World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
119
Citations
58174
World Ranking
3859
National Ranking
2110

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

James K. Liao is affiliated with the University of Chicago in the United States. Their research spans several areas within medicine and biochemistry, genetics, and molecular biology, with a particular focus on cardiovascular health and neurological diseases.

The main fields of study undertaken by James K. Liao include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Their research covers multiple subfields, such as:

  • Neurology
  • Cardiology and Cardiovascular Medicine
  • Molecular Biology
  • Cancer Research
  • Genetics

James K. Liao's work addresses a variety of scientific topics, including:

  • Cancer, Hypoxia, and Metabolism
  • Nitric Oxide and Endothelin Effects
  • Lipoproteins and Cardiovascular Health
  • Barrier Structure and Function Studies
  • Neurological Disease Mechanisms and Treatments
  • Protein Kinase Regulation and GTPase Signaling
  • Intracerebral and Subarachnoid Hemorrhage Research

The scientist has published several recent papers, notable among them are:

  • "Understanding the molecular mechanisms of statin pleiotropic effects" (2023) in Archives of Toxicology
  • "Emerging views of statin pleiotropy and cholesterol lowering" (2021) in Cardiovascular Research
  • "Increase in Blood-Brain Barrier (BBB) Permeability Is Regulated by MMP3 via the ERK Signaling Pathway" (2021) in Oxidative Medicine and Cellular Longevity
  • "Targeting Rho-associated coiled-coil forming protein kinase (ROCK) in cardiovascular fibrosis and stiffening" (2020) in Expert Opinion on Therapeutic Targets
  • "Serine-threonine kinase ROCK2 regulates germinal center B cell positioning and cholesterol biosynthesis" (2020) in Journal of Clinical Investigation

Frequent publication venues include:

  • Circulation Research
  • Cardiovascular Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of the American Heart Association
  • Circulation

James K. Liao often collaborates with several co-authors, among whom are:

  • Rongxue Wu
  • Albert Sitikov
  • Nikola Sladojević
  • Lizhuo Ai
  • Kaichao Pan

In recognition of their professional contributions, James K. Liao holds membership in the Association of American Physicians.

Best Publications

  • Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors

    U. Laufs;V. La Fata;J. Plutzky;J. K. Liao

  • PLEIOTROPIC EFFECTS OF STATINS

    James K. Liao;Ulrich Laufs

  • Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.

    R De Caterina;Peter Libby;H B Peng;V J Thannickal

  • Pleiotropic Effects of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors

    Masao Takemoto;James K. Liao

  • Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

    Tommaso Simoncini;Ali Hafezi-Moghadam;Derek P. Brazil;Klaus Ley

  • Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase

    Ulrich Laufs;James K. Liao

  • Anti-inflammatory Properties of Cytochrome P450 Epoxygenase-Derived Eicosanoids

    Koichi Node;Yuqing Huo;Xiulu Ruan;Baichun Yang

  • Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase

    Matthias Endres;Ulrich Laufs;Zhihong Huang;Tadashi Nakamura

  • Pleiotropic Effects of Statins on the Cardiovascular System.

    Adam Oesterle;Ulrich Laufs;James K. Liao

  • Induction and Stabilization of IκBα by Nitric Oxide Mediates Inhibition of NF-κB

    Hai-Bing Peng;Peter Libby;James K. Liao

  • OXIDIZED LOW-DENSITY LIPOPROTEIN DECREASES THE EXPRESSION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE

    James K. Liao;Wee Soo Shin;Wen Yee Lee;Stephen L. Clark

  • Pleiotropic effects of statin therapy: molecular mechanisms and clinical results

    Chao Yung Wang;Ping Yen Liu;James K. Liao

  • Pleiotropic effects of statins. - Basic research and clinical perspectives -.

    Qian Zhou;James K. Liao

  • Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy

    Masao Takemoto;Koichi Node;Hironori Nakagami;Yulin Liao

  • Fatty acid modulation of endothelial activation

    R. De Caterina;J. K. Liao;P. Libby

  • Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase.

    Ali Hafezi-Moghadam;Tommaso Simoncini;Zequan Yang;Florian P. Limbourg

  • Rho GTPases, Statins, and Nitric Oxide

    Yoshiyuki Rikitake;James K. Liao

  • Isoprenoids as mediators of the biological effects of statins

    James K. Liao

  • Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy.

    Koichi Node;Masashi Fujita;Masafumi Kitakaze;Masatsugu Hori

  • Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase (cerebral blood f lowycerebral ischemia)

    Matthias Endres;U Lrich Laufs;Z Hihong Huang;Tadashi Nakamura

Frequent Co-Authors

Michael A. Moskowitz
Michael A. Moskowitz Harvard University
Ulrich Laufs
Ulrich Laufs Saarland University
Yukihito Higashi
Yukihito Higashi Hiroshima University
Kazuaki Chayama
Kazuaki Chayama Hiroshima University
Darryl C. Zeldin
Darryl C. Zeldin National Institutes of Health
Peter Libby
Peter Libby Brigham and Women's Hospital
Mark A. Creager
Mark A. Creager Dartmouth College
Paul L. Huang
Paul L. Huang Harvard University
Issam A. Awad
Issam A. Awad University of Chicago
Matthias Endres
Matthias Endres Charité - University Medicine Berlin

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