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Microbiology

D-Index
67
Citations
29033
World Ranking
2223
National Ranking
188

Overview

Arian Laurence is affiliated with the University of Oxford in the United Kingdom and has concentrated their research primarily in the fields of Medicine and Immunology and Microbiology. Their work spans various subfields, including Immunology, Oncology, Infectious Diseases, Genetics, and Hematology.

Their recent research outputs include publications in notable journals such as Science Immunology, Nature Immunology, The Journal of Experimental Medicine, Annals of the Rheumatic Diseases, and Nature Reviews Immunology. Some of the recent papers by Laurence include:

  • SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation, 2021, Science Immunology
  • Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells, 2021, Nature Immunology
  • Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome, 2020, The Journal of Experimental Medicine
  • Selectivity, efficacy and safety of JAKinibs: new evidence for a still evolving story, 2023, Annals of the Rheumatic Diseases
  • Protein kinases: drug targets for immunological disorders, 2023, Nature Reviews Immunology

The scholar's frequent publication venues include:

  • Journal of Clinical Immunology
  • The Journal of Experimental Medicine
  • Science Immunology
  • Nature Immunology
  • Annals of the Rheumatic Diseases

Laurence collaborates regularly with other researchers, with frequent co-authors being:

  • Behdad Afzali
  • Holm H. Uhlig
  • Yin-Huai Chen
  • Ben Carpenter
  • Tilo Freiwald

Their research touches on several major topics, including:

  • Immunodeficiency and Autoimmune Disorders
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • CAR-T cell therapy research
  • Chronic Lymphocytic Leukemia Research
  • COVID-19 Clinical Research Studies
  • Autoimmune and Inflammatory Disorders Research

Best Publications

  • Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

    Arian Laurence;Cristina M. Tato;Todd S. Davidson;Yuka Kanno

  • Generation of pathogenic T H 17 cells in the absence of TGF-β signalling

    Kamran Ghoreschi;Arian Laurence;Xiang-Ping Yang;Cristina M Tato

  • Impaired T H 17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

    Joshua D. Milner;Jason M. Brenchley;Jason M. Brenchley;Arian Laurence;Alexandra F. Freeman

  • The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention*

    John J. O'Shea;Daniella M. Schwartz;Alejandro V. Villarino;Massimo Gadina

  • The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

    Mandy J McGeachy;Yi Chen;Cristina M Tato;Arian Laurence

  • Janus kinases in immune cell signaling.

    Kamran Ghoreschi;Arian Laurence;John J. O’Shea

  • Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.

    Jason S Stumhofer;Arian Laurence;Emma H Wilson;Elaine Huang

  • An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist

    Ivona Aksentijevich;Seth L. Masters;Polly J. Ferguson;Paul Dancey

  • Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

    Jason S Stumhofer;Jonathan S Silver;Arian Laurence;Paige M Porrett

  • IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner.

    Lai Wei;Arian Laurence;Kevin M. Elias;Kevin M. Elias;John J. O'Shea

  • Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells.

    Zhi Chen;Arian Laurence;Yuka Kanno;Margit Pacher-Zavisin

  • Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.

    Lydia Durant;Wendy T. Watford;Haydeé L. Ramos;Arian Laurence

  • Nonredundant roles for Stat5a/b in directly regulating Foxp3

    Zhengju Yao;Zhengju Yao;Yuka Kanno;Marc Kerenyi;Geoffrey Stephens

  • Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5.

    Xiang Ping Yang;Kamran Ghoreschi;Scott M. Steward-Tharp;Jaime Rodriguez-Canales

  • Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway

    Kevin M. Elias;Kevin M. Elias;Arian Laurence;Todd S. Davidson;Geoffrey Stephens

  • Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature

    Pawel Muranski;Zachary A. Borman;Sid P. Kerkar;Christopher A. Klebanoff

  • Janus kinase inhibitors in autoimmune diseases

    John J O'Shea;Apostolos Kontzias;Kunihiro Yamaoka;Yoshiya Tanaka

  • Distinct regulation of interleukin‐17 in human T helper lymphocytes

    Zhi Chen;Cristina M. Tato;Linda Muul;Arian Laurence

  • Regulation of MicroRNA Expression and Abundance during Lymphopoiesis

    Stefan Kuchen;Wolfgang Resch;Arito Yamane;Nan Kuo

  • Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation

    Zhi Chen;Arian Laurence;John J. O'Shea

Frequent Co-Authors

John J. O'Shea
John J. O'Shea National Institutes of Health
Yuka Kanno
Yuka Kanno National Institutes of Health
Kiyoshi Hirahara
Kiyoshi Hirahara Chiba University
Kamran Ghoreschi
Kamran Ghoreschi Charité - University Medicine Berlin
Hong-Wei Sun
Hong-Wei Sun National Institutes of Health
Alejandro V. Villarino
Alejandro V. Villarino National Institutes of Health
Holm H. Uhlig
Holm H. Uhlig University of Oxford
Ethan M. Shevach
Ethan M. Shevach National Institute of Allergy and Infectious Diseases
Joshua D. Milner
Joshua D. Milner Columbia University
Claudia Kemper
Claudia Kemper National Institutes of Health

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