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Medicine

D-Index
92
Citations
33015
World Ranking
11258
National Ranking
5780

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Keith A. Hruska is affiliated with Washington University in St. Louis in the United States. Their research primarily focuses on medicine, with significant contributions in biochemistry, genetics, and molecular biology. Within these broad fields, their work particularly emphasizes nephrology, genetics, and molecular biology, with additional studies in pulmonary and respiratory medicine and epidemiology.

The main topics explored in their research include parathyroid disorders and treatments, dermatological and skeletal disorders, genetic syndromes and imprinting, electrolyte and hormonal disorders, urinary tract infections management, pediatric urology and nephrology studies, and chronic kidney disease and diabetes.

Frequent coauthors in their work include Matthew J. Williams, Zachary Joseph, Carmen M. Halabi, Hiral Patel, and Hartmut H. Malluche.

Keith A. Hruska has published extensively in the following venues:

  • Journal of the American Society of Nephrology
  • Frontiers in Immunology
  • Frontiers in Physiology
  • American Journal of Physiology-Renal Physiology
  • bioRxiv (Cold Spring Harbor Laboratory)

Recent significant papers authored include:

  • Androgen-Influenced Polarization of Activin A-Producing Macrophages Accompanies Post-pyelonephritic Renal Scarring, 2020, Frontiers in Immunology
  • Updates in the chronic kidney disease-mineral bone disorder show the role of osteocytic proteins, a potential mechanism of the bone-Vascular paradox, a therapeutic target, and a biomarker, 2023, Frontiers in Physiology
  • In chronic kidney disease altered cardiac metabolism precedes cardiac hypertrophy, 2024, American Journal of Physiology-Renal Physiology
  • The Impact of a Western Diet High in Phosphate on the CKD-MBD in an Alport Syndrome Model, 2025, bioRxiv (Cold Spring Harbor Laboratory)
  • Acidosis in CKD May Affect Mineralization of Newly Formed Bone According to HR-pQCT and Quantitative Back Scatter Electron Imaging, 2023, Journal of the American Society of Nephrology

Their work has explored a range of clinical and molecular topics including renal scarring mechanisms, chronic kidney disease-mineral bone disorder (CKD-MBD), cardiac metabolism changes in kidney disease, diet impacts on genetic kidney conditions, and bone mineralization affected by acidosis in chronic kidney disease.

Keith A. Hruska has been recognized as a member of the Association of American Physicians.

Best Publications

  • Osteoporosis prevention, diagnosis, and therapy

    Anne Klibanski;Lucile Adams-Campbell;Tamsen Bassford;Steven N. Blair

  • K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease

    Shaul G. Massry;Jack W. Coburn;Glenn M. Chertow;Keith Hruska

  • Protein transduction: unrestricted delivery into all cells?

    Steven R. Schwarze;Keith A. Hruska;Steven F. Dowdy

  • Vascular calcification in chronic kidney disease.

    William G Goodman;Gerard London;Kerstin Amann;Geoffrey A Block

  • Hyperphosphatemia of chronic kidney disease

    Keith A. Hruska;Suresh Mathew;Richard Lund;Ping Qiu

  • Bone Morphogenetic Proteins in Vascular Calcification

    Keith A. Hruska;Suresh Mathew;Georges Saab

  • Metabolism in immunoreactive parathyroid hormone in the dog. The role of the kidney and the effects of chronic renal disease.

    K A Hruska;R Kopelman;W E Rutherford;S Klahr

  • Bone Morphogenetic Protein-7 Improves Renal Fibrosis and Accelerates the Return of Renal Function

    Jeremiah Morrissey;Keith Hruska;Guangjie Guo;Song Wang

  • Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction

    Keith A. Hruska;Guangjie Guo;Magdalena Wozniak;Daniel Martin

  • Pathophysiological mechanisms of vascular calcification in end-stage renal disease.

    Matthew R. Davies;Keith A. Hruska

  • Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy.

    Song Wang;Qing Chen;Qing Chen;Theodore C. Simon;Theodore C. Simon;Frank Strebeck;Frank Strebeck

  • A microRNA expression signature of osteoclastogenesis

    Toshifumi Sugatani;Jean Vacher;Keith A. Hruska

  • Gelsolin Deficiency Blocks Podosome Assembly and Produces Increased Bone Mass and Strength

    Meenakshi A. Chellaiah;Neil Kizer;Matthew Silva;Ulises Alvarez

  • The Mechanism of Phosphorus as a Cardiovascular Risk Factor in CKD

    Suresh Mathew;Kimberly S. Tustison;Toshifumi Sugatani;Lala R. Chaudhary

  • Osteopontin Deficiency Produces Osteoclast Dysfunction Due to Reduced CD44 Surface Expression

    Meenakshi A. Chellaiah;Neil Kizer;Rajat Biswas;Ulises Alvarez

  • Rho-A is critical for osteoclast podosome organization, motility, and bone resorption.

    Meenakshi A. Chellaiah;Norihito Soga;Suzanne Swanson;Sandy McAllister

  • Wnt-Dependent β-Catenin Signaling Is Activated after Unilateral Ureteral Obstruction, and Recombinant Secreted Frizzled-Related Protein 4 Alters the Progression of Renal Fibrosis

    Kameswaran Surendran;Susan Schiavi;Keith A. Hruska

  • The Peripheral Metabolism of Parathyroid Hormone

    Kevin J. Martin;Keith A. Hruska;Jeffrey J. Freitag;Saulo Klahr

  • BMP-7 Is an Efficacious Treatment of Vascular Calcification in a Murine Model of Atherosclerosis and Chronic Renal Failure

    Matthew R. Davies;Richard J. Lund;Keith A. Hruska

  • Impaired micro-RNA pathways diminish osteoclast differentiation and function.

    Toshifumi Sugatani;Keith A. Hruska

Frequent Co-Authors

Eduardo Slatopolsky
Eduardo Slatopolsky Washington University in St. Louis
Saulo Klahr
Saulo Klahr Washington University in St. Louis
Louis V. Avioli
Louis V. Avioli Washington University in St. Louis
Steven L. Teitelbaum
Steven L. Teitelbaum Washington University in St. Louis
Barry I. Freedman
Barry I. Freedman Wake Forest University
J. Jeffrey Carr
J. Jeffrey Carr Vanderbilt University Medical Center
Donald W. Bowden
Donald W. Bowden Wake Forest University
Carl D. Langefeld
Carl D. Langefeld Wake Forest University
Anna Teti
Anna Teti University of L'Aquila
Lynne E. Wagenknecht
Lynne E. Wagenknecht Wake Forest University

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