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Biology and Biochemistry

D-Index
112
Citations
57522
World Ranking
882
National Ranking
550

Overview

Keith Burridge is affiliated with the University of North Carolina at Chapel Hill in the United States. Their work primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with a significant focus on Medicine. Within these broad areas, their research is particularly concentrated in the subfields of Molecular Biology, Cell Biology, and Immunology and Allergy, along with contributions to Genetics and Cardiology and Cardiovascular Medicine.

The main topics addressed by Keith Burridge include cellular mechanics and interactions, cell adhesion molecules research, cardiomyopathy and myosin studies, microtubule and mitosis dynamics, angiogenesis and VEGF in cancer, protein kinase regulation and GTPase signaling, and connective tissue disorders research. These topics illustrate the breadth of their scientific inquiry into cellular and molecular processes linked to both fundamental biology and disease mechanisms.

Burridge has been involved in multiple publications, with frequent venue contributions such as:

  • UNC Libraries
  • Cell Communication and Signaling
  • Author eBooks

Some recent papers include:

  • Integrin-mediated cell adhesion activates mitogen-activated protein kinases, 2021, UNC Libraries
  • Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells, 2020, Cell Communication and Signaling
  • Rho-mediated Contractility Exposes a Cryptic Site in Fibronectin and Induces Fibronectin Matrix Assembly, 2020, UNC Libraries
  • RhoA Inactivation by p190RhoGAP Regulates Cell Spreading and Migration by Promoting Membrane Protrusion and Polarity, 2020, UNC Libraries
  • Vav2 Is an Activator of Cdc42, Rac1, and RhoA, 2021, UNC Libraries

Their frequent co-authors include Christophe Guilluy, Rafael García-Mata, Richard Superfine, Erika S. Wittchen, and Elizabeth Monaghan-Benson. These collaborations indicate a network of researchers working within similar or complementary areas of cellular and molecular biology.

Best Publications

  • Cell migration: integrating signals from front to back.

    Anne J. Ridley;Martin A. Schwartz;Keith Burridge;Richard A. Firtel

  • Focal adhesions: Transmembrane junctions between the extracellular matrix and the cytoskeleton

    Keith Burridge;Karl Fath;Thomas Kelly;Glen Nuckolls

  • Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

    Keith Burridge;Christopher E. Turner;Lewis H. Romer

  • Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

    Alan Horwitz;Kimberly Duggan;Clayton Buck;Mary C. Beckerle

  • An interaction between alpha-actinin and the beta 1 integrin subunit in vitro.

    Carol A. Otey;Fredrick M. Pavalko;Keith Burridge

  • Bidirectional signaling between the cytoskeleton and integrins.

    Simone M Schoenwaelder;Keith Burridge

  • Paxillin: a new vinculin-binding protein present in focal adhesions.

    Christopher E. Turner;John R. Glenney;Keith Burridge

  • INTEGRIN-MEDIATED CELL ADHESION ACTIVATES MITOGEN-ACTIVATED PROTEIN KINASES

    Qiming Chen;Michael S. Kinch;Tsung H. Lin;Keith Burridge

  • The 'invisible hand': regulation of RHO GTPases by RHOGDIs.

    Rafael Garcia-Mata;Etienne Boulter;Keith Burridge

  • Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts

    Clare M. Waterman-Storer;Rebecca A. Worthylake;Betty P. Liu;Keith Burridge

  • Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus.

    Christophe Guilluy;Lukas D. Osborne;Laurianne Van Landeghem;Lisa Sharek

  • An interaction between vinculin and talin.

    Keith W T Burridge;Paul Mangeat

  • Cadherin engagement regulates Rho family GTPases.

    Nicole K. Noren;Carien M. Niessen;Barry M. Gumbiner;Keith W T Burridge

  • Microinjection and localization of a 130K protein in living fibroblasts: a relationship to actin and fibronectin

    Keith Burridge;James R. Feramisco

  • Recruitment of the Arp2/3 complex to vinculin: Coupling membrane protrusion to matrix adhesion

    Kris A. DeMali;Christy A. Barlow;Keith Burridge

  • ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration

    Michael J. Allingham;Jaap D. van Buul;Keith Burridge

  • The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

    Christophe Guilluy;Vinay Swaminathan;Rafael Garcia-Mata;E. Timothy O’Brien

  • Focal adhesions, stress fibers and mechanical tension.

    Keith Burridge;Christophe Guilluy

  • RhoA and ROCK Promote Migration by Limiting Membrane Protrusions

    Rebecca A. Worthylake;Keith Burridge

  • The 180-kD component of the neural cell adhesion molecule N-CAM is involved in cell-cell contacts and cytoskeleton-membrane interactions.

    G. Elisabeth Pollerberg;Keith Burridge;Keith E. Krebs;Steven R. Goodman

Frequent Co-Authors

Carol A. Otey
Carol A. Otey University of North Carolina at Chapel Hill
Christopher E. Turner
Christopher E. Turner SUNY Upstate Medical University
Channing J. Der
Channing J. Der University of North Carolina at Chapel Hill
Sharon L. Campbell
Sharon L. Campbell University of North Carolina at Chapel Hill
Michael S. Kinch
Michael S. Kinch Washington University in St. Louis
Andrew F. G. Quest
Andrew F. G. Quest University of Chile
Pascal Schneider
Pascal Schneider University of Lausanne
Mary C. Beckerle
Mary C. Beckerle University of Utah
Scott H. Randell
Scott H. Randell University of North Carolina at Chapel Hill
James R. Feramisco
James R. Feramisco University of California, San Diego

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