What is he best known for?
The fields of study he is best known for:
- Signal transduction
- G protein-coupled receptor
- Amino acid
G protein, Biochemistry, Cell biology, RGS Proteins and GTPase-activating protein are his primary areas of study.
His research in G protein is mostly focused on Heterotrimeric G protein.
His Heterotrimeric G protein study combines topics in areas such as G protein-coupled receptor and Effector.
As a part of the same scientific study, John R. Hepler usually deals with the Biochemistry, concentrating on G alpha subunit and frequently concerns with Gi alpha subunit, Alpha, Molecular biology and ADCY9.
His research integrates issues of Receptor and Vesicle-associated membrane protein 8 in his study of Cell biology.
His research in GTPase-activating protein focuses on subjects like RGS4, which are connected to Protein structure.
His most cited work include:
- Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq (768 citations)
- Cellular Regulation of RGS Proteins: Modulators and Integrators of G Protein Signaling (630 citations)
- RGS4 and GAIP are GTPase-activating proteins for Gqα and block activation of phospholipase Cβ by γ-thio-GTP-Gqα (333 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of study are Cell biology, G protein, Biochemistry, RGS Proteins and RGS14.
His study in GTPase-activating protein, Heterotrimeric G protein, Regulator of G protein signaling, G protein-coupled receptor and G beta-gamma complex falls within the category of Cell biology.
His cAMP-dependent pathway study, which is part of a larger body of work in G protein, is frequently linked to Palmitoylation, bridging the gap between disciplines.
His work deals with themes such as Molecular biology, Alpha and G alpha subunit, which intersect with Biochemistry.
He has included themes like Plasma protein binding, GTPase, RGS2, RGS4 and Computational biology in his RGS Proteins study.
His RGS14 research includes themes of Synaptic plasticity, Protein kinase A, Binding domain, Scaffold protein and Nuclear localization sequence.
He most often published in these fields:
- Cell biology (59.00%)
- G protein (42.00%)
- Biochemistry (37.00%)
What were the highlights of his more recent work (between 2016-2021)?
- Cell biology (59.00%)
- RGS14 (33.00%)
- G protein (42.00%)
In recent papers he was focusing on the following fields of study:
His main research concerns Cell biology, RGS14, G protein, Regulator of G protein signaling and Synaptic plasticity.
His study looks at the intersection of Cell biology and topics like Calmodulin with Membrane protein and Calcium in biology.
His study on RGS14 also encompasses disciplines like
- Schaffer collateral, Calcium signaling and NMDA receptor most often made with reference to Ca2+/calmodulin-dependent protein kinase,
- Nuclear localization sequence together with Gi alpha subunit.
His G protein and RGS Proteins and Heterotrimeric G protein investigations all form part of his G protein research activities.
His study looks at the relationship between RGS Proteins and fields such as Computational biology, as well as how they intersect with chemical problems.
His Heterotrimeric G protein research focuses on GTPase and how it relates to RGS4.
Between 2016 and 2021, his most popular works were:
- Genetic Analysis of Rare Human Variants of Regulators of G Protein Signaling Proteins and Their Role in Human Physiology and Disease. (21 citations)
- RGS14 Restricts Plasticity in Hippocampal CA2 by Limiting Postsynaptic Calcium Signaling (19 citations)
- Direct visualization of interaction between calmodulin and connexin45. (13 citations)
In his most recent research, the most cited papers focused on:
- Amino acid
- Signal transduction
- G protein-coupled receptor
John R. Hepler mostly deals with Cell biology, RGS14, Calmodulin, Ca2+/calmodulin-dependent protein kinase and RGS Proteins.
His research combines Membrane protein and Cell biology.
His studies deal with areas such as Caudate nucleus, Neuron and Putamen as well as RGS14.
His Calmodulin research incorporates elements of Protein kinase A, Scaffold protein, Regulator of G protein signaling, CAMK and Peptide.
His RGS Proteins study contributes to a more complete understanding of Receptor.
His Missense mutation research spans across into fields like G protein and Computational biology.
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