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Biology and Biochemistry

D-Index
58
Citations
15015
World Ranking
13015
National Ranking
325

Overview

Jan Wijnholds is affiliated with Leiden University Medical Center in the Netherlands. Their research spans multiple interconnected areas within biomedicine, primarily focusing on molecular and genetic aspects of retinal development and disorders.

The main fields of study for Wijnholds include Biochemistry, Genetics and Molecular Biology, and Medicine. Within these, the scientist's work is particularly concentrated in subfields such as Molecular Biology, Ophthalmology, Genetics, Radiology, Nuclear Medicine and Imaging, and Cellular and Molecular Neuroscience.

The research topics covered by Wijnholds prominently feature:

  • Retinal Development and Disorders
  • CRISPR and Genetic Engineering
  • Virus-based gene therapy research
  • Retinal Diseases and Treatments
  • Retinal and Macular Surgery
  • Photoreceptor and optogenetics research
  • Cellular transport and secretion

Wijnholds is known to have published extensively in several scientific journals. The most frequent venues for their work include:

  • International Journal of Molecular Sciences
  • Stem Cell Reports
  • Frontiers in Neuroscience
  • Molecular Therapy - Methods & Clinical Development
  • Acta Ophthalmologica

Significant recent papers by Jan Wijnholds include:

  • Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays, 2020, International Journal of Molecular Sciences
  • mRNA trans-splicing dual AAV vectors for (epi)genome editing and gene therapy, 2023, Nature Communications
  • AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype, 2023, Stem Cell Reports
  • CRB1-Associated Retinal Dystrophies: A Prospective Natural History Study in Anticipation of Future Clinical Trials, 2021, American Journal of Ophthalmology
  • RPGR-Associated Dystrophies: Clinical, Genetic, and Histopathological Features, 2020, International Journal of Molecular Sciences

The scientist collaborates frequently with other researchers in their field. Notable coauthors with multiple joint publications include:

  • Nanda Boon
  • Thilo M. Buck
  • Charlotte A. Andriessen
  • Xuefei Lu
  • Mays Talib

Best Publications

  • A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins

    Piet Borst;Raymond Evers;Marcel Kool;Jan Wijnholds

  • The multidrug resistance protein family.

    Piet Borst;Raymond Evers;Marcel Kool;Jan Wijnholds

  • The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.

    Glen Reid;Pieter Wielinga;Noam Zelcer;Ingrid van der Heijden

  • Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

    J Wijnholds;C A Mol;L van Deemter;M de Haas

  • Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein.

    J. Wijnholds;R. Evers;M. R. Van Leusden;C. A. A. M. Mol

  • The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin.

    John D. Allen;Remco F. Brinkhuis;Jan Wijnholds;Alfred H. Schinkel

  • Characterization of the Transport of Nucleoside Analog Drugs by the Human Multidrug Resistance Proteins MRP4 and MRP5

    Glen Reid;Peter Wielinga;Noam Zelcer;Marcel de Haas

  • Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

    Jan Wijnholds;Elizabeth C.M. de Lange;George L. Scheffer;Dirk-Jan van den Berg

  • Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells.

    Peter R. Wielinga;Ingrid van der Heijden;Glen Reid;Jos H. Beijnen

  • Specific Detection of Multidrug Resistance Proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-Glycoprotein with a Panel of Monoclonal Antibodies

    George L. Scheffer;Marcel Kool;Marc Heijn;Marcel de Haas

  • Multidrug Resistance Protein 1 Protects the Oropharyngeal Mucosal Layer and the Testicular Tubules against Drug-induced Damage

    Jan Wijnholds;George L. Scheffer;Martin van der Valk;Paul van der Valk

  • Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure.

    Serge A. van de Pavert;Albena Kantardzhieva;Anna Malysheva;Jan Meuleman

  • Extensive Contribution of the Multidrug Transporters P-Glycoprotein and Mrp1 to Basal Drug Resistance

    John D. Allen;Remco F. Brinkhuis;Liesbeth van Deemter;Jan Wijnholds

  • Noninvasive, In Vivo Assessment of Mouse Retinal Structure Using Optical Coherence Tomography

    M. Dominik Fischer;Gesine Huber;Gesine Huber;Susanne C. Beck;Naoyuki Tanimoto

  • TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals.

    Heidi Stöhr;Julia B. Heisig;Peter M. Benz;Simon Schöberl

  • Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells.

    Pieter Wielinga;G. Reid;E. E. Challa;I. van der Heijden

  • Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides

    Noam Zelcer;Noam Zelcer;Koen van de Wetering;Rudi de Waart;George L. Scheffer

  • The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes

    Tobias Minich;Jan Riemer;Jörg B. Schulz;Peter Wielinga

  • Pseudoxanthoma elasticum: a clinical, histopathological, and molecular update.

    Xiaofeng Hu;Astrid S. Plomp;Simone van Soest;Jan Wijnholds

  • In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy

    Mathias W. Seeliger;Susanne C. Beck;Naira Pereyra-Muñoz;Susann Dangel

Frequent Co-Authors

Mathias W. Seeliger
Mathias W. Seeliger University of Tübingen
Piet Borst
Piet Borst Antoni van Leeuwenhoek Hospital
Arthur A.B. Bergen
Arthur A.B. Bergen University of Amsterdam
Caroline C W Klaver
Caroline C W Klaver Erasmus University Rotterdam
Frans P.M. Cremers
Frans P.M. Cremers Radboud University
Jos H. Beijnen
Jos H. Beijnen Utrecht University
George L. Scheffer
George L. Scheffer VU University Medical Center
John G. Flannery
John G. Flannery University of California, Berkeley
André Le Bivic
André Le Bivic Centre national de la recherche scientifique, CNRS
Carel B. Hoyng
Carel B. Hoyng Radboud University

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