World's Best Scientists 2026 revealed!

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Medicine

D-Index
132
Citations
60003
World Ranking
2327
National Ranking
1315

Research.com Recognitions

  • 2019 - Fellow, National Academy of Inventors
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

John P. Cooke is affiliated with Houston Methodist in the United States and has an extensive body of research primarily focused on biochemistry, genetics, molecular biology, and medicine. Their work spans various subfields including molecular biology, surgery, cardiology and cardiovascular medicine, physiology, and immunology.

The scientist's recent papers reflect interests in vascular biology, RNA therapeutics, and nanotechnology. Notable publications include:

  • "The Limitless Future of RNA Therapeutics" (2021) published in Frontiers in Bioengineering and Biotechnology
  • "New Directions in Therapeutic Angiogenesis and Arteriogenesis in Peripheral Arterial Disease" (2021) published in Circulation Research
  • "Vascular Regeneration in Peripheral Artery Disease" (2020) published in Arteriosclerosis Thrombosis and Vascular Biology
  • "Nanobiosensing with graphene and carbon quantum dots: Recent advances" (2020) published in Materials Today
  • "A relay velocity model infers cell-dependent RNA velocity" (2023) published in Nature Biotechnology

John P. Cooke has frequently published in venues such as Circulation, Heart Lung and Circulation, Frontiers in Cardiovascular Medicine, Nature Communications, and bioRxiv (Cold Spring Harbor Laboratory).

Their main topics of research cover a diverse range including:

  • RNA Interference and Gene Delivery
  • Telomeres, Telomerase, and Senescence
  • Angiogenesis and VEGF in Cancer
  • Nuclear Structure and Function
  • Single-cell and spatial transcriptomics
  • COVID-19 Clinical Research Studies
  • CRISPR and Genetic Engineering

Prominent frequent collaborators in their research include Guangyu Wang, Jun-ichi Abe, Anahita Mojiri, Sivareddy Kotla, and Kaifu Chen.

John P. Cooke has been recognized as a Fellow of the National Academy of Inventors in 2019 and is a member of the Association of American Physicians.

Best Publications

  • Asymmetric Dimethylarginine (ADMA): A Novel Risk Factor for Endothelial Dysfunction Its Role in Hypercholesterolemia

    Rainer H. Böger;Stefanie M. Bode-Böger;Andrzej Szuba;Philip S. Tsao

  • Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.

    Mark A. Creager;John P. Cooke;Michael E. Mendelsohn;Shelly J. Gallagher

  • Endogenous Nitric Oxide Synthase Inhibitor A Novel Marker of Atherosclerosis

    Hiroshi Miyazaki;Hidehiro Matsuoka;John P. Cooke;Michiaki Usui

  • L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.

    Mark A. Creager;Shelly J. Gallagher;Xavier J. Girerd;Sharon M. Coleman

  • Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis

    Christopher Heeschen;James J. Jang;Michael Weis;Anjali Pathak

  • Gene therapy inhibiting neointimal vascular lesion: In vivo transfer of endothelial cell nitric oxide synthase gene

    H. E. Von Der Leyen;G. H. Gibbons;R. Morishita;N. P. Lewis

  • Nitric oxide synthase: role in the genesis of vascular disease.

    John P. Cooke;Victor J. Dzau

  • Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase.

    Ken Y. Lin;Akira Ito;Tomoko Asagami;Philip S. Tsao

  • Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase.

    Akira Ito;Philip S. Tsao;Shanthi Adimoolam;Masumi Kimoto

  • Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit.

    John P. Cooke;Alan H. Singer;Philip Tsao;Pauline Zera

  • Statins Have Biphasic Effects on Angiogenesis

    Michael Weis;Christopher Heeschen;Alec J. Glassford;John P. Cooke

  • Homocysteine Impairs the Nitric Oxide Synthase Pathway Role of Asymmetric Dimethylarginine

    Markus C. Stühlinger;Philip S. Tsao;Jeng Horng Her;Masumi Kimoto

  • Does ADMA cause endothelial dysfunction

    John P. Cooke

  • Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor.

    Markus C. Stühlinger;Fahim Abbasi;James W. Chu;Cindy Lamendola

  • Multifunctional in vivo vascular imaging using near-infrared II fluorescence

    Guosong Hong;Jerry C Lee;Joshua T Robinson;Uwe Raaz

  • Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator.

    John P. Cooke;Eugene Rossitch;Nancy A. Andon;Joseph Loscalzo

  • Cardiovascular effects of exercise: Role of endothelial shear stress

    Josef Niebauer;John P. Cooke

  • Expression of Inducible Nitric Oxide Synthase in Human Heart Failure

    Guy A. Haywood;Philip S. Tsao;Heiko E. von der Leyen;Michael J. Mann

  • Asymmetrical dimethylarginine: the Uber marker?

    John P. Cooke

  • Phytoestrogens and cardiovascular health

    Lynette Wroblewski Lissin;John P Cooke

Frequent Co-Authors

Philip S. Tsao
Philip S. Tsao Stanford University
Ngan F. Huang
Ngan F. Huang Cardiovascular Institute of the South
Victor J. Dzau
Victor J. Dzau Duke University
Christopher Heeschen
Christopher Heeschen Shanghai Jiao Tong University
Jeffrey W. Olin
Jeffrey W. Olin Icahn School of Medicine at Mount Sinai
Edward S. Mocarski
Edward S. Mocarski Emory University
Wing-Tak Wong
Wing-Tak Wong Hong Kong Polytechnic University
Alan C. Yeung
Alan C. Yeung Stanford University
Mark A. Creager
Mark A. Creager Dartmouth College
William F. Fearon
William F. Fearon Stanford University

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