World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
115
Citations
50315
World Ranking
453
National Ranking
232

Molecular Biology

D-Index
115
Citations
50315
World Ranking
308
National Ranking
186

Overview

Lothar Hennighausen is affiliated with the National Institutes of Health in the United States. Their research spans multiple areas within medicine, biochemistry, genetics, molecular biology, immunology, and microbiology. The main fields of study include Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology, highlighting a multidisciplinary approach to health sciences.

The scientist's subfields of research cover Molecular Biology, Immunology, Infectious Diseases, Genetics, and Oncology, indicating broad expertise in fundamental biological processes as well as disease-focused studies.

Main topics of work include:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Cytokine Signaling Pathways and Interactions
  • RNA Research and Splicing
  • Immune Cell Function and Interaction
  • Genomics and Chromatin Dynamics
  • Interferon and Immune Responses

Recent published papers reflect Hennighausen's focus areas and contributions to the field. Notable works include:

  • "Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury," 2020, Nature Communications
  • "Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2," 2020, PLoS Genetics
  • "Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos," 2020, Communications Biology
  • "A central role for STAT5 in the transcriptional programing of T helper cell metabolism," 2022, Science Immunology
  • "Prior Vaccination Exceeds Prior Infection in Eliciting Innate and Humoral Immune Responses in Omicron Infected Outpatients," 2022, Frontiers in Immunology

Hennighausen frequently publishes in journals such as bioRxiv (Cold Spring Harbor Laboratory), Journal of the American Society of Nephrology, iScience, Scientific Reports, and Nature Communications.

Frequent co-authors include:

  • Hye-Kyung Lee
  • Priscilla A. Furth
  • Ludwig Knabl
  • Jakub Jankowski
  • Chengyu Liu

This profile reflects a research career focused on fundamental and applied biomedical research, with multiple studies addressing genetic and immunological mechanisms related to diseases and immune responses.

Best Publications

  • Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

    Arian Laurence;Cristina M. Tato;Todd S. Davidson;Yuka Kanno

  • Stat5a is mandatory for adult mammary gland development and lactogenesis.

    Xiuwen Liu;Gertraud W. Robinson;Kay Uwe Wagner;Lisa Garrett

  • Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.

    Jason S Stumhofer;Arian Laurence;Emma H Wilson;Elaine Huang

  • Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter

    P A Furth;L St Onge;H Böger;P Gruss

  • Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

    Xiaoling Xu;Kay Uwe Wagner;Denise Larson;Zoë Weaver

  • Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells.

    Zhi Chen;Arian Laurence;Yuka Kanno;Margit Pacher-Zavisin

  • Nonredundant roles for Stat5a/b in directly regulating Foxp3

    Zhengju Yao;Zhengju Yao;Yuka Kanno;Marc Kerenyi;Geoffrey Stephens

  • Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue

    Xiuwen Liu;Gertraud W. Robinson;Fabrice Gouilleux;Bernd Groner

  • Information networks in the mammary gland

    Lothar Hennighausen;Gertraud W. Robinson

  • Cre-mediated gene deletion in the mammary gland.

    Kay Uwe Wagner;Robert J. Wall;Luc St-Onge;Peter Gruss

  • Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation.

    Yongzhi Cui;Greg Riedlinger;Keiko Miyoshi;Wei Tang

  • The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting{

    Robert D Cardiff;Miriam R Anver;Barry A Gusterson;Lothar Hennighausen

  • Signaling pathways in mammary gland development.

    Lothar Hennighausen;Gertraud W. Robinson

  • Activation of PPAR γ and δ by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease

    Josep Bassaganya-Riera;Kathryn Reynolds;Susan Martino-Catt;Yongzhi Cui

  • Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in burkitt lymphoma

    Ulrich Siebenlist;Lothar Hennighausen;Jim Battey;Philip Leder

  • Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution

    Minglin Li;Xiuwen Liu;Gertraud Robinson;Ud Bar-Peled

  • Stat5a/b are essential for normal lymphoid development and differentiation

    Zhengju Yao;Yongzhi Cui;Wendy T. Watford;Jay H. Bream;Jay H. Bream

  • Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B

    Lothar Hennighausen;Gertraud W. Robinson

  • Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation

    Gertraud W. Robinson;Robert A. McKnight;Gilbert H. Smith;Lothar Hennighausen

  • Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice

    Robert A. McKnight;Avi Shamay;Lakshmanan Sankaran;Robert J. Wall

Frequent Co-Authors

Gertraud W. Robinson
Gertraud W. Robinson National Institutes of Health
John J. O'Shea
John J. O'Shea National Institutes of Health
Timm Schroeder
Timm Schroeder ETH Zurich
Richard Moriggl
Richard Moriggl University of Veterinary Medicine Vienna
Gilbert H. Smith
Gilbert H. Smith National Institutes of Health
Bernd Groner
Bernd Groner Goethe University Frankfurt
Peter Ghazal
Peter Ghazal Cardiff University
Anthony Wynshaw-Boris
Anthony Wynshaw-Boris Case Western Reserve University
Arian Laurence
Arian Laurence University of Oxford
Demin Wang
Demin Wang Medical College of Wisconsin

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring molecular biology can open doors to a variety of career pathways in science and health. Many students find that expanding their education with additional qualifications in counseling, psychology, or human services can make them more versatile in the job market.

For those interested in mental health or advisory roles, earning the cheapest online master's in counseling is a cost-effective way to boost your credentials. Similarly, online clinical psychology programs are available for students looking to understand the connection between biology and behavior.

If you are looking for program flexibility, consider exploring human services online degree programs. These can provide quick, practical routes to careers in community and social services, including roles that support research or healthcare teams.

Finally, if you're considering a high-impact career change, teachers and science graduates may benefit from learning about career change for teachers higher pay—including the path from teacher to speech-language pathologist, which bridges science, language, and education.

Best Scientists Citing Lothar Hennighausen

Trending Scientists