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Sven-Erik Dahlén

Sven-Erik Dahlén

D-Index & Metrics

Microbiology

D-Index
83
Citations
35802
World Ranking
957
National Ranking
15

Overview

Sven-Erik Dahlén is affiliated with the Karolinska Institute in Sweden and is a researcher prominently focused on respiratory medicine, particularly asthma and related respiratory diseases. Their work spans several interconnected fields including physiology, pulmonary and respiratory medicine, immunology, and molecular biology. The bulk of their publications, totaling 140, fall within the broad discipline of medicine with significant contributions to these subfields.

Their research addresses key topics centered around respiratory health and disease mechanisms, such as asthma and respiratory diseases, chronic obstructive pulmonary disease (COPD), respiratory and cough-related research, and inhalation and respiratory drug delivery. They have also conducted work on immunological pathways involving IL-33, ST2, and innate lymphoid cells (ILC), as well as allergic rhinitis, sensitization, mast cells, and histamine.

Dahlén has contributed extensively to several high-profile scientific journals. Frequent venues for their publications include:

  • Allergy
  • Journal of Allergy and Clinical Immunology
  • American Journal of Respiratory and Critical Care Medicine
  • European Respiratory Journal
  • IUPHAR/BPS Guide to Pharmacology CITE

Their collaborative network features numerous frequent co-authors, highlighting ongoing research partnerships with notable colleagues such as Ratko Djukanović, Kian Fan Chung, Ian M. Adcock, Craig E. Wheelock, and Stephen J. Fowler.

Among their recent published papers are:

  • Sputum microbiome profiles identify severe asthma phenotypes of relative stability at 12 to 18 months, 2020, Journal of Allergy and Clinical Immunology
  • Treating severe asthma: Targeting the IL-5 pathway, 2021, Clinical & Experimental Allergy
  • Airway hyperresponsiveness in asthma: The role of the epithelium, 2024, Journal of Allergy and Clinical Immunology
  • Urinary Leukotriene E4and Prostaglandin D2Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study, 2020, American Journal of Respiratory and Critical Care Medicine
  • Current perspective on eicosanoids in asthma and allergic diseases: EAACI Task Force consensus report, part I, 2020, Allergy

Their research reflects a comprehensive investigation into inflammatory pathways, biomarkers, and clinical phenotypes of severe asthma, contributing to enhanced understanding of disease mechanisms and potential therapeutic targets. These scientific contributions are situated within a clinical and molecular framework, integrating immunology and respiratory medicine.

Best Publications

  • International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

    Kian Fan Chung;Sally E. Wenzel;Jan L. Brozek;Andrew Bush

  • Leukotrienes and lipoxins: structures, biosynthesis, and biological effects

    Bengt Samuelsson;Sven-Erik Dahlén;Jan Åke Lindgren;Carol A. Rouzer

  • Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response

    S E Dahlén;J Björk;P Hedqvist;K E Arfors

  • Leukotrienes are potent constrictors of human bronchi

    Sven-Erik Dahlén;Per Hedqvist;Sven Hammarström;Bengt Samuelsson

  • Chronic rhinosinusitis in Europe : an underestimated disease. A GA²LEN study

    D Hastan;WJ Fokkens;Claus Bachert;RB Newson

  • Differential DNA Methylation in Purified Human Blood Cells: Implications for Cell Lineage and Studies on Disease Susceptibility

    Lovisa E. Reinius;Nathalie Acevedo;Maaike Joerink;Göran Pershagen

  • The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma

    B Abraham;JM Anto;E Barreiro;Ehd Bel

  • Asthma in adults and its association with chronic rhinosinusitis: The GA2LEN survey in Europe

    Deborah Jarvis;Roger Newson;Jan Lotvall;Deniz Hastan

  • Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

    Dominick E. Shaw;Ana R. Sousa;Stephen J. Fowler;Louise J. Fleming

  • The Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo

    Nan Chiang;Charles N. Serhan;Sven-Erik Dahlén;Jeffrey M. Drazen

  • Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4.

    S E Dahlén;G Hansson;P Hedqvist;T Björck

  • A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma.

    Sally E. Wenzel;Peter J. Barnes;Eugene R. Bleecker;Jean Bousquet

  • Benefits from Adding the 5-Lipoxygenase Inhibitor Zileuton to Conventional Therapy in Aspirin-intolerant Asthmatics

    Barbro Dahlén;Ewa Nizankowska;Andrew Szczeklik;Olle Zetterström

  • Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial.

    Sven-Erik Dahlén;Kerstin Malmström;Ewa Nizankowska;Barbro Dahlén

  • Identification and biological activity of novel ω-oxidized metabolites of leukotriene B4 from human leukocytes

    Göran Hansson;Jan Åke Lindgren;Sven-Erik Dahlén;Per Hedqvist

  • Urinary Excretion of Leukotriene E4 and 11-dehydro-Thromboxane B2 in Response to Bronchial Provocations with Allergen, Aspirin, Leukotriene D4, and Histamine in Asthmatics

    Maria Kumlin;Barbro Dahlén;Thure Björck;Olle Zetterström

  • Severe asthma in adults: what are the important questions?

    Pascal Chanez;Sally E. Wenzel;Gary P. Anderson;Josep M. Anto

  • International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors

    Charles Brink;Sven-Erik Dahlén;Jeffrey Drazen;Jilly F. Evans

  • Biological profile of leukotrienes C4 and D4.

    Per Hedqvist;Sven-Erik Dahlén;Lars Gustafsson;Sven Hammarström

  • Application of 'omics technologies to biomarker discovery in inflammatory lung diseases.

    Craig E. Wheelock;Victoria M. Goss;David Balgoma;Ben Nicholas

  • Isolated bronchi from asthmatics are hyperresponsive to adenosine, which apparently acts indirectly by liberation of leukotrienes and histamine.

    Thure Björck;Lars E. Gustafsson;Sven-Erik Dahlén

Frequent Co-Authors

Barbro Dahlén
Barbro Dahlén Karolinska Institute
Craig E. Wheelock
Craig E. Wheelock Karolinska Institute
Peter J. Sterk
Peter J. Sterk University of Amsterdam
Ratko Djukanovic
Ratko Djukanovic University of Southampton
Ian M. Adcock
Ian M. Adcock Imperial College London
Kian Fan Chung
Kian Fan Chung Imperial College London
Gunilla Hedlin
Gunilla Hedlin Karolinska Institute
Peter H. Howarth
Peter H. Howarth University of Southampton
Charles Auffray
Charles Auffray Centre national de la recherche scientifique, CNRS
Pascal Chanez
Pascal Chanez Aix-Marseille University

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