George G. Holz

Overview

Best Publications

• In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion

  Andreea Ianus;George G. Holz;Neil D. Theise;Mehboob A. Hussain

  1055
  Citations

• GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels.

  George G. Holz;Stanley G. Rane;Kathleen Dunlap

  802
  Citations

• Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37)

  George G. Holz;Willem M. Kühtreiber;Joel F. Habener

  793
  Citations

• Leptin Suppression of Insulin Secretion by the Activation of ATP-Sensitive K + Channels in Pancreatic β-Cells

  Timothy J. Kieffer;R. Scott Heller;Colin A. Leech;George G. Holz

  728
  Citations

• Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus.

  Jochen Seufert;Timothy J. Kieffer;Colin A. Leech;George G. Holz

  518
  Citations

• Epac: A New cAMP-Binding Protein in Support of Glucagon-Like Peptide-1 Receptor-Mediated Signal Transduction in the Pancreatic β-Cell

  George G. Holz

  502
  Citations

• Epac-selective cAMP Analog 8-pCPT-2′-O-Me-cAMP as a Stimulus for Ca2+-induced Ca2+ Release and Exocytosis in Pancreatic β-Cells

  Guoxin Kang;Jamie W. Joseph;Oleg G. Chepurny;Marie Monaco

  389
  Citations

• cAMP-dependent Mobilization of Intracellular Ca2+ Stores by Activation of Ryanodine Receptors in Pancreatic β-Cells A Ca2+ SIGNALING SYSTEM STIMULATED BY THE INSULINOTROPIC HORMONE GLUCAGON-LIKE PEPTIDE-1-(7–37)

  George G. Holz;Colin A. Leech;Colin A. Leech;R. Scott Heller;R. Scott Heller;Maurice Castonguay;Maurice Castonguay

  324
  Citations

• Cell physiology of cAMP sensor Epac

  George G. Holz;Guoxin Kang;Mark Harbeck;Michael W. Roe

  322
  Citations

• Regulation of Glucose Homeostasis by GLP-1

  Prashant Nadkarni;Oleg G. Chepurny;George G. Holz

  303
  Citations

• Activation of a cAMP-regulated Ca2+-Signaling Pathway in Pancreatic β-Cells by the Insulinotropic Hormone Glucagon-like Peptide-1

  George G. Holz;Colin A. Leech;Joel F. Habener

  250
  Citations

• cAMP‐regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+‐induced Ca2+ release in INS‐1 pancreatic β‐cells

  Guoxin Kang;Oleg G. Chepurny;George G. Holz

  247
  Citations

• Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells.

  Takashi Tsuboi;Gabriela da Silva Xavier;George G. Holz;Laurence S. Jouaville

  239
  Citations

• Interplay of Ca2+ and cAMP Signaling in the Insulin-secreting MIN6 β-Cell Line

  Luis R. Landa;Mark Harbeck;Kelly Kaihara;Oleg Chepurny

  225
  Citations

• G proteins as regulators of ion channel function.

  Kathleen Dunlap;George G. Holz;Stanley G. Rane

  220
  Citations

• Dihydropyridine inhibition of neuronal calcium current and substance P release.

  Stanley G. Rane;George G. Holz;Kathleen Dunlap

  220
  Citations

• Glucagon-like peptide-1 synthetic analogs: New therapeutic agents for use in the treatment of diabetes mellitus

  George G. Holz;Oleg G. Chepurny

  200
  Citations

• The polyunsaturated fatty acids of marine dinoflagellates.

  Glenn W. Harrington;David H. Beach;Joyce E. Dunham;George G. Holz

  189
  Citations

• Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors.

  George G. Holz;Oleg G. Chepurny;Frank Schwede

  187
  Citations

• Role of phospholipase Cε in physiological phosphoinositide signaling networks.

  Alan V. Smrcka;Joan Heller Brown;George G. Holz

  185
  Citations