World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
13342
World Ranking
12471
National Ranking
5336

Research.com Recognitions

  • 1933 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Gilbert H. Smith was affiliated with the National Institutes of Health in the United States. Their research career focused extensively on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with an emphasis on Oncology and Molecular Biology as subfields.

The scientist's main research topics included:

  • HER2/EGFR in Cancer Research
  • Cancer Cells and Metastasis
  • Cancer Immunotherapy and Biomarkers
  • Mitochondrial Function and Pathology
  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer

Smith contributed to the scientific community through multiple peer-reviewed papers, all published in the journal Oncotarget. Selected recent papers include:

  • Induction of phenotypic changes in HER2-postive breast cancer cells in vivo and in vitro (2020), Oncotarget
  • Correction: Induction of phenotypic changes in HER2-postive breast cancer cells in vivo and in vitro (2023), Oncotarget
  • Sequence conservation of mitochondrial (mt)DNA during expansion of clonal mammary epithelial populations suggests a common mtDNA template in CzechII mice (2020), Oncotarget

Throughout their research, Smith collaborated frequently with a number of co-authors, including:

  • Corinne A. Boulanger
  • Lauren E. Ragle
  • Anastasia Frank-Kamenetskii
  • Julia M. Mook
  • Meredith Reeves

Smith was recognized by their peers and received the title of Fellow of the American Association for the Advancement of Science (AAAS) in 1933.

Best Publications

  • Notch signaling is essential for vascular morphogenesis in mice.

    Luke T. Krebs;Yingzi Xue;Christine R. Norton;John R. Shutter

  • TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas.

    Chamelli Jhappan;Cheryl Stahle;Richard N. Harkins;Nelson Fausto

  • An entire functional mammary gland may comprise the progeny from a single cell

    Edith C. Kordon;Gilbert H. Smith

  • Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands.

    C Jhappan;D Gallahan;C Stahle;E Chu

  • Label-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strands.

    Gilbert H. Smith

  • Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation

    Gertraud W. Robinson;Robert A. McKnight;Gilbert H. Smith;Lothar Hennighausen

  • Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium

    Keiko Miyoshi;Jonathan M. Shillingford;Gilbert H. Smith;Sandra L. Grimm

  • An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal.

    Kay Uwe Wagner;Corinne A. Boulanger;Ma Linda D. Henry;Magdalene Sgagias

  • Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation.

    C Jhappan;A G Geiser;E C Kordon;D Bagheri

  • Expression of a Truncated Int3 Gene in Developing Secretory Mammary Epithelium Specifically Retards Lobular Differentiation Resulting in Tumorigenesis

    Daniel Gallahan;Chamelli Jhappan;Gertraud Robinson;Lothar Hennighausen

  • Mammary Epithelial Stem Cells

    Gilbert H. Smith;Gloria Chepko

  • MMTV-induced mammary tumorigenesis: gene discovery, progression to malignancy and cellular pathways.

    Robert Callahan;Gilbert H Smith

  • Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-β1 expression

    Corinne A. Boulanger;Kay Uwe Wagner;Gilbert H. Smith

  • Re-evaluation of mammary stem cell biology based on in vivo transplantation.

    Gilbert H Smith;Daniel Medina

  • Int-6, a highly conserved, widely expressed gene, is mutated by mouse mammary tumor virus in mammary preneoplasia.

    A Marchetti;F Buttitta;S Miyazaki;D Gallahan

  • Interaction with the mammary microenvironment redirects spermatogenic cell fate in vivo

    Corinne A. Boulanger;David L. Mack;Brian W. Booth;Gilbert H. Smith

  • Constitutive Expression of a Truncated INT3 Gene in Mouse Mammary Epithelium Impairs Differentiation and Functional Development

    Gilbert H. Smith;Daniel Gallahan;Francesca Diella;Chamelli Jhappan

  • Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice

    Ma Linda D. Henry;Aleata A. Triplett;Keon Bong Oh;Gilbert H. Smith

  • Distribution of intracisternal a-particles in a variety of normal and neoplastic mouse tissues

    Nelson A. Wivel;Gilbert H. Smith

  • Estrogen receptor-α and progesterone receptor are expressed in label-retaining mammary epithelial cells that divide asymmetrically and retain their template DNA strands

    Brian W Booth;Gilbert H Smith

Frequent Co-Authors

Robert Callahan
Robert Callahan National Institutes of Health
Daniel Medina
Daniel Medina Baylor College of Medicine
David S. Salomon
David S. Salomon National Institutes of Health
Lothar Hennighausen
Lothar Hennighausen National Institutes of Health
Glenn Merlino
Glenn Merlino National Institutes of Health
Gertraud W. Robinson
Gertraud W. Robinson National Institutes of Health
Giorgio R. Merlo
Giorgio R. Merlo University of Turin
Robert B. Dickson
Robert B. Dickson Georgetown University Medical Center
Fortunato Ciardiello
Fortunato Ciardiello University of Campania "Luigi Vanvitelli"
Masaharu Seno
Masaharu Seno Okayama University

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