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Chemistry

D-Index
52
Citations
9318
World Ranking
13549
National Ranking
239

Overview

Denis Barron is a researcher affiliated with Nestlé (Switzerland) in Switzerland. Their scholarly work spans key areas in Medicine and Biochemistry, Genetics and Molecular Biology, with particular attention to molecular and cellular mechanisms underpinning metabolism and therapeutic interventions.

The main fields of study for Barron include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Their research further delves into subfields such as Molecular Biology, Biochemistry, Physiology, Pharmacology, and Computational Theory and Mathematics.

  • Molecular Biology
  • Biochemistry
  • Physiology
  • Pharmacology
  • Computational Theory and Mathematics

Barron's work explores a set of interconnected topics within biomedical science, including:

  • Phytochemicals and Antioxidant Activities
  • Computational Drug Discovery Methods
  • Mitochondrial Function and Pathology
  • Adipose Tissue and Metabolism
  • Biological and pharmacological studies of plants
  • Plant Gene Expression Analysis
  • Tea Polyphenols and Effects

The scientist has contributed to multiple peer-reviewed articles covering aspects of therapeutic effects and molecular biology mechanisms. Notable recent publications include:

  • "Network medicine framework shows that proximity of polyphenol targets and disease proteins predicts therapeutic effects of polyphenols," 2021, Nature Food
  • "Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance," 2024, Cell Metabolism
  • "Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite-binding site," 2022, Journal of Biological Chemistry
  • "Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance regenerative capacity during aging," 2024, Journal of Clinical Investigation
  • "Network Medicine Framework Shows Proximity of Polyphenol Targets and Disease Proteins is Predictive of the Therapeutic Effects of Polyphenols," 2020, bioRxiv (Cold Spring Harbor Laboratory)

These publications have appeared primarily in journals such as bioRxiv (Cold Spring Harbor Laboratory), Journal of Agricultural and Food Chemistry, Nature Food, Cell Metabolism, and Journal of Biological Chemistry.

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Agricultural and Food Chemistry
  • Nature Food
  • Cell Metabolism
  • Journal of Biological Chemistry

Throughout their research career, Barron has collaborated frequently with several peers, with co-authorship counts indicating repeated partnerships. Frequent coauthors include:

  • Benjamin Brinon
  • Eugenia Migliavacca
  • Guillaume Jacot
  • Jérôme N. Feige
  • Matthew J. Sanders

Best Publications

  • Human metabolism of dietary flavonoids: Identification of plasma metabolites of quercetin

    Andrea J. Day;Fred Mellon;Denis Barron;Géraldine Sarrazin

  • The Arabidopsis MATE Transporter TT12 Acts as a Vacuolar Flavonoid /H+ -Antiporter Active in Proanthocyanidin-Accumulating Cells of the Seed Coat

    Krasimira Marinova;Lucille Pourcel;Barbara Weder;Michael Schwarz

  • Flavonoids: A class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein

    Gwenaelle Conseil;Helene Baubichon-Cortay;Guila Dayan;Jean-Michel Jault

  • Metabolite Profiling of Hydroxycinnamate Derivatives in Plasma and Urine after the Ingestion of Coffee by Humans: Identification of Biomarkers of Coffee Consumption

    Angélique Stalmach;William Mullen;Denis Barron;Kenichi Uchida

  • Bioavailability Is Improved by Enzymatic Modification of the Citrus Flavonoid Hesperidin in Humans: A Randomized, Double-Blind, Crossover Trial

    Inge Lise F. Nielsen;Winnie S.S. Chee;Lea Poulsen;Elizabeth Offord-Cavin

  • Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters.

    A. Di Pietro;G. Conseil;J.M. Pérez-Victoria;G. Dayan

  • Isoprenylated flavonoids—a survey

    Denis Barron;Ragai K. Ibrahim

  • In vitro biological properties of flavonoid conjugates found in vivo

    Gary Williamson;D. Barron;K. Shimoi;J. Terao

  • Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance

    Ahcène Boumendjel;Attilio Di Pietro;Charles Dumontet;Denis Barron

  • Two diastereomeric 3-oxo-α-ionol β-d-glucosides from raspberry fruit

    Anni Pabst;Denis Barron;Denis Barron;Etienne Sémon;Etienne Sémon;Peter Schreier

  • Sulphated flavonoids: an update

    Denis Barron;Luc Varin;Ragai K. Ibrahim;Jeffrey B. Harborne;Jeffrey B. Harborne

  • A comparison of the in vitro biotransformation of (-)-epicatechin and procyanidin B2 by human faecal microbiota.

    Stavroula Stoupi;Gary Williamson;Gary Williamson;J. Warren Drynan;Denis Barron

  • Metabolism and transport of the citrus flavonoid hesperetin in Caco-2 cell monolayers.

    Walter Brand;Petronella A. I. van der Wel;Maarit J. Rein;Denis Barron

  • Effects of flavonoids on cell proliferation and caspase activation in a human colonic cell line HT29: an SAR study.

    Jean-Baptiste Daskiewicz;Flore Depeint;Lionel Viornery;Christine Bayet

  • In vivo bioavailability, absorption, excretion, and pharmacokinetics of [14C]procyanidin B2 in male rats.

    Stavroula Stoupi;Gary Williamson;Florian Viton;Denis Barron

  • Elucidation of (-)-epicatechin metabolites after ingestion of chocolate by healthy humans.

    Lucas Actis-Goretta;Antoine Lévèques;Francesca Giuffrida;Fedor Romanov-Michailidis

  • Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK

    Roger W. Hunter;Roger W. Hunter;Marc Foretz;Marc Foretz;Marc Foretz;Laurent Bultot;Morgan D. Fullerton

  • C-Isoprenylation of flavonoids enhances binding affinity toward P-glycoprotein and modulation of cancer cell chemoresistance.

    Gilles Comte;# Jean-Baptiste Daskiewicz;Christine Bayet;Gwenaëlle Conseil

  • Measurement of caffeic and ferulic acid equivalents in plasma after coffee consumption: Small intestine and colon are key sites for coffee metabolism

    Mathieu Renouf;Philippe A. Guy;Cynthia Marmet;Anne Lise Fraering

  • Absorption, conjugation and excretion of the flavanones, naringenin and hesperetin from α-rhamnosidase-treated orange juice in human subjects.

    Lea Bredsdorff;Inge Lise F. Nielsen;Salka E. Rasmussen;Claus Cornett

Frequent Co-Authors

Gary Williamson
Gary Williamson Monash University
Albert-László Barabási
Albert-László Barabási Northeastern University
Jean-Luc Veuthey
Jean-Luc Veuthey University of Geneva
Davy Guillarme
Davy Guillarme University of Geneva
Joseph Loscalzo
Joseph Loscalzo Harvard Medical School
Peter J. van Bladeren
Peter J. van Bladeren Nestlé (Switzerland)
Philippe A. Guy
Philippe A. Guy Nestlé (Switzerland)
Kei Sakamoto
Kei Sakamoto University of Copenhagen
Attilio Di Pietro
Attilio Di Pietro University of Lyon System
Alan Crozier
Alan Crozier University of California, Davis

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