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Kiyoshi Hirahara

Kiyoshi Hirahara

D-Index & Metrics

Immunology

D-Index
47
Citations
9168
World Ranking
4509
National Ranking
173

Overview

Kiyoshi Hirahara is affiliated with Chiba University in Japan and has a substantial body of research contributions primarily in the fields of Medicine and Immunology and Microbiology. Their work spans several key subfields, including Immunology, Physiology, Surgery, Infectious Diseases, and Oncology.

The scientist's research focuses on main topics such as IL-33, ST2, and ILC Pathways, Asthma and respiratory diseases, Immune Cell Function and Interaction, T-cell and B-cell Immunology, Eosinophilic Esophagitis, COVID-19 Clinical Research Studies, and CAR-T cell therapy research.

Frequent publication venues for Hirahara include Allergology International, Proceedings of the National Academy of Sciences, Frontiers in Immunology, Immunity, and the Journal of Allergy and Clinical Immunology.

Some recent papers authored by or connected to Hirahara are:

  • The roles of tertiary lymphoid structures in chronic diseases (2023, Nature Reviews Nephrology)
  • Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis (2022, Frontiers in Immunology)
  • Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells (2020, Immunity)
  • Eosinophils: Cells known for over 140 years with broad and new functions (2020, Allergology International)
  • Interleukin-33-activated neuropeptide CGRP-producing memory Th2 cells cooperate with somatosensory neurons to induce conjunctival itch (2022, Immunity)

Hirahara collaborates regularly with a set of frequent co-authors whose partnerships have contributed to multiple publications. These co-authors include Masahiro Kiuchi, Toshinori Nakayama, Kota Kokubo, Chiaki Iwamura, and Atsushi Onodera.

The scientist's research contributions are well represented in topics surrounding immune system mechanisms and respiratory disease studies, indicating a multidisciplinary approach that integrates cellular immunology with clinical research. Their involvement in emerging areas such as CAR-T cell therapy and COVID-19 clinical research also reflects engagement with current biomedical challenges.

Best Publications

  • Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5.

    Xiang Ping Yang;Kamran Ghoreschi;Scott M. Steward-Tharp;Jaime Rodriguez-Canales

  • CD4+ T cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm

    Kiyoshi Hirahara;Toshinori Nakayama

  • BACH2 represses effector programs to stabilize T reg -mediated immune homeostasis

    Rahul Roychoudhuri;Kiyoshi Hirahara;Kiyoshi Hirahara;Kambiz Mousavi;David Clever

  • Th2 Cells in Health and Disease.

    Toshinori Nakayama;Kiyoshi Hirahara;Atsushi Onodera;Yusuke Endo

  • Transcriptional and Epigenetic Control of T Helper Cell Specification: Molecular Mechanisms Underlying Commitment and Plasticity*

    Yuka Kanno;Golnaz Vahedi;Kiyoshi Hirahara;Kentner Singleton

  • TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.

    Hayato Takahashi;Tomohiko Kanno;Shingo Nakayamada;Kiyoshi Hirahara

  • Interleukin-27 Priming of T Cells Controls IL-17 Production In trans via Induction of the Ligand PD-L1

    Kiyoshi Hirahara;Kamran Ghoreschi;Xiang-Ping Yang;Hayato Takahashi

  • Signal transduction pathways and transcriptional regulation in Th17 cell differentiation

    Kiyoshi Hirahara;Kamran Ghoreschi;Arian Laurence;Xiang-Ping Yang

  • T helper 17 cell heterogeneity and pathogenicity in autoimmune disease.

    Kamran Ghoreschi;Arian Laurence;Xiang Ping Yang;Kiyoshi Hirahara

  • The roles of tertiary lymphoid structures in chronic diseases

    Unknown

  • The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway

    Yusuke Endo;Kiyoshi Hirahara;Tomohisa Iinuma;Kenta Shinoda

  • Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1.

    Yusuke Endo;Hikari K. Asou;Nao Matsugae;Kiyoshi Hirahara

  • Amphiregulin-Producing Pathogenic Memory T Helper 2 Cells Instruct Eosinophils to Secrete Osteopontin and Facilitate Airway Fibrosis.

    Yuki Morimoto;Kiyoshi Hirahara;Masahiro Kiuchi;Tomoko Wada

  • Mechanisms underlying helper T-cell plasticity: Implications for immune-mediated disease

    Kiyoshi Hirahara;Amanda Poholek;Golnaz Vahedi;Arian Laurence

  • Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function

    Yukiko I. Nigo;Masakatsu Yamashita;Kiyoshi Hirahara;Ryo Shinnakasu

  • Distinct requirements for T-bet in gut innate lymphoid cells.

    Giuseppe Sciumé;Kiyoshi Hirahara;Hayato Takahashi;Arian Laurence

  • Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells

    Renu Jain;Yi Chen;Yuka Kanno;Barbara Joyce-Shaikh

  • Crucial Role of MLL for the Maintenance of Memory T Helper Type 2 Cell Responses

    Masakatsu Yamashita;Kiyoshi Hirahara;Ryo Shinnakasu;Hiroyuki Hosokawa

  • Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.

    Kiyoshi Hirahara;Kiyoshi Hirahara;Atsushi Onodera;Alejandro V. Villarino;Michael Bonelli

  • Recent advances in understanding psoriasis.

    Franziska C. Eberle;Jürgen Brück;Julia Holstein;Kiyoshi Hirahara

  • BACH2 represses effector programmes to stabilize Treg-mediated immune homeostasis - a new target in tumor immunotherapy?

    Rahul Roychoudhuri;Kiyoshi Hirahara;Kambiz Mousavi;David Clever

Frequent Co-Authors

Toshinori Nakayama
Toshinori Nakayama Chiba University
John J. O'Shea
John J. O'Shea National Institutes of Health
Yuka Kanno
Yuka Kanno National Institutes of Health
Arian Laurence
Arian Laurence University of Oxford
Yoshitaka Okamoto
Yoshitaka Okamoto Chiba University
Kamran Ghoreschi
Kamran Ghoreschi Charité - University Medicine Berlin
Hong-Wei Sun
Hong-Wei Sun National Institutes of Health
Alejandro V. Villarino
Alejandro V. Villarino National Institutes of Health
Masakatsu Yamashita
Masakatsu Yamashita Ehime University
Satoshi Uematsu
Satoshi Uematsu Osaka Metropolitan University

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