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Immunology

D-Index
52
Citations
12931
World Ranking
4035
National Ranking
1843

Overview

Roberto Calcedo is affiliated with Affinia Therapeutics in the United States and works extensively in the fields of Biochemistry, Genetics, and Molecular Biology, with a significant focus on Medicine. Their research spans several subfields including Genetics, Cellular and Molecular Neuroscience, Epidemiology, Oncology, and Molecular Biology.

The main topics of their work involve virus-based gene therapy research, herpesvirus infections and treatments, CAR-T cell therapy research, animal virus infections studies, photoreceptor and optogenetics research, molecular communication and nanonetworks, and neuroscience and neural engineering.

Roberto Calcedo has contributed to multiple publications, with recent work appearing in respected scientific journals. Some of these publications include:

  • MicroRNA-mediated inhibition of transgene expression reduces dorsal root ganglion toxicity by AAV vectors in primates (2020), published in Science Translational Medicine
  • An Open Resource for Non-human Primate Optogenetics (2020), published in Neuron
  • Adenovirus-Antibody Complexes Contributed to Lethal Systemic Inflammation in a Gene Therapy Trial (2020), published in Molecular Therapy
  • Intrathecal Gene Therapy for Giant Axonal Neuropathy (2024), published in New England Journal of Medicine
  • Isolating Human Monoclonal Antibodies Against Adeno-Associated Virus From Donors With Pre-existing Immunity (2020), published in Frontiers in Immunology

The most frequent publication venues for their work include:

  • Science Translational Medicine
  • Neuron
  • New England Journal of Medicine
  • Molecular Therapy
  • Frontiers in Immunology

Among the frequent collaborators of Roberto Calcedo are:

  • James M. Wilson
  • Jessica A. Chichester
  • Juliette Hordeaux
  • Elizabeth L. Buza
  • Brianne A Jeffrey

Best Publications

  • Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

    Guang-Ping Gao;Mauricio R. Alvira;Lili Wang;Roberto Calcedo

  • Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues

    Guangping Gao;Luk H. Vandenberghe;Mauricio R. Alvira;You Lu

  • Worldwide Epidemiology of Neutralizing Antibodies to Adeno-Associated Viruses

    Roberto Calcedo;Luk H. Vandenberghe;Guangping Gao;Jianping Lin

  • Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial

    Eric W F W Alton;David K Armstrong;Deborah Ashby;Katie J Bayfield

  • Adeno-associated viruses undergo substantial evolution in primates during natural infections.

    Guangping Gao;Mauricio R. Alvira;Suryanarayan Somanathan;You Lu

  • Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy

    Mark L. Brantly;Jeffrey D. Chulay;Lili Wang;Christian Mueller

  • Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing α1-antitrypsin: interim results.

    Terence R. Flotte;Bruce C. Trapnell;Margaret Humphries;Brenna Carey

  • Adeno-Associated Virus Antibody Profiles in Newborns, Children, and Adolescents

    Roberto Calcedo;Hiroki Morizono;Lili Wang;Robert McCarter

  • Humoral Immune Response to AAV.

    Roberto Calcedo;James M Wilson

  • Dosage Thresholds for AAV2 and AAV8 Photoreceptor Gene Therapy in Monkey

    Luk H. Vandenberghe;Peter Bell;Albert M. Maguire;Albert M. Maguire;Cassia N. Cearley;Cassia N. Cearley

  • Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid

    Luk H Vandenberghe;Lili Wang;Suryanarayan Somanathan;Yan Zhi

  • Impact of Pre-Existing Immunity on Gene Transfer to Nonhuman Primate Liver with Adeno-Associated Virus 8 Vectors

    Lili Wang;Roberto Calcedo;Peter Bell;Jianping Lin

  • Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy

    Lili Wang;Lili Wang;Lili Wang;Roberto Calcedo;Roberto Calcedo;Roberto Calcedo;Timothy C. Nichols;Timothy C. Nichols;Timothy C. Nichols;Dwight A. Bellinger;Dwight A. Bellinger;Dwight A. Bellinger

  • Erythropoietin gene therapy leads to autoimmune anemia in macaques

    Guangping Gao;Corinna Lebherz;Daniel J. Weiner;Rebecca Grant

  • Biology of AAV Serotype Vectors in Liver-Directed Gene Transfer to Nonhuman Primates

    Guangping Gao;You Lu;Roberto Calcedo;Rebecca L. Grant

  • Isolation and Characterization of Adenoviruses Persistently Shed from the Gastrointestinal Tract of Non-Human Primates

    Soumitra Roy;Luk H. Vandenberghe;Sergey Kryazhimskiy;Rebecca Grant

  • Human Treg responses allow sustained recombinant adeno-associated virus- mediated transgene expression

    Christian Mueller;Jeffrey D. Chulay;Bruce C. Trapnell;Margaret Humphries

  • Noninvasive gene transfer to the lung for systemic delivery of therapeutic proteins

    Alberto Auricchio;Erin O’Connor;Daniel Weiner;Guang-Ping Gao

  • Cross-presentation of adeno-associated virus serotype 2 capsids activates cytotoxic T cells but does not render hepatocytes effective cytolytic targets.

    Lili Wang;Joanita Figueredo;Roberto Calcedo;Jianping Lin

  • Evaluation of toxicity from high-dose systemic administration of recombinant adenovirus vector in vector-naive and pre-immunized mice.

    A N Varnavski;R Calcedo;R Calcedo;M Bove;M Bove;G Gao;G Gao

Frequent Co-Authors

James M. Wilson
James M. Wilson University of Pennsylvania
Guangping Gao
Guangping Gao University of Massachusetts Chan Medical School
Peter Bell
Peter Bell University of Pennsylvania
Luk H. Vandenberghe
Luk H. Vandenberghe Massachusetts Eye and Ear Infirmary
David J. Porteous
David J. Porteous University of Edinburgh
Uta Griesenbach
Uta Griesenbach National Institutes of Health
Eric W.F.W. Alton
Eric W.F.W. Alton National Institutes of Health
Ronald K. Scheule
Ronald K. Scheule Sanofi (United States)
Duncan M. Geddes
Duncan M. Geddes Imperial College London
Keith Smith
Keith Smith University of Edinburgh

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