John R. Hepler

Research.com Recognitions

• 2014 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Best Publications

• Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq

  Alan V. Smrcka;John R. Hepler;Kendall O. Brown;Paul C. Sternweis

  1123
  Citations

• Cellular Regulation of RGS Proteins: Modulators and Integrators of G Protein Signaling

  Susanne Hollinger;John R. Hepler

  862
  Citations

• RGS4 and GAIP are GTPase-activating proteins for Gqα and block activation of phospholipase Cβ by γ-thio-GTP-Gqα

  John R. Hepler;David M. Berman;Alfred G. Gilman;Tohru Kozasa

  481
  Citations

• Lipid modifications of G proteins: alpha subunits are palmitoylated.

  Maurine E. Linder;Pamela Middleton;John R. Hepler;Ronald Taussig

  458
  Citations

• Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.

  Ronald Taussig;Wei Jen Tang;John R. Hepler;Alfred G. Gilman

  443
  Citations

• RGS2/G0S8 is a selective inhibitor of Gqα function

  Scott P. Heximer;Ned Watson;Maurine E. Linder;Kendall J. Blumer

  439
  Citations

• Emerging roles for RGS proteins in cell signalling

  John R Hepler

  348
  Citations

• Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits.

  John R. Hepler;Tohru Kozasa;Alan V. Smrcka;Melvin I. Simon

  340
  Citations

• Cell signalling diversity of the Gqα family of heterotrimeric G proteins

  Katherine B. Hubbard;John R. Hepler

  340
  Citations

• Organization of G proteins and adenylyl cyclase at the plasma membrane

  Chunfa Huang;John R. Hepler;Linda T. Chen;Alfred G. Gilman

  274
  Citations

• RGS2 Binds Directly and Selectively to the M1 Muscarinic Acetylcholine Receptor Third Intracellular Loop to Modulate Gq/11α Signaling

  Leah S. Bernstein;Suneela Ramineni;Chris Hague;Wendy Cladman

  271
  Citations

• Characterization of antisera to glutamate and aspartate.

  J R Hepler;C S Toomim;K D McCarthy;F Conti

  238
  Citations

• Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization.

  J R Hepler;H S Earp;T K Harden

  237
  Citations

• Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes.

  Scott D. Sorensen;Olivier Nicole;Richard D. Peavy;Lisa M. Montoya

  237
  Citations

• RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory

  Sarah Emerson Lee;Stephen B. Simons;Scott A. Heldt;Meilan Zhao

  216
  Citations

• G Protein Selectivity Is a Determinant of RGS2 Function

  Scott P. Heximer;Sreesha P. Srinivasa;Leah S. Bernstein;Jennifer L. Bernard

  212
  Citations

• THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets.

  Stephen Ph Alexander;Eamonn Kelly;Alistair Mathie;John A Peters

  212
  Citations

• Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells.

  J. R. Hepler;N. Nakahata;T. W. Lovenberg;J. D. DiGuiseppi

  212
  Citations

• Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells

  Chunfa Huang;John R. Hepler;Alfred G. Gilman;Susanne M. Mumby

  210
  Citations

• Activation of phospholipase C-beta 2 mutants by G protein alpha q and beta gamma subunits.

  Sang Bong Lee;Seok Hwan Shin;John R. Hepler;Alfred G. Gilman

  181
  Citations