2019 - Fellow, National Academy of Inventors
Member of the Association of American Physicians
John P. Cooke spends much of his time researching Internal medicine, Endocrinology, Nitric oxide, Endothelium and Vasodilation. As part of his studies on Internal medicine, John P. Cooke often connects relevant subjects like Asymmetric dimethylarginine. His research in Endocrinology intersects with topics in Platelet and Antagonist.
The Nitric oxide study combines topics in areas such as Cell culture, Arginine, Pharmacology and Biochemistry. John P. Cooke combines subjects such as Endothelial stem cell, Angiogenesis, Biophysics and Immunology, Monocyte with his study of Endothelium. His work carried out in the field of Vasodilation brings together such families of science as Artery, Methacholine, Anatomy, Forearm and Vascular disease.
His primary areas of investigation include Internal medicine, Endocrinology, Nitric oxide, Endothelium and Cell biology. His Internal medicine research is multidisciplinary, relying on both Asymmetric dimethylarginine and Cardiology. His Nitric oxide research includes elements of Arginine, Pharmacology and Endogeny, Biochemistry.
Endothelium is often connected to Monocyte in his work. His Cell biology study combines topics in areas such as Endothelial stem cell, Reprogramming, Immunology, Induced pluripotent stem cell and Innate immune system. In his study, Nicotine, Vascular endothelial growth factor and Pathology is inextricably linked to Angiogenesis, which falls within the broad field of Endothelial stem cell.
His primary areas of investigation include Cell biology, Internal medicine, Cardiology, Cancer research and Angiogenesis. John P. Cooke has included themes like Endothelial stem cell, Innate immune system, Transcription factor and Induced pluripotent stem cell in his Cell biology study. John P. Cooke has researched Innate immune system in several fields, including Epigenetics, Nitric oxide and Somatic cell.
John P. Cooke interconnects Chromatin and Endothelium in the investigation of issues within Transcription factor. His Internal medicine research includes themes of Asymmetric dimethylarginine, Endocrinology and Mesenchymal stem cell. His biological study spans a wide range of topics, including Paracrine signalling, LMO2, Immunology and Pathology.
His primary areas of study are Cell biology, Inflammation, Cancer research, Angiogenesis and Pathology. His studies deal with areas such as Chromatin, Innate immune system, Transcription factor and Endothelium as well as Cell biology. His studies in Endothelium integrate themes in fields like Regeneration and Immunity.
The study incorporates disciplines such as Vascular endothelial growth factor C and Paracrine signalling in addition to Pathology. His work in the fields of Nitric oxide synthase and Nitrosylation overlaps with other areas such as S-Nitrosylation. John P. Cooke integrates many fields in his works, including Internal medicine and GERD.
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Asymmetric Dimethylarginine (ADMA): A Novel Risk Factor for Endothelial Dysfunction Its Role in Hypercholesterolemia
Rainer H. Böger;Stefanie M. Bode-Böger;Andrzej Szuba;Philip S. Tsao.
Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.
Mark A. Creager;John P. Cooke;Michael E. Mendelsohn;Shelly J. Gallagher.
Journal of Clinical Investigation (1990)
Endogenous Nitric Oxide Synthase Inhibitor A Novel Marker of Atherosclerosis
Hiroshi Miyazaki;Hidehiro Matsuoka;John P. Cooke;Michiaki Usui.
L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.
Mark A. Creager;Shelly J. Gallagher;Xavier J. Girerd;Sharon M. Coleman.
Journal of Clinical Investigation (1992)
Gene therapy inhibiting neointimal vascular lesion: In vivo transfer of endothelial cell nitric oxide synthase gene
H. E. Von Der Leyen;G. H. Gibbons;R. Morishita;N. P. Lewis.
Proceedings of the National Academy of Sciences of the United States of America (1995)
Nitric oxide synthase: role in the genesis of vascular disease.
John P. Cooke;Victor J. Dzau.
Annual Review of Medicine (1997)
Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis
Christopher Heeschen;James J. Jang;Michael Weis;Anjali Pathak.
Nature Medicine (2001)
Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit.
John P. Cooke;Alan H. Singer;Philip Tsao;Pauline Zera.
Journal of Clinical Investigation (1992)
Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase.
Akira Ito;Philip S. Tsao;Shanthi Adimoolam;Masumi Kimoto.
Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase.
Ken Y. Lin;Akira Ito;Tomoko Asagami;Philip S. Tsao.
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