H-Index & Metrics Best Publications
Toshimasa Ishizaki

Toshimasa Ishizaki

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 43 Citations 19,531 64 World Ranking 14715 National Ranking 1049

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • DNA
  • Biochemistry

His primary areas of investigation include Cell biology, Rho-associated protein kinase, Protein kinase A, MDia1 and Actin. Toshimasa Ishizaki regularly links together related areas like 3T3 cells in his Cell biology studies. When carried out as part of a general Rho-associated protein kinase research project, his work on ROCK2 is frequently linked to work in Centralspindlin complex and Cleavage furrow ingression, therefore connecting diverse disciplines of study.

He works mostly in the field of Protein kinase A, limiting it down to topics relating to Molecular biology and, in certain cases, ROCK1, Serine/threonine-specific protein kinase and Kinase, as a part of the same area of interest. His study with MDia1 involves better knowledge in Actin cytoskeleton. The concepts of his Actin study are interwoven with issues in DAAM1, Formins and Mitosis.

His most cited work include:

  • Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension (2562 citations)
  • Focal Contacts as Mechanosensors Externally Applied Local Mechanical Force Induces Growth of Focal Contacts by an Mdia1-Dependent and Rock-Independent Mechanism (1220 citations)
  • The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. (794 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Cell biology, MDia1, Actin, Molecular biology and Actin cytoskeleton. His study in the field of Rho-associated protein kinase, Focal adhesion and Small GTPase is also linked to topics like Cleavage furrow. His research in Rho-associated protein kinase tackles topics such as Protein kinase A which are related to areas like Binding site.

His work carried out in the field of MDia1 brings together such families of science as Formins, Muscle hypertrophy, Cell migration and Actin remodeling. His Molecular biology research is multidisciplinary, incorporating elements of Kinase, Pleckstrin homology domain and Serine/threonine-specific protein kinase. His Actin cytoskeleton research includes elements of Stress fiber and Cell polarity.

He most often published in these fields:

  • Cell biology (69.51%)
  • MDia1 (26.83%)
  • Actin (20.73%)

What were the highlights of his more recent work (between 2014-2021)?

  • Cell biology (69.51%)
  • Endocytosis (8.54%)
  • MDia1 (26.83%)

In recent papers he was focusing on the following fields of study:

Toshimasa Ishizaki focuses on Cell biology, Endocytosis, MDia1, Insulin and Exocytosis. Cell biology connects with themes related to Paracrine Communication in his study. His Endocytosis research is multidisciplinary, incorporating perspectives in GTPase-activating protein, Pancreatic beta Cells and Gene knockdown.

His MDia1 study deals with Heart failure intersecting with Signal transduction, Mechanotransduction and Actin cytoskeleton. In his research, Guanosine triphosphate, Guanosine diphosphate and Rab is intimately related to Endocytic cycle, which falls under the overarching field of Exocytosis. His work on Protein kinase A as part of general Phosphorylation research is often related to ZAP70, thus linking different fields of science.

Between 2014 and 2021, his most popular works were:

  • Protective effect of hydrogen sulfide on pancreatic beta-cells (15 citations)
  • PI3K regulates endocytosis after insulin secretion by mediating signaling crosstalk between Arf6 and Rab27a. (13 citations)
  • Interplay between Rab27a effectors in pancreatic β-cells (9 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • DNA
  • Biochemistry

Toshimasa Ishizaki spends much of his time researching Cell biology, GTPase, GTP', Small GTPase and Rab. His specific area of interest is Cell biology, where Toshimasa Ishizaki studies Cell signaling. The GTPase study combines topics in areas such as Guanosine diphosphate, Guanosine triphosphate, Guanosine and Effector.

Many of his studies involve connections with topics such as Endocytic cycle and Guanosine. His Endocytic cycle study combines topics in areas such as Secretion, PI3K/AKT/mTOR pathway, Crosstalk and Clathrin. His research combines IQGAP1 and GTP'.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

Masayoshi Uehata;Toshimasa Ishizaki;Hiroyuki Satoh;Takashi Ono.
Nature (1997)

3474 Citations

Focal Contacts as Mechanosensors Externally Applied Local Mechanical Force Induces Growth of Focal Contacts by an Mdia1-Dependent and Rock-Independent Mechanism

Daniel Riveline;Daniel Riveline;Eli Zamir;Nathalie Q. Balaban;Ulrich S. Schwarz.
Journal of Cell Biology (2001)

1660 Citations

Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

Naoki Watanabe;Takayuki Kato;Akiko Fujita;Toshimasa Ishizaki.
Nature Cell Biology (1999)

1027 Citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

Toshimasa Ishizaki;Midori Maekawa;Kazuko Fujisawa;Katsuya Okawa.
The EMBO Journal (1996)

1021 Citations

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin.

Naoki Watanabe;Pascal Madaule;Tim Reid;Toshimasa Ishizaki.
The EMBO Journal (1997)

984 Citations

ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice

Osamu Nakagawa;Kazuko Fujisawa;Toshimasa Ishizaki;Yuji Saito.
FEBS Letters (1996)

965 Citations

Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion.

Shuh Narumiya;Masahiro Tanji;Toshimasa Ishizaki.
Cancer and Metastasis Reviews (2009)

609 Citations

p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions

Toshimasa Ishizaki;Mamoru Naito;Kazuko Fujisawa;Midori Maekawa.
FEBS Letters (1997)

603 Citations

Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho

Go Watanabe;Yuji Saito;Pascal Madaule;Toshimasa Ishizaki.
Science (1996)

563 Citations

Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells

Masaya Hirose;Toshimasa Ishizaki;Naoki Watanabe;Masayoshi Uehata.
Journal of Cell Biology (1998)

535 Citations

If you think any of the details on this page are incorrect, let us know.

Contact us

Best Scientists Citing Toshimasa Ishizaki

Kozo Kaibuchi

Kozo Kaibuchi

Nagoya University

Publications: 134

Hiroaki Shimokawa

Hiroaki Shimokawa

Tohoku University

Publications: 72

James K. Liao

James K. Liao

University of Chicago

Publications: 63

Shuh Narumiya

Shuh Narumiya

Kyoto University

Publications: 61

Alexander D. Bershadsky

Alexander D. Bershadsky

National University of Singapore

Publications: 59

Mutsuki Amano

Mutsuki Amano

Nagoya University

Publications: 58

Anne J. Ridley

Anne J. Ridley

University of Bristol

Publications: 56

Michael P. Sheetz

Michael P. Sheetz

The University of Texas Medical Branch at Galveston

Publications: 56

Donald E. Ingber

Donald E. Ingber

Harvard University

Publications: 46

Benjamin Geiger

Benjamin Geiger

Weizmann Institute of Science

Publications: 44

Louis Lim

Louis Lim

University College London

Publications: 36

Keith Burridge

Keith Burridge

University of North Carolina at Chapel Hill

Publications: 34

Christopher S. Chen

Christopher S. Chen

Boston University

Publications: 33

Michael F. Olson

Michael F. Olson

Toronto Metropolitan University

Publications: 33

Lei Wei

Lei Wei

Wuhan University

Publications: 31

Alan Hall

Alan Hall

Memorial Sloan Kettering Cancer Center

Publications: 30

Something went wrong. Please try again later.