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Biology and Biochemistry

D-Index
78
Citations
24891
World Ranking
4500
National Ranking
152

Medicine

D-Index
78
Citations
24907
World Ranking
17965
National Ranking
753

Overview

Timothy J. Kieffer is affiliated with the University of British Columbia in Canada. Their research focuses primarily on Medicine, with a significant number of publications in Biochemistry, Genetics, and Molecular Biology. The main subfields of study include Surgery, Molecular Biology, Endocrinology, Diabetes and Metabolism, Genetics, and Physiology.

The primary research topics covered by Timothy J. Kieffer involve pancreatic function and diabetes, diabetes management and research, diabetes and associated disorders, pluripotent stem cells research, 3D printing in biomedical research, adipokines, inflammation, and metabolic diseases, as well as diabetes treatment and management.

The recent publications include:

  • Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes, 2021, Cell stem cell
  • Tissue-Specific Effects of Leptin on Glucose and Lipid Metabolism, 2020, Endocrine Reviews
  • Encapsulated stem cell-derived β cells exert glucose control in patients with type 1 diabetes, 2023, Nature Biotechnology
  • Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2, 2020, Diabetes
  • Human Pluripotent Stem Cells to Model Islet Defects in Diabetes, 2021, Frontiers in Endocrinology

Frequent co-authors collaborating with Timothy J. Kieffer include:

  • Robert K. Baker
  • Cara E. Ellis
  • Diepiriye G. Iworima
  • Adam Ramzy
  • Shenghui Liang

Timothy J. Kieffer has published extensively in scientific journals, with the most frequent publication venues being Diabetes, Scientific Reports, Transplantation, Cell stem cell, and Endocrine Reviews.

Best Publications

  • Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

    Alireza Rezania;Jennifer E Bruin;Payal Arora;Allison Rubin

  • Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV

    T. J. Kieffer;C. H. S. Mcintosh;R. A. Pederson

  • The glucagon-like peptides.

    Timothy James Kieffer;Joel Francis Habener

  • Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women.

    Karen L Teff;Sharon S Elliott;Matthias Tschöp;Timothy J Kieffer

  • Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

    Doris A. Stoffers;Timothy J. Kieffer;Mehboob A. Hussain;Daniel J. Drucker

  • Leptin Suppression of Insulin Secretion by the Activation of ATP-Sensitive K + Channels in Pancreatic β-Cells

    Timothy J. Kieffer;R. Scott Heller;Colin A. Leech;George G. Holz

  • Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages

    Raewyn M Seaberg;Simon R Smukler;Timothy J Kieffer;Grigori Enikolopov

  • The adipoinsular axis: effects of leptin on pancreatic β-cells

    Timothy J. Kieffer;Joel F. Habener

  • Maturation of Human Embryonic Stem Cell–Derived Pancreatic Progenitors into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

    Alireza Rezania;Jennifer E. Bruin;Michael J. Riedel;Majid Mojibian

  • Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production

    Arya E. Mehran;Nicole M. Templeman;G. Stefano Brigidi;Gareth E. Lim

  • Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus.

    Jochen Seufert;Timothy J. Kieffer;Colin A. Leech;George G. Holz

  • Leptin receptors expressed on pancreatic beta-cells.

    Kieffer Tj;Heller Rs;Habener Jf

  • Glucose-dependent insulin release from genetically engineered K cells.

    Anthony T. Cheung;Bama Dayanandan;Jamie T. Lewis;Gregory S. Korbutt

  • Ghrelin, Peptide YY, Glucose-Dependent Insulinotropic Polypeptide, and Hunger Responses to a Mixed Meal in Anorexic, Obese, and Control Female Adolescents

    Sue Stock;Pierre Leichner;Alfred C. K. Wong;Mohamed A. Ghatei

  • Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice

    Jochen Seufert;Timothy J. Kieffer;Joel F. Habener

  • Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo.

    Alireza Rezania;Jennifer E. Bruin;Jean Xu;Kavitha Narayan

  • Functional GIP Receptors Are Present on Adipocytes

    Rupert G.-C. Yip;Michael O. Boylan;Timothy J. Kieffer;M. Michael Wolfe

  • Defective Glucose-Dependent Insulinotropic Polypeptide Receptor Expression in Diabetic Fatty Zucker Rats

    Francis C. Lynn;Nathalie Pamir;Eddy H.C. Ng;Christopher H.S. McIntosh

  • Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing alpha-cells of the rat endocrine pancreas.

    R S Heller;T J Kieffer;J F Habener

  • Disruption of Hepatic Leptin Signaling Protects Mice from Age- and Diet- Related Glucose Intolerance Running Title: Liver Leptin Signaling and Glucose Tolerance

    Frank K. Huynh;Jasna Levi;Heather C. Denroche;Sarah L. Gray

Frequent Co-Authors

Joel F. Habener
Joel F. Habener Harvard University
Leif Groop
Leif Groop Lund University
Raymond J. Andersen
Raymond J. Andersen University of British Columbia
Allan Vaag
Allan Vaag Steno Diabetes Center
Valeriya Lyssenko
Valeriya Lyssenko University of Bergen
Paul D. Robbins
Paul D. Robbins University of Minnesota
Markku Laakso
Markku Laakso University of Eastern Finland
Ray V. Rajotte
Ray V. Rajotte University of Alberta
Sten Madsbad
Sten Madsbad University of Copenhagen
Peter Rossing
Peter Rossing University of Copenhagen

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