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Herbert Y. Gaisano

Herbert Y. Gaisano

D-Index & Metrics

Biology and Biochemistry

D-Index
69
Citations
12433
World Ranking
7584
National Ranking
261

Overview

Herbert Y. Gaisano is affiliated with the University of Toronto in Canada. Their research primarily focuses on medicine with particular emphasis on biochemistry, genetics, and molecular biology. The subfields most frequently addressed include surgery, endocrinology, diabetes and metabolism, epidemiology, molecular biology, and cardiology and cardiovascular medicine.

The scientist's work revolves around several central topics such as pancreatic function and diabetes, pancreatitis pathology and treatment, cellular transport and secretion, diabetes management and research, diabetes linked with cardiovascular risks and lipoproteins, adipokines, inflammation, and metabolic diseases, as well as diabetes treatment and management.

Recent publications highlight their contributions to the understanding of metabolic and pancreatic diseases. Notable papers include:

  • "Elevated triglyceride-glucose (TyG) index predicts incidence of Prediabetes: a prospective cohort study in China," published in 2020 in Lipids in Health and Disease
  • "Relationship of obesity to adipose tissue insulin resistance," published in 2020 in BMJ Open Diabetes Research & Care
  • "Gut microbiome modified by bariatric surgery improves insulin sensitivity and correlates with increased brown fat activity and energy expenditure," published in 2023 in Cell Reports Medicine
  • "Dysregulation of mannose-6-phosphate-dependent cholesterol homeostasis in acinar cells mediates pancreatitis," published in 2021 in Journal of Clinical Investigation
  • "Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes," published in 2020 in Autophagy

Frequent collaborators in their research include Fei Kang, Yan He, Yingting Zuo, Qi Zhai, and Jiajia Jiang. The scientist has also contributed extensively to several high-profile publication venues such as bioRxiv (Cold Spring Harbor Laboratory), BMJ Open Diabetes Research & Care, iScience, Diabetes Obesity and Metabolism, and Endocrine.

The body of work conducted by Herbert Y. Gaisano integrates clinical and molecular perspectives on pancreatic diseases, metabolic dysfunctions, and diabetes-related complications. Their publications reflect a strong interdisciplinary approach, merging surgery, endocrinology, and molecular biology to address complex health issues.

Best Publications

  • Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion

    N. Wijesekara;F. F. Dai;A. B. Hardy;P. R. Giglou

  • Characterization of SNARE protein expression in beta cell lines and pancreatic islets.

    M B Wheeler;L Sheu;M Ghai;A Bouquillon

  • Impaired Gene and Protein Expression of Exocytotic Soluble N-Ethylmaleimide Attachment Protein Receptor Complex Proteins in Pancreatic Islets of Type 2 Diabetic Patients

    Claes-Goran Ostenson;Herbert Gaisano;Laura Sheu;Annika Tibell

  • Members of the Kv1 and Kv2 Voltage-Dependent K+ Channel Families Regulate Insulin Secretion

    Patrick E. MacDonald;Xiao Fang Ha;Jing Wang;Simon R. Smukler

  • Distinct cellular locations of the syntaxin family of proteins in rat pancreatic acinar cells.

    H Y Gaisano;M Ghai;P N Malkus;L Sheu

  • Disruption of Pancreatic β-Cell Lipid Rafts Modifies Kv2.1 Channel Gating and Insulin Exocytosis

    Fuzhen Xia;Xiaodong Gao;Edwin Kwan;Patrick P.L. Lam

  • Gut-associated IgA+ immune cells regulate obesity-related insulin resistance

    Helen Luck;Helen Luck;Saad Khan;Saad Khan;Justin H. Kim;Julia K. Copeland

  • Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice

    Benjamin J. Lamont;Yazhou Li;Edwin Kwan;Theodore J. Brown

  • Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells.

    Fuzhen Xia;Li Xie;Anton Mihic;Xiaodong Gao

  • Caspase-3-Dependent β-Cell Apoptosis in the Initiation of Autoimmune Diabetes Mellitus

    Nicole Liadis;Kiichi Murakami;Mohamed Eweida;Alisha R. Elford

  • α/β-Hydrolase Domain-6-Accessible Monoacylglycerol Controls Glucose-Stimulated Insulin Secretion

    Shangang Zhao;Yves Mugabo;Jose Iglesias;Li Xie

  • New Insights Into the Mechanisms of Pancreatitis

    Herbert Y. Gaisano;Fred S. Gorelick

  • Tetanus toxin light chain cleaves a vesicle-associated membrane protein (VAMP) isoform 2 in rat pancreatic zymogen granules and inhibits enzyme secretion.

    H Y Gaisano;L Sheu;J K Foskett;W S Trimble

  • Syntaxin 1A binds to the cytoplasmic C terminus of Kv2.1 to regulate channel gating and trafficking.

    Yuk M. Leung;Youhou Kang;Xiaodong Gao;Fuzhen Xia

  • Erythropoietin protects against diabetes through direct effects on pancreatic β cells

    Diana Choi;Stephanie A. Schroer;Shun Yan Lu;Linyuan Wang

  • Regulation of insulin exocytosis by Munc13-1

    Laura Sheu;Eva A. Pasyk;Junzhi Ji;Xiaohang Huang

  • Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatment.

    Herbert Y. Gaisano;Claes-Goran Ostenson;Laura Sheu;Michael B. Wheeler

  • Supramaximal cholecystokinin displaces Munc18c from the pancreatic acinar basal surface, redirecting apical exocytosis to the basal membrane

    Herbert Y. Gaisano;Manfred P. Lutz;Juergen Leser;Laura Sheu

  • SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans

    Xiao-Qing Dai;Greg Plummer;Marina Casimir;Youhou Kang

  • Truncated SNAP-25 (1–197), Like Botulinum Neurotoxin A, Can Inhibit Insulin Secretion from HIT-T15 Insulinoma Cells

    Xiaohang Huang;Michael B. Wheeler;You-hou Kang;Laura Sheu

Frequent Co-Authors

Michael B. Wheeler
Michael B. Wheeler University of Toronto
William S. Trimble
William S. Trimble University of Toronto
Per-Olof Berggren
Per-Olof Berggren Karolinska Institute
Vesa M. Olkkonen
Vesa M. Olkkonen University of Helsinki
Patricia L. Brubaker
Patricia L. Brubaker University of Toronto
Stephen J. Pandol
Stephen J. Pandol Cedars-Sinai Medical Center
Christopher B. Newgard
Christopher B. Newgard Duke University
Kris Chadee
Kris Chadee University of Calgary
Nils Brose
Nils Brose Max Planck Society

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