, and nuclear receptor signaling pathways.

Moore's work spans various fields of study:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

Within these fields, they have a strong focus on several subfields related to the nervous system and cellular function:

  • Neurology
  • Physiology
  • Cell Biology
  • Cellular and Molecular Neuroscience
  • Molecular Biology

Recent publications authored or co-authored by Moore reflect their focus on Parkinson's disease and neurodegeneration, covering aspects such as protein interactions, neurodegeneration mechanisms, and contributions of cellular transport systems. Notable recent papers include:

  • "LRRK2 and the Endolysosomal System in Parkinson's Disease" (2020), Journal of Parkinson's Disease
  • "The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network" (2020), Cell Reports
  • "Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity" (2020), Proceedings of the National Academy of Sciences
  • "Understanding the contributions of VPS35 and the retromer in neurodegenerative disease" (2022), Neurobiology of Disease
  • "Defining the Riddle in Order to Solve It: There Is More Than One 'Parkinson's Disease'" (2023), Movement Disorders

The scientist frequently publishes in several specialized venues that focus on neurobiology and Parkinson's disease research. The top publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neurobiology of Disease
  • Journal of Parkinson's Disease
  • npj Parkinson's Disease
  • Molecular Neurodegeneration

Moore has collaborated regularly with several co-authors in the field. Frequent collaborators include:

  • Dylan J. Dues
  • An Phu Tran Nguyen
  • Madalynn Erb
  • Nathan Levine
  • Xi Chen

Best Publications

  • PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

    Cristofol Vives-Bauza;Chun Zhou;Yong Huang;Mei Cui

  • MOLECULAR PATHOPHYSIOLOGY OF PARKINSON'S DISEASE

    Darren J. Moore;Andrew B. West;Valina L. Dawson;Ted M. Dawson

  • Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

    Andrew B. West;Darren J. Moore;Saskia Biskup;Artem Bugayenko

  • AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1

    Alison I. Muir;Larissa Chamberlain;Nabil A. Elshourbagy;David Michalovich

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

    Andrew B. West;Darren J. Moore;Catherine Choi;Shaida A. Andrabi

  • α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.

    Bruno Fauvet;Martial Kamdem Mbefo;Mohamed-Bilal Fares;Carole Desobry

  • Localization of LRRK2 to membranous and vesicular structures in mammalian brain.

    Saskia Biskup;Darren J. Moore;Fulvio Celsi;Shinji Higashi;Shinji Higashi

  • Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

    Wanli W. Smith;Zhong Pei;Haibing Jiang;Darren J. Moore

  • Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

    Li Zhang;Mika Shimoji;Bobby Thomas;Darren J. Moore

  • Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

    David Ramonet;João Paulo L. Daher;João Paulo L. Daher;Brian M. Lin;Klodjan Stafa

  • Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

    Darren J. Moore;Li Zhang;Juan Troncoso;Michael K. Lee

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.

    Darren J. Moore;Li Zhang;Ted M. Dawson;Valina L. Dawson

  • Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1

    Liliane Glauser;Sarah Sonnay;Klodjan Stafa;Darren J. Moore

  • The Chaperone Activity of Heat Shock Protein 90 Is Critical for Maintaining the Stability of Leucine-Rich Repeat Kinase 2

    Lizhen Wang;Chengsong Xie;Elisa Greggio;Loukia Parisiadou

  • GTPase activity plays a key role in the pathobiology of LRRK2

    Yulan Xiong;Candice E. Coombes;Austin Kilaru;Xiaojie Li

  • CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

    Han Seok Ko;Rachel Bailey;Wanli W. Smith;Zhaohui Liu

  • Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain.

    Shinji Higashi;Saskia Biskup;Andrew B. West;Daniel Trinkaus

  • Dynamic and redundant regulation of LRRK2 and LRRK1 expression

    Saskia Biskup;Darren J Moore;Alexis Rea;Bettina Lorenz-Deperieux

Frequent Co-Authors

Ted M. Dawson
Ted M. Dawson Johns Hopkins University School of Medicine
Valina L. Dawson
Valina L. Dawson Johns Hopkins University School of Medicine
Andrew B. West
Andrew B. West Duke University
Piers C. Emson
Piers C. Emson Babraham Institute
Bernard L. Schneider
Bernard L. Schneider École Polytechnique Fédérale de Lausanne
Juan C. Troncoso
Juan C. Troncoso Johns Hopkins University School of Medicine
Richard L.M. Faull
Richard L.M. Faull University of Auckland
Patrick Aebischer
Patrick Aebischer École Polytechnique Fédérale de Lausanne
Neal G. Copeland
Neal G. Copeland The University of Texas MD Anderson Cancer Center
Nancy A. Jenkins
Nancy A. Jenkins The University of Texas MD Anderson Cancer Center

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