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D-Index & Metrics

Biology and Biochemistry

D-Index
67
Citations
16853
World Ranking
8181
National Ranking
3698

Overview

John Sondek is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research is primarily situated within the fields of Biochemistry, Genetics, and Molecular Biology, with a focus on various subfields including Molecular Biology, Cell Biology, Physiology, Immunology, and Genetics. Their work addresses several key scientific topics:

  • Protein Kinase Regulation and GTPase Signaling
  • Alzheimer's disease research and treatments
  • Mitochondrial Function and Pathology
  • Amino Acid Enzymes and Metabolism
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Cell Adhesion Molecules Research
  • Cellular transport and secretion

The scientist has published extensively, with 87 publications in related fields, predominantly through UNC Libraries. Other frequent venues include bioRxiv (Cold Spring Harbor Laboratory), OPAL (Open@LaTrobe) at La Trobe University, Journal of Biological Chemistry, and Immunity.

Recent publications by John Sondek include:

  • Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease, 2023, Immunity
  • Multiplexed GTPase and GEF biosensor imaging enables network connectivity analysis, 2020, Nature Chemical Biology
  • Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes, 2022, eLife
  • A High-Throughput Assay to Identify Allosteric Inhibitors of the PLC-γ Isozymes Operating at Membranes, 2020, Biochemistry
  • Designer proteins that competitively inhibit Gαq by targeting its effector site, 2021, Journal of Biological Chemistry

Frequent collaborators in John Sondek's work include Nicole Hajicek, T. Kendall Harden, Qisheng Zhang, Kent L. Rossman, and Edhriz Siraliev-Perez. These coauthor relationships reflect sustained research partnerships contributing to the scientific output.

Best Publications

  • GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

    Kent L. Rossman;Channing J. Der;John Sondek

  • The 2.0 Å crystal structure of a heterotrimeric G protein

    David G. Lambright;John Sondek;Andrew Bohm;Nikolai P. Skiba

  • Crystal structure of a G-protein beta gamma dimer at 2.1A resolution

    John Sondek;Andrew Bohm;David G. Lambright;David G. Lambright;Heidi E. Hamm

  • GTPase Mechanism of Gproteins From the 1.7-A Crystal Structure of Transducin alpha-GDP-AIF-4

    John Sondek;David G. Lambright;Joseph P. Noel;Heidi E. Hamm;Heidi E. Hamm

  • Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.

    David K. Worthylake;Kent L. Rossman;John Sondek

  • Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

    John M. Lambert;Que T. Lambert;Gary W. Reuther;Angeliki Malliri

  • The experimental power of FR900359 to study Gq-regulated biological processes

    Ramona Schrage;Anna Lena Schmitz;Evelyn Gaffal;Suvi Annala

  • The Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target, RIN4, from Arabidopsis membranes to block RPM1 activation

    Han Suk Kim;Darrell Desveaux;Alex U. Singer;Priyesh Patel

  • A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.

    Kent L. Rossman;David K. Worthylake;Jason T. Snyder;David P. Siderovski

  • Structural determinants for GoLoco-induced inhibition of nucleotide release by Gα subunits

    Randall J. Kimple;Michelle E. Kimple;Laurie Betts;John E Sondek

  • STRUCTURAL BASIS FOR THE SELECTIVE ACTIVATION OF RHO GTPASES BY DBL EXCHANGE FACTORS

    Jason T Snyder;David K Worthylake;Kent L Rossman;Laurie Betts

  • Kinetic Scaffolding Mediated by a Phospholipase C–β and Gq Signaling Complex

    Gary L. Waldo;Tiffany K. Ricks;Stephanie N. Hicks;Matthew L. Cheever

  • Overview of Affinity Tags for Protein Purification

    Michelle E. Kimple;John Sondek

  • Phagocytosis of Apoptotic Cells Is Regulated by a UNC-73/TRIO-MIG-2/RhoG Signaling Module and Armadillo Repeats of CED-12/ELMO

    Colin D. DeBakker;Lisa B. Haney;Jason M. Kinchen;Cynthia Grimsley

  • The phospholipase C isozymes and their regulation.

    Aurelie Gresset;John Sondek;T. Kendall Harden

  • General and Versatile Autoinhibition of PLC Isozymes

    Stephanie N. Hicks;Mark R. Jezyk;Svetlana Gershburg;Jason P. Seifert

  • Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation

    Anurag Singh;Antoine E Karnoub;Todd R Palmby;Ernst Lengyel

  • Tuba, a Novel Protein Containing Bin/Amphiphysin/Rvs and Dbl Homology Domains, Links Dynamin to Regulation of the Actin Cytoskeleton

    Marco A. Salazar;Adam V. Kwiatkowski;Lorenzo Pellegrini;Gianluca Cestra

  • REGULATION OF PHOSPHOLIPASE C ISOZYMES BY RAS SUPERFAMILY GTPASES

    T. Kendall Harden;John E Sondek

  • Ggamma-like (GGL) domains: new frontiers in G-protein signaling and beta-propeller scaffolding.

    John Sondek;David P. Siderovski

Frequent Co-Authors

T. Kendall Harden
T. Kendall Harden University of North Carolina at Chapel Hill
David P. Siderovski
David P. Siderovski West Virginia University
Channing J. Der
Channing J. Der University of North Carolina at Chapel Hill
David R Shortle
David R Shortle Johns Hopkins University School of Medicine
Jeffery L. Dangl
Jeffery L. Dangl University of North Carolina at Chapel Hill
David G. Lambright
David G. Lambright University of Massachusetts Chan Medical School
Heidi E. Hamm
Heidi E. Hamm Vanderbilt University
Klaus M. Hahn
Klaus M. Hahn University of North Carolina at Chapel Hill
Gaudenz Danuser
Gaudenz Danuser The University of Texas Southwestern Medical Center
Darrell Desveaux
Darrell Desveaux University of Toronto

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