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Biology and Biochemistry

D-Index
58
Citations
10947
World Ranking
13290
National Ranking
5655

Overview

Peter Bell is affiliated with the University of Pennsylvania in the United States. Their research primarily focuses on gene therapy, genetic engineering, and molecular biology, with a significant emphasis on virus-based gene therapy approaches.

Their recent publications highlight contributions to diverse areas including RNA interference, viral vector safety, and genome editing. Notable papers include:

  • MicroRNA-mediated inhibition of transgene expression reduces dorsal root ganglion toxicity by AAV vectors in primates, 2020, published in Science Translational Medicine
  • Integrated vector genomes may contribute to long-term expression in primate liver after AAV administration, 2023, published in Nature Biotechnology
  • Translational Feasibility of Lumbar Puncture for Intrathecal AAV Administration, 2020, published in Molecular Therapy - Methods & Clinical Development
  • A mutation-independent CRISPR-Cas9-mediated gene targeting approach to treat a murine model of ornithine transcarbamylase deficiency, 2020, published in Science Advances
  • Long-term stable reduction of low-density lipoprotein in nonhuman primates following in vivo genome editing of PCSK9, 2021, published in Molecular Therapy

Peter Bell has collaborated frequently with several coauthors, including:

  • James M. Wilson
  • Elizabeth L. Buza
  • Yanqing Zhu
  • Jessica A. Chichester
  • Zhenning He

Their publications have appeared primarily in journals specializing in gene therapy and molecular medicine, with frequent contributions to:

  • Molecular Therapy - Methods & Clinical Development
  • Molecular Therapy
  • Human Gene Therapy
  • Science Translational Medicine
  • Nature Biotechnology

The main fields of study covered by Peter Bell's work are:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these, they have specialized subfields including:

  • Genetics
  • Molecular Biology
  • Epidemiology
  • Cardiology and Cardiovascular Medicine
  • Oncology

The research topics consistently addressed in their publications include:

  • Virus-based gene therapy research
  • CRISPR and Genetic Engineering
  • RNA Interference and Gene Delivery
  • Viral Infections and Immunology Research
  • CAR-T cell therapy research
  • Animal Virus Infections Studies
  • Mechanical Circulatory Support Devices

Best Publications

  • Severe Toxicity in Nonhuman Primates and Piglets Following High-Dose Intravenous Administration of an Adeno-Associated Virus Vector Expressing Human SMN

    Christian Hinderer;Nathan Katz;Elizabeth Lynne Buza;Cecilia Dyer

  • A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice

    Yang Yang;Lili Wang;Peter Bell;Deirdre McMenamin

  • Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation

    Kasirajan Ayyanathan;Mark S. Lechner;Peter Bell;Gerd G. Maul

  • Review: properties and assembly mechanisms of ND10, PML bodies, or PODs.

    Gerd G. Maul;Dmitri Negorev;Peter Bell;Alexander M. Ishov

  • The Neurotropic Properties of AAV-PHP.B Are Limited to C57BL/6J Mice.

    Juliette Hordeaux;Qiang Wang;Nathan Katz;Elizabeth L. Buza

  • Total correction of hemophilia A mice with canine FVIII using an AAV 8 serotype.

    Rita Sarkar;Renee Tetreault;Guangping Gao;Lili Wang

  • Dosage Thresholds for AAV2 and AAV8 Photoreceptor Gene Therapy in Monkey

    Luk H. Vandenberghe;Peter Bell;Albert M. Maguire;Albert M. Maguire;Cassia N. Cearley;Cassia N. Cearley

  • CpG-depleted adeno-associated virus vectors evade immune detection

    Susan M. Faust;Peter Bell;Benjamin J. Cutler;Scott N. Ashley

  • The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice

    Christie L. Bell;Luk H. Vandenberghe;Peter Bell;Maria P. Limberis

  • Impact of Pre-Existing Immunity on Gene Transfer to Nonhuman Primate Liver with Adeno-Associated Virus 8 Vectors

    Lili Wang;Roberto Calcedo;Peter Bell;Jianping Lin

  • Biology of AAV Serotype Vectors in Liver-Directed Gene Transfer to Nonhuman Primates

    Guangping Gao;You Lu;Roberto Calcedo;Rebecca L. Grant

  • Reassessment of the Roles of Integrase and the Central DNA Flap in Human Immunodeficiency Virus Type 1 Nuclear Import

    Jeffrey D. Dvorin;Peter Bell;Gerd G. Maul;Masahiro Yamashita

  • The GPI-Linked Protein LY6A Drives AAV-PHP.B Transport across the Blood-Brain Barrier.

    Juliette Hordeaux;Yuan Yuan;Peter M. Clark;Qiang Wang

  • Analysis of Tumors Arising in Male B6C3F1 Mice with and without AAV Vector Delivery to Liver

    Peter Bell;A. David Moscioni;Robert J. McCarter;Di Wu

  • No evidence for tumorigenesis of AAV vectors in a large-scale study in mice.

    Peter Bell;Lili Wang;Corinna Lebherz;Douglas B. Flieder

  • Resolution of Primary Severe Acute Respiratory Syndrome-Associated Coronavirus Infection Requires Stat1

    Robert J. Hogan;Guangping Gao;Thomas Rowe;Peter Bell

  • The pleiotropic effects of natural AAV infections on liver-directed gene transfer in macaques

    Lili Wang;Roberto Calcedo;Huan Wang;Huan Wang;Peter Bell

  • Lytic but Not Latent Replication of Epstein-Barr Virus Is Associated with PML and Induces Sequential Release of Nuclear Domain 10 Proteins

    Peter Bell;Paul M. Lieberman;Gerd G. Maul

  • Systematic evaluation of AAV vectors for liver directed gene transfer in murine models.

    Lili Wang;Huan Wang;Huan Wang;Peter Bell;Robert J McCarter

  • Human CRB1-associated retinal degeneration: comparison with the rd8 Crb1-mutant mouse model.

    Tomas S. Aleman;Artur V. Cideciyan;Geoffrey K. Aguirre;Wei Chieh Huang

Frequent Co-Authors

James M. Wilson
James M. Wilson University of Pennsylvania
Roberto Calcedo
Roberto Calcedo Affinia Therapeutics
Guangping Gao
Guangping Gao University of Massachusetts Chan Medical School
Luk H. Vandenberghe
Luk H. Vandenberghe Massachusetts Eye and Ear Infirmary
Gerd G. Maul
Gerd G. Maul The Wistar Institute
Albert M. Maguire
Albert M. Maguire University of Pennsylvania
Daniel J. Rader
Daniel J. Rader University of Pennsylvania
Jean Bennett
Jean Bennett University of Pennsylvania
Mingyao Li
Mingyao Li University of Pennsylvania
Samuel G. Jacobson
Samuel G. Jacobson University of Pennsylvania

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