Ed Manser

Overview

Best Publications

• A brain serine/threonine protein kinase activated by Cdc42 and Rac1.

  Edward Manser;Thomas Leung;Harfizah Salihuddin;Zhuo-shen Zhao

  1951
  Citations

• The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton.

  T Leung;X Q Chen;E Manser;L Lim

  1152
  Citations

• A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes

  Thomas Leung;Edward Manser;Lydia Tan;Louis Lim

  1004
  Citations

• PAK kinases are directly coupled to the PIX family of nucleotide exchange factors.

  Edward Manser;Tsui-Han Loo;Cheng-Gee Koh;Zhou-Shen Zhao

  951
  Citations

• Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

  E Manser;H Y Huang;T H Loo;X Q Chen

  758
  Citations

• Rho GTPases and their role in organizing the actin cytoskeleton.

  Soon-Tuck Sit;Ed Manser

  598
  Citations

• Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast.

  F Cvrcková;C De Virgilio;E Manser;J R Pringle

  502
  Citations

• Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly.

  Zhou-shen Zhao;Edward Manser;Tsui-Han Loo;Louis Lim

  489
  Citations

• A Conserved Negative Regulatory Region in αPAK: Inhibition of PAK Kinases Reveals Their Morphological Roles Downstream of Cdc42 and Rac1

  Zhou-Shen Zhao;Edward Manser;Xiang-Qun Chen;Claire Chong

  420
  Citations

• A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42.

  Edward Manser;Thomas Leung;Harfizah Salihuddin;Lydia Tan

  409
  Citations

• Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways.

  Louis Lim;Edward Manser;Thomas Leung;Christine Hall

  403
  Citations

• PRL-3 and PRL-1 promote cell migration, invasion, and metastasis.

  Qi Zeng;Jing-Ming Dong;Ke Guo;Jie Li

  391
  Citations

• Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization.

  Thomas Leung;Xiang-Qun Chen;Ivan Tan;Edward Manser

  370
  Citations

• PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation.

  Zhou-shen Zhao;Ed Manser

  348
  Citations

• cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKalpha.

  Jing-Ming Dong;Thomas Leung;Edward Manser;Louis Lim;Louis Lim

  334
  Citations

• PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition.

  Haihe Wang;Samantha Yiling Quah;Jing Ming Dong;Edward Manser

  325
  Citations

• Molecular Cloning of a New Member of the p21-Cdc42/Rac-activated Kinase (PAK) Family

  Edward Manser;Claire Chong;Zhuo-Shen Zhao;Thomas Leung

  323
  Citations

• The Mechanism of PAK Activation AUTOPHOSPHORYLATION EVENTS IN BOTH REGULATORY AND KINASE DOMAINS CONTROL ACTIVITY

  Claire Chong;Lydia Tan;Louis Lim;Edward Manser

  320
  Citations

• A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures.

  N. Harden;J. Lee;Hui-Yong Loh;Yong-Mei Ong

  300
  Citations

• PAK promotes morphological changes by acting upstream of Rac.

  Axel Obermeier;Sohail Ahmed;Sohail Ahmed;Edward Manser;Su Ching Yen

  300
  Citations