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Biology and Biochemistry

D-Index
69
Citations
14852
World Ranking
7509
National Ranking
19

Research.com Recognitions

  • 2013 - Fellow, The World Academy of Sciences

Overview

Helena B. Nader is affiliated with the Federal University of Sao Paulo in Brazil. The primary research focus lies in biochemistry, genetics, and molecular biology, with significant contributions also in medicine. The work spans several subfields including molecular biology, cell biology, infectious diseases, surgery, and epidemiology.

The scientist's research primarily addresses topics such as proteoglycans and glycosaminoglycans, glycosylation and glycoproteins, and the clinical and molecular aspects of COVID-19, including SARS-CoV-2 studies. Additional areas include angiogenesis and vascular endothelial growth factor (VEGF) in cancer, cell adhesion molecules, and cellular transport and secretion mechanisms.

Frequent collaborators have included:

  • Maria Cecília Zorél Meneghetti
  • Marcelo A. Lima
  • Maria Aparecida da Silva Pinhal
  • Renan P. Cavalheiro
  • Edwin A. Yates

Prominent venues for publication comprise the International Journal of Molecular Sciences, bioRxiv (Cold Spring Harbor Laboratory), ACS Applied Bio Materials, Advances in Experimental Medicine and Biology, and Thrombosis and Haemostasis.

Recent publications include:

  • Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin, 2020, Thrombosis and Haemostasis
  • Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Altered shear stress on endothelial cells leads to remodeling of extracellular matrix and induction of angiogenesis, 2020, PLoS ONE
  • Heparan sulfate proteoglycans as targets for cancer therapy: a review, 2020, Cancer Biology & Therapy
  • MicroRNA-1252-5p Associated with Extracellular Vesicles Enhances Bortezomib Sensitivity in Multiple Myeloma Cells by Targeting Heparanase, 2021, OncoTargets and Therapy

Helena B. Nader has published a book titled Relações do conhecimento entre arte e ciência: gênero, neocolonialismo e espaço sideral: volume 2 in 2022, made available by Universidade de São Paulo. Instituto de Estudos Avançados eBooks.

An award recognises this scientist as a Fellow of The World Academy of Sciences since 2013.

Best Publications

  • Heparan sulfate proteoglycans: structure, protein interactions and cell signaling

    Juliana Luporini Dreyfuss;Caio Vinicius Saito Regatieri;Thais R. Jarrouge;Renan Pelluzzi Cavalheiro

  • Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin.

    Courtney J. Mycroft-West;Dunhao Su;Isabel Pagani;Timothy R. Rudd

  • Heparan sulfate and heparin interactions with proteins

    Maria C. Z. Meneghetti;Ashley J. Hughes;Timothy R. Rudd;Helena B. Nader

  • Cysteine Cathepsins in Human Carious Dentin

    F.D. Nascimento;C.L. Minciotti;S. Geraldeli;M.R. Carrilho

  • Cathepsin B Activity Regulation HEPARIN-LIKE GLYCOSAMINOGLYCANS PROTECT HUMAN CATHEPSIN B FROM ALKALINE pH-INDUCED INACTIVATION

    P. C. Almeida;I. L. Nantes;Jair Ribeiro Chagas;Cca Rizzi

  • Heparin sequences in the heparan sulfate chains of an endothelial cell proteoglycan.

    H B Nader;C P Dietrich;V Buonassisi;P Colburn

  • Purification and substrate specificity of heparitinase I and heparitinase II from Flavobacterium heparinum. Analyses of the heparin and heparan sulfate degradation products by 13C NMR spectroscopy.

    H. B. Nader;M. A. Porcionatto;I. L. S. Tersariol;M. A. Pinhal

  • Recovery of protein, chitin, carotenoids and glycosaminoglycans from Pacific white shrimp (Litopenaeus vannamei) processing waste

    Thiago B. Cahú;Suzan D. Santos;Aline Mendes;Carolina R. Córdula

  • Structural and hemostatic activities of a sulfated galactofucan from the brown alga Spatoglossum schroederi. An ideal antithrombotic agent

    Hugo A.O. Rocha;Fábio A. Moraes;Edvaldo S. Trindade;Célia R.C. Franco

  • Distribution of sulfated glycosaminoglycans in the animal kingdom: widespread occurrence of heparin-like compounds in invertebrates.

    Guilherme F. Medeiros;Aline Mendes;Ricardo A.B. Castro;Elaine C. Baú

  • Abundance of MMPs and Cysteine Cathepsins in Caries-affected Dentin

    C.M.P. Vidal;L. Tjäderhane;L. Tjäderhane;P.M. Scaffa;I.L. Tersariol;I.L. Tersariol

  • Structural differences of heparan sulfates according to the tissue and species of origin

    Carl P. Dietrich;Helena B. Nader;Anita H. Straus

  • Brown spider dermonecrotic toxin directly induces nephrotoxicity

    Olga Meiri Chaim;Youssef Bacila Sade;Rafael Bertoni da Silveira;Leny Toma

  • Heparin stimulates the synthesis and modifies the sulfation pattern of heparan sulfate proteoglycan from endothelial cells

    Helena B. Nader;Vincenzo Buonassisi;Patricia Colburn;Carl P. Dietrich

  • Fractionation and properties of four heparitin sulfates from beef lung tissue. Isolation and partial characterization of a hemogeneous species of heparitin sulfate.

    Carl.P. Dietrich;Helena B. Nader

  • Heparins and Heparinoids: Occurrence, Structure and Mechanism of Antithrombotic and Hemorrhagic Activities

    Helena Bonciani Nader;Carla C. Lopes;Hugo Alexande de Oliveira Rocha;Elizeu Antunes dos Santos

  • Structure and Antithrombin-Binding Properties of Heparin Isolated From the Clams Anomalocardia Brasiliana and Tivela Mactroides

    Gunnar Pejler;Ake Danielsson;Ingemar Bjork;Ulf Lindahl

  • Structure and pharmacological activities of a sulfated xylofucoglucuronan from the alga Spatoglossum schröederi

    Edda L Leite;Edda L Leite;Maria G.L Medeiros;Maria G.L Medeiros;Hugo A.O Rocha;Hugo A.O Rocha;Guacyra G.M Farias;Guacyra G.M Farias

  • Crotamine mediates gene delivery into cells through the binding to heparan sulfate proteoglycans

    Fábio Dupart Nascimento;Mirian A. F. Hayashi;Alexandre Kerkis;Vitor Oliveira

  • A preponderantly 4-sulfated, 3-linked galactan from the green alga Codium isthmocladum.

    Eduardo H C Farias;Vitor H Pomin;Ana-Paula Valente;Helena B Nader

Frequent Co-Authors

Jawed Fareed
Jawed Fareed Loyola University Chicago
Manuel Simões
Manuel Simões University of Porto
Guilherme L. Sassaki
Guilherme L. Sassaki Federal University of Paraná
Giangiacomo Torri
Giangiacomo Torri Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni
Luiz Juliano
Luiz Juliano Federal University of Sao Paulo
Marco Guerrini
Marco Guerrini Istituto G. Ronzoni
Ricardo R. Brentani
Ricardo R. Brentani Ludwig Cancer Research
Paulo A.S. Mourão
Paulo A.S. Mourão Federal University of Rio de Janeiro
Maria da Graça Naffah-Mazzacoratti
Maria da Graça Naffah-Mazzacoratti Federal University of Sao Paulo
Renato D. Lopes
Renato D. Lopes Duke University

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