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John R. Hepler

D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
11892
World Ranking
17010
National Ranking
7010

John R. Hepler publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where John R. Hepler sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 413 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 848 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 949 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 840 scientists 207–216 publications: 733 scientists 217–226 publications: 708 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 417 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 196 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 59 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 130 publications — 17th percentile

17% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

John R. Hepler D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where John R. Hepler sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 316 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 899 scientists 52–53 D-Index: 1,025 scientists 54–55 D-Index: 1,149 scientists 56–57 D-Index: 1,235 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,162 scientists 62–63 D-Index: 1,130 scientists 64–65 D-Index: 1,031 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 714 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 71 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 51 D-Index — 14th percentile

14% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2014 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

John R. Hepler is affiliated with Emory University in the United States. Their research spans multiple domains within biochemistry, genetics, molecular biology, and neuroscience. The scientist's work primarily focuses on molecular biology and cellular and molecular neuroscience, with additional contributions in nephrology, genetics, and physiology.

Their research topics include:

  • Neuroscience and Neuropharmacology Research
  • Receptor Mechanisms and Signaling
  • Protein Kinase Regulation and GTPase Signaling
  • Parathyroid Disorders and Treatments
  • Neurotransmitter Receptor Influence on Behavior
  • Mitochondrial Function and Pathology
  • Genetics and Neurodevelopmental Disorders

They have published extensively in several venues, the most frequent being:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • IUPHAR/BPS Guide to Pharmacology CITE
  • British Journal of Pharmacology
  • Journal of Biological Chemistry
  • Hippocampus

The scientist has authored and co-authored papers such as:

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets, 2021, British Journal of Pharmacology
  • The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets, 2023, British Journal of Pharmacology
  • RGS14 Regulation of Post-Synaptic Signaling and Spine Plasticity in Brain, 2021, International Journal of Molecular Sciences
  • RGS14 regulates PTH- and FGF23-sensitive NPT2A-mediated renal phosphate uptake via binding to the NHERF1 scaffolding protein, 2022, Journal of Biological Chemistry
  • Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons, 2020, Journal of Biological Chemistry

Frequent co-authors in their work include:

  • Carolina Montañez-Miranda
  • Nicholas H. Harbin
  • Katherine E. Squires
  • David Weinshenker
  • Kyle J. Gerber

John R. Hepler's contributions cross interdisciplinary lines, integrating molecular biology methods with neuroscience research to explore receptor signaling, synaptic plasticity, and renal phosphate uptake mechanisms. Their work has appeared in venues that emphasize both pharmacology and biological chemistry.

Recognition for their scientific contributions includes being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2014.

Best Publications

  • Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq

    Alan V. Smrcka;John R. Hepler;Kendall O. Brown;Paul C. Sternweis

  • Cellular Regulation of RGS Proteins: Modulators and Integrators of G Protein Signaling

    Susanne Hollinger;John R. Hepler

  • RGS4 and GAIP are GTPase-activating proteins for Gqα and block activation of phospholipase Cβ by γ-thio-GTP-Gqα

    John R. Hepler;David M. Berman;Alfred G. Gilman;Tohru Kozasa

  • Lipid modifications of G proteins: alpha subunits are palmitoylated.

    Maurine E. Linder;Pamela Middleton;John R. Hepler;Ronald Taussig

  • Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.

    Ronald Taussig;Wei Jen Tang;John R. Hepler;Alfred G. Gilman

  • RGS2/G0S8 is a selective inhibitor of Gqα function

    Scott P. Heximer;Ned Watson;Maurine E. Linder;Kendall J. Blumer

  • Emerging roles for RGS proteins in cell signalling

    John R Hepler

  • Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits.

    John R. Hepler;Tohru Kozasa;Alan V. Smrcka;Melvin I. Simon

  • Cell signalling diversity of the Gqα family of heterotrimeric G proteins

    Katherine B. Hubbard;John R. Hepler

  • Organization of G proteins and adenylyl cyclase at the plasma membrane

    Chunfa Huang;John R. Hepler;Linda T. Chen;Alfred G. Gilman

  • RGS2 Binds Directly and Selectively to the M1 Muscarinic Acetylcholine Receptor Third Intracellular Loop to Modulate Gq/11α Signaling

    Leah S. Bernstein;Suneela Ramineni;Chris Hague;Wendy Cladman

  • Characterization of antisera to glutamate and aspartate.

    J R Hepler;C S Toomim;K D McCarthy;F Conti

  • Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization.

    J R Hepler;H S Earp;T K Harden

  • Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes.

    Scott D. Sorensen;Olivier Nicole;Richard D. Peavy;Lisa M. Montoya

  • RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory

    Sarah Emerson Lee;Stephen B. Simons;Scott A. Heldt;Meilan Zhao

  • G Protein Selectivity Is a Determinant of RGS2 Function

    Scott P. Heximer;Sreesha P. Srinivasa;Leah S. Bernstein;Jennifer L. Bernard

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets.

    Stephen Ph Alexander;Eamonn Kelly;Alistair Mathie;John A Peters

  • Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells.

    J. R. Hepler;N. Nakahata;T. W. Lovenberg;J. D. DiGuiseppi

  • Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells

    Chunfa Huang;John R. Hepler;Alfred G. Gilman;Susanne M. Mumby

  • Activation of phospholipase C-beta 2 mutants by G protein alpha q and beta gamma subunits.

    Sang Bong Lee;Seok Hwan Shin;John R. Hepler;Alfred G. Gilman

Frequent Co-Authors

Alfred G. Gilman
Alfred G. Gilman The University of Texas Southwestern Medical Center
Stephen F. Traynelis
Stephen F. Traynelis Emory University
Nicholas T. Seyfried
Nicholas T. Seyfried Emory University
T. Kendall Harden
T. Kendall Harden University of North Carolina at Chapel Hill
Alan V. Smrcka
Alan V. Smrcka University of Michigan–Ann Arbor
Patrick R. Griffin
Patrick R. Griffin Scripps Research Institute
C. Justin Lee
C. Justin Lee Institute for Basic Science
Paul C. Sternweis
Paul C. Sternweis The University of Texas Southwestern Medical Center
Yoland Smith
Yoland Smith Emory University
Kirill A. Martemyanov
Kirill A. Martemyanov Scripps Research Institute

External Links

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