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Chemistry

D-Index
57
Citations
11594
World Ranking
11083
National Ranking
3028

Overview

David R Shortle is affiliated with Johns Hopkins University School of Medicine in the United States. Their research contributions include work published in the field of protein structure assessment and quality. The most recent publication by Shortle is titled Highlights of Model Quality Assessment in CASP16. This paper was published in 2025 in the venue PubMed.

Shortle has collaborated with multiple co-authors across their recent work. Frequent collaborators include:

  • Alisia Fadini
  • Recep Adiyaman
  • Shaima N Alhaddad
  • Bijan Behzadi
  • Jianlin Cheng

Their work has appeared in the following publication venues:

  • PubMed

Their research outputs contribute to the broader scientific understanding within the area of model quality assessment, particularly in protein structure prediction contexts presented at CASP events.

Best Publications

  • Denatured States of Proteins

    Ken A. Dill;David Shortle

  • Persistence of Native-Like Topology in a Denatured Protein in 8 M Urea

    David Shortle;Michael S. Ackerman

  • The denatured state (the other half of the folding equation) and its role in protein stability.

    David Shortle

  • Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease

    David Shortle;Wesley E. Stites;Alan K. Meeker

  • Characterization of long-range structure in the denatured state of staphylococcal nuclease. I. Paramagnetic relaxation enhancement by nitroxide spin labels.

    Joel R. Gillespie;David Shortle

  • Characterization of long-range structure in the denatured state of staphylococcal nuclease. II. Distance restraints from paramagnetic relaxation and calculation of an ensemble of structures.

    Joel R. Gillespie;David Shortle

  • Mutant forms of staphylococcal nuclease with altered patterns of guanidine hydrochloride and urea denaturation.

    David Shortle;Alan K. Meeker

  • Residual structure in large fragments of staphylococcal nuclease: effects of amino acid substitutions.

    David Shortle;Alan K. Meeker

  • Structural analysis of non-native states of proteins by NMR methods.

    David R Shortle

  • Truncated staphylococcal nuclease is compact but disordered.

    John M. Flanagan;Mikio Kataoka;David Shortle;Donald M. Engelman

  • Structure and Dynamics of a Denatured 131-Residue Fragment of Staphylococcal Nuclease: A Heteronuclear NMR Study

    Andrei T. Alexandrescu;Chitrananda Abeygunawardana;David Shortle

  • Kinetic and magnetic resonance studies of active-site mutants of staphylococcal nuclease: factors contributing to catalysis.

    Engin H. Serpersu;David Shortle;Albert S. Mildvan

  • Stability mutants of staphylococcal nuclease: large compensating enthalpy-entropy changes for the reversible denaturation reaction.

    David Shortle;Alan K. Meeker;Ernesto Freire

  • Staphylococcal Nuclease: A Showcase of m-Value Effects

    David Shortle

  • Denatured states of proteins and their roles in folding and stability

    David Shortle

  • Probing the determinants of protein folding and stability with amino acid substitutions.

    D Shortle

  • Contributions of the polar, uncharged amino acids to the stability of staphylococcal nuclease: evidence for mutational effects on the free energy of the denatured state.

    Susan M. Green;Alan K. Meeker;David Shortle

  • Kinetic and magnetic resonance studies of effects of genetic substitution of a Ca2+-liganding amino acid in staphylococcal nuclease.

    Engin H. Serpersu;David Shortle;Albert S. Mildvan

  • Backbone dynamics of a highly disordered 131 residue fragment of staphylococcal nuclease.

    Andrei T. Alexandrescu;David Shortle

  • Kinetic and ultraviolet spectroscopic studies of active-site mutants of delta 5-3-ketosteroid isomerase.

    Athan Kuliopulos;Albert S. Mildvan;David Shortle;Paul Talalay

Frequent Co-Authors

Alan K. Meeker
Alan K. Meeker Johns Hopkins University School of Medicine
John Sondek
John Sondek University of North Carolina at Chapel Hill
Albert S. Mildvan
Albert S. Mildvan Johns Hopkins University
Daniel Nathans
Daniel Nathans Johns Hopkins University
Lewis E. Kay
Lewis E. Kay University of Toronto
Athan Kuliopulos
Athan Kuliopulos Tufts University
Julie D. Forman-Kay
Julie D. Forman-Kay University of Toronto
David Botstein
David Botstein Princeton University
David J. Weber
David J. Weber University of Maryland, Baltimore
M. Daniel Lane
M. Daniel Lane Johns Hopkins University School of Medicine

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