His primary areas of investigation include Cell biology, Rho-associated protein kinase, Protein kinase A, MDia1 and Actin. Toshimasa Ishizaki regularly links together related areas like 3T3 cells in his Cell biology studies. When carried out as part of a general Rho-associated protein kinase research project, his work on ROCK2 is frequently linked to work in Centralspindlin complex and Cleavage furrow ingression, therefore connecting diverse disciplines of study.
He works mostly in the field of Protein kinase A, limiting it down to topics relating to Molecular biology and, in certain cases, ROCK1, Serine/threonine-specific protein kinase and Kinase, as a part of the same area of interest. His study with MDia1 involves better knowledge in Actin cytoskeleton. The concepts of his Actin study are interwoven with issues in DAAM1, Formins and Mitosis.
The scientist’s investigation covers issues in Cell biology, MDia1, Actin, Molecular biology and Actin cytoskeleton. His study in the field of Rho-associated protein kinase, Focal adhesion and Small GTPase is also linked to topics like Cleavage furrow. His research in Rho-associated protein kinase tackles topics such as Protein kinase A which are related to areas like Binding site.
His work carried out in the field of MDia1 brings together such families of science as Formins, Muscle hypertrophy, Cell migration and Actin remodeling. His Molecular biology research is multidisciplinary, incorporating elements of Kinase, Pleckstrin homology domain and Serine/threonine-specific protein kinase. His Actin cytoskeleton research includes elements of Stress fiber and Cell polarity.
Toshimasa Ishizaki focuses on Cell biology, Endocytosis, MDia1, Insulin and Exocytosis. Cell biology connects with themes related to Paracrine Communication in his study. His Endocytosis research is multidisciplinary, incorporating perspectives in GTPase-activating protein, Pancreatic beta Cells and Gene knockdown.
His MDia1 study deals with Heart failure intersecting with Signal transduction, Mechanotransduction and Actin cytoskeleton. In his research, Guanosine triphosphate, Guanosine diphosphate and Rab is intimately related to Endocytic cycle, which falls under the overarching field of Exocytosis. His work on Protein kinase A as part of general Phosphorylation research is often related to ZAP70, thus linking different fields of science.
Toshimasa Ishizaki spends much of his time researching Cell biology, GTPase, GTP', Small GTPase and Rab. His specific area of interest is Cell biology, where Toshimasa Ishizaki studies Cell signaling. The GTPase study combines topics in areas such as Guanosine diphosphate, Guanosine triphosphate, Guanosine and Effector.
Many of his studies involve connections with topics such as Endocytic cycle and Guanosine. His Endocytic cycle study combines topics in areas such as Secretion, PI3K/AKT/mTOR pathway, Crosstalk and Clathrin. His research combines IQGAP1 and GTP'.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
Masayoshi Uehata;Toshimasa Ishizaki;Hiroyuki Satoh;Takashi Ono.
Focal Contacts as Mechanosensors Externally Applied Local Mechanical Force Induces Growth of Focal Contacts by an Mdia1-Dependent and Rock-Independent Mechanism
Daniel Riveline;Daniel Riveline;Eli Zamir;Nathalie Q. Balaban;Ulrich S. Schwarz.
Journal of Cell Biology (2001)
Cooperation between mDia1 and ROCK in Rho-induced actin reorganization
Naoki Watanabe;Takayuki Kato;Akiko Fujita;Toshimasa Ishizaki.
Nature Cell Biology (1999)
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
Toshimasa Ishizaki;Midori Maekawa;Kazuko Fujisawa;Katsuya Okawa.
The EMBO Journal (1996)
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin.
Naoki Watanabe;Pascal Madaule;Tim Reid;Toshimasa Ishizaki.
The EMBO Journal (1997)
ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice
Osamu Nakagawa;Kazuko Fujisawa;Toshimasa Ishizaki;Yuji Saito.
FEBS Letters (1996)
Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion.
Shuh Narumiya;Masahiro Tanji;Toshimasa Ishizaki.
Cancer and Metastasis Reviews (2009)
p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions
Toshimasa Ishizaki;Mamoru Naito;Kazuko Fujisawa;Midori Maekawa.
FEBS Letters (1997)
Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho
Go Watanabe;Yuji Saito;Pascal Madaule;Toshimasa Ishizaki.
Molecular Dissection of the Rho-associated Protein Kinase (p160ROCK)-regulated Neurite Remodeling in Neuroblastoma N1E-115 Cells
Masaya Hirose;Toshimasa Ishizaki;Naoki Watanabe;Masayoshi Uehata.
Journal of Cell Biology (1998)
If you think any of the details on this page are incorrect, let us know.
We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below: