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William S. Trimble

William S. Trimble

D-Index & Metrics

Biology and Biochemistry

D-Index
77
Citations
16751
World Ranking
4887
National Ranking
174

Research.com Recognitions

  • 2006 - Fellow of the Royal Society of Canada Academy of Science

Overview

William S. Trimble is affiliated with the University of Toronto in Canada and has contributed extensively to the fields of Biochemistry, Genetics, and Molecular Biology. Their research spans multiple subfields, including Molecular Biology, Genetics, Cell Biology, Biomedical Engineering, and Food Science.

Their research topics cover a variety of areas such as Genetic and Kidney Cyst Diseases, Microtubule and mitosis dynamics, Fungal and yeast genetics research, Biofuel production and bioconversion, Hedgehog Signaling Pathway Studies, Epigenetics and DNA Methylation, and Protist diversity and phylogeny.

Recent publications by William S. Trimble include the following:

  • Revised subunit order of mammalian septin complexes explains their in vitro polymerization properties, 2020, Molecular Biology of the Cell
  • A non-canonical Hedgehog pathway initiates ciliogenesis and autophagy, 2020, The Journal of Cell Biology
  • The complex web of canonical and non-canonical Hedgehog signaling, 2022, BioEssays
  • Septin-mediated RhoA activation engages the exocyst complex to recruit the cilium transition zone, 2023, The Journal of Cell Biology
  • DIAPH1 regulates ciliogenesis and trafficking in primary cilia, 2020, The FASEB Journal

William S. Trimble has collaborated frequently with several co-authors, including Oliva Palander, Richard F. Collins, Hong Xie, Moshe S. Kim, and Rachel Shannon.

Their work has appeared primarily in The Journal of Cell Biology, where they have published three papers. Other frequent publication venues include Molecular Biology of the Cell, BioEssays, The FASEB Journal, and the Journal of Biological Chemistry.

William S. Trimble was recognized as a Fellow of the Royal Society of Canada in 2006, an award associated with the Academy of Science.

Best Publications

  • Activation of Synaptic NMDA Receptors Induces Membrane Insertion of New AMPA Receptors and LTP in Cultured Hippocampal Neurons

    Wei-Yang Lu;Heng-Ye Man;William Ju;William S. Trimble

  • VAMP-1: a synaptic vesicle-associated integral membrane protein

    William S. Trimble;David M. Cowan;Richard H. Scheller

  • The septin CDCrel-1 binds syntaxin and inhibits exocytosis.

    Crestina L. Beites;Hong Xie;Robert Bowser;William S. Trimble

  • Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase.

    Otilia V. Vieira;Cecilia Bucci;Rene E. Harrison;William S. Trimble

  • Focal exocytosis of VAMP3-containing vesicles at sites of phagosome formation.

    Lydia Bajno;Xiao-Rong Peng;Alan D. Schreiber;Hsiao-Ping Moore

  • Two Vesicle-associated Membrane Protein Genes Are Differentially Expressed in the Rat Central Nervous System

    Lisa Elferink;W. S. Trimble;R. H. Scheller

  • Members of the VAMP family of synaptic vesicle proteins are components of glucose transporter-containing vesicles from rat adipocytes.

    C. Corley Cain;W. S. Trimble;G. E. Lienhard

  • Phosphatidylinositol polyphosphate binding to the mammalian septin H5 is modulated by GTP.

    Jianshe Zhang;Chen Kong;Hong Xie;Peter S. McPherson

  • Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella.

    Mauricio R. Terebiznik;Otilia V. Vieira;Sandra L. Marcus;Andrea Slade

  • Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36

    Dante Neculai;Michael Schwake;Michael Schwake;Mani Ravichandran;Friederike Zunke

  • The Mammalian Septin MSF Localizes with Microtubules and Is Required for Completion of Cytokinesis

    Mark C. Surka;Christopher W. Tsang;William S. Trimble

  • Cytoskeletal Control of CD36 Diffusion Promotes Its Receptor and Signaling Function

    Khuloud Jaqaman;Hirotaka Kuwata;Nicolas Touret;Richard Collins

  • Botulinum G neurotoxin cleaves VAMP/synaptobrevin at a single Ala-Ala peptide bond.

    G Schiavo;C Malizio;W S Trimble;P Polverino de Laureto

  • Characterization of SNARE protein expression in beta cell lines and pancreatic islets.

    M B Wheeler;L Sheu;M Ghai;A Bouquillon

  • VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis.

    Rong Hua;Derrick Cheng;Étienne Coyaud;Spencer Freeman

  • Distinct roles of septins in cytokinesis: SEPT9 mediates midbody abscission

    Mathew P. Estey;Caterina Di Ciano-Oliveira;Carol D. Froese;Margaret T. Bejide

  • Mammalian SEPT2 Is Required for Scaffolding Nonmuscle Myosin II and Its Kinases

    Emily Joo;Mark C. Surka;William S. Trimble

  • Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

    Anna Y. Lee;Robert P. St.Onge;Michael J. Proctor;Iain M. Wallace

  • Barriers to the free diffusion of proteins and lipids in the plasma membrane.

    William S. Trimble;Sergio Grinstein;Sergio Grinstein

  • Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

    A. Y. Lee;R. P. St.Onge;M. J. Proctor;I. M. Wallace

Frequent Co-Authors

Herbert Y. Gaisano
Herbert Y. Gaisano University of Toronto
Amira Klip
Amira Klip University of Toronto
Richard F. Collins
Richard F. Collins University of Manchester
Alan D. Schreiber
Alan D. Schreiber University of Pennsylvania
Guri Giaever
Guri Giaever University of British Columbia
Corey Nislow
Corey Nislow University of British Columbia
Gaudenz Danuser
Gaudenz Danuser The University of Texas Southwestern Medical Center
Marc Boutry
Marc Boutry Université Catholique de Louvain
Ronald W. Davis
Ronald W. Davis Stanford University

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