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Akira Kakizuka

Akira Kakizuka

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
26687
World Ranking
8453
National Ranking
564

Overview

Akira Kakizuka is affiliated with Kyoto University in Japan and has contributed extensively to research in Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Molecular Biology, Cell Biology, Ophthalmology, Cellular and Molecular Neuroscience, and Immunology.

Their research covers multiple scientific topics, with significant focus on:

  • Endoplasmic Reticulum Stress and Disease
  • Phagocytosis and Immune Regulation
  • Retinal Development and Disorders
  • Genetic Neurodegenerative Diseases
  • Osteoarthritis Treatment and Mechanisms
  • Glaucoma and retinal disorders
  • Adenosine and Purinergic Signaling

Kakizuka has published in a variety of journals, frequently contributing to:

  • Scientific Reports
  • PLoS ONE
  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Genes to Cells

Notable recent papers include:

  • "Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis," 2020, eLife
  • "Safety and effectiveness of a novel neuroprotectant, KUS121, in patients with non-arteritic central retinal artery occlusion: An open-label, non-randomized, first-in-humans, phase 1/2 trial," 2020, PLoS ONE
  • "VCP relocalization limits mitochondrial activity, GSH depletion and ferroptosis during starvation in PC3 prostate cancer cells," 2021, Genes to Cells
  • "Genetic screening for potassium channel mutations in Japanese autosomal dominant spinocerebellar ataxia," 2020, Journal of Human Genetics
  • "Survival and process outgrowth of human iPSC-derived cells expressing Purkinje cell markers in a mouse model for spinocerebellar degenerative disease," 2023, Experimental Neurology

Kakizuka collaborates frequently with other researchers, including:

  • Hanako Ohashi Ikeda
  • Sachiko Iwai
  • Akitaka Tsujikawa
  • Kohei Nishitani
  • Motoo Saito

Best Publications

  • CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

    Yoshiya Kawaguchi;Toshihiro Okamoto;Masafumi Taniwaki;Megumi Aizawa

  • Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

    A. Kakizuka;W.H. Miller;K. Umesono;K. Umesono;R.P. Warrell

  • ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

    Hideki Nishitoh;Atsushi Matsuzawa;Kei Tobiume;Kaoru Saegusa

  • Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

    D J Mangelsdorf;U Borgmeyer;R A Heyman;J Y Zhou;J Y Zhou

  • The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

    Toshimasa Ishizaki;Midori Maekawa;Kazuko Fujisawa;Katsuya Okawa

  • p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin.

    Naoki Watanabe;Pascal Madaule;Tim Reid;Toshimasa Ishizaki

  • A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

    Jacqueline A. Dyck;Jacqueline A. Dyck;Gerd G. Maul;Wilson H. Miller;J.Don Chen

  • Expanded polyglutamine in the machado-joseph disease protein induces cell death in vitro and in vivo

    Hanako Ikeda;Masahiro Yamaguchi;Satoshi Sugai;Yoshiya Aze

  • Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity.

    Tsunehisa Namba;Yukihiko Sugimoto;Manabu Negishi;Atsushi Irie

  • Caspase Cleavage of Gene Products Associated with Triplet Expansion Disorders Generates Truncated Fragments Containing the Polyglutamine Tract

    Cheryl L. Wellington;Lisa M. Ellerby;Abigail S. Hackam;Russell L. Margolis

  • Molecular characterization of a functional cDNA for rat substance P receptor.

    Y Yokota;Y Sasai;K Tanaka;T Fujiwara

  • Protein Kinase N (PKN) and PKN-Related Protein Rhophilin as Targets of Small GTPase Rho

    Go Watanabe;Yuji Saito;Pascal Madaule;Toshimasa Ishizaki

  • Listeria monocytogenes ActA-mediated escape from autophagic recognition

    Yuko Yoshikawa;Michinaga Ogawa;Torsten Hain;Mitsutaka Yoshida

  • PPARγ coactivator 1β/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity

    Yasutomi Kamei;Hiroshi Ohizumi;Yasushi Fujitani;Tomoyuki Nemoto

  • Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation.

    T Hirata;F Ushikubi;A Kakizuka;M Okuma

  • Diversity in ATP concentrations in a single bacterial cell population revealed by quantitative single-cell imaging

    Hideyuki Yaginuma;Shinnosuke Kawai;Kazuhito V. Tabata;Keisuke Tomiyama

  • Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor α clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia

    Wilson H. Miller;Akira Kakizuka;Stanley R. Frankel;Raymond P. Warrell

  • cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla.

    T Namba;H Oida;Y Sugimoto;A Kakizuka

  • IκBγ, a 70 kd protein identical to the C-terminal half of p110 NF-κB: A new member of the IκB family

    Jun-ichiro Inoue;Lawrence D. Kerr;Akira Kakizuka;Inder M. Verma

  • Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15.

    Byron Sebastian;Akira Kakizuka;Tony Hunter

Frequent Co-Authors

Shuh Narumiya
Shuh Narumiya Kyoto University
Nagahisa Yoshimura
Nagahisa Yoshimura Kyoto University
Ronald M. Evans
Ronald M. Evans Salk Institute for Biological Studies
Yukihiko Sugimoto
Yukihiko Sugimoto Kumamoto University
Mitinori Saitou
Mitinori Saitou Kyoto University
Wilson H. Miller
Wilson H. Miller McGill University
Toshimasa Ishizaki
Toshimasa Ishizaki Oita University
Atsushi Ichikawa
Atsushi Ichikawa Mukogawa Women's University
Keiji Tanaka
Keiji Tanaka Tokyo Metropolitan Institute of Medical Science
Gen Sobue
Gen Sobue Aichi Medical University

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