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Molecular Biology

D-Index
118
Citations
85238
World Ranking
274
National Ranking
163

Research.com Recognitions

  • 1996 - Fellow of the Royal Society, United Kingdom

Overview

David Beach is affiliated with Cold Spring Harbor Laboratory in the United States. Their research spans several areas within biomedical sciences, particularly focusing on medicine and biochemistry, genetics, and molecular biology.

The primary fields of study for David Beach include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Significant subfields within these areas of expertise are:

  • Molecular Biology
  • Physiology
  • Pulmonary and Respiratory Medicine
  • Genetics
  • Oncology

The main topics covered in their work are:

  • Epigenetics and DNA Methylation
  • Telomeres, Telomerase, and Senescence
  • Prostate Cancer Treatment and Research
  • Cancer-related gene regulation
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Cancer-related Molecular Pathways
  • Genetic factors in colorectal cancer

The scientist has contributed to various research publications across multiple respected venues. Frequent publication platforms include:

  • UNC Libraries
  • Nature Cell Biology
  • Oncogene
  • Cancer Research
  • arXiv (Cornell University)

Recent papers authored or co-authored by David Beach include:

  • Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation. (2020, UNC Libraries)
  • Author Correction: Polycomb CBX7 has a unifying role in cellular lifespan. (2022, Nature Cell Biology)
  • Retraction Note: CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus. (2022, Oncogene)
  • Editor's Note: Immortalization of Primary Human Prostate Epithelial Cells by c-Myc. (2022, Cancer Research)
  • Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model. (2020, UNC Libraries)

Collaborations have been an integral part of their research, with frequent co-authors including:

  • Jesús Gil
  • David Bernard
  • Dolores Martínez
  • Gordon Peters
  • Amancio Carnero

Of note, David Beach was awarded the distinction of Fellow of the Royal Society, United Kingdom, in 1996.

Best Publications

  • Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

    Manuel Serrano;Athena W Lin;Mila E McCurrach;David Beach;David Beach

  • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

    Manual Serrano;Gregory J. Hannon;David Beach

  • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

    Scott M. Hammond;Emily Bernstein;Emily Bernstein;David Beach;Gregory J. Hannon

  • p21 is a universal inhibitor of cyclin kinases

    Yue Xiong;Gregory J. Hannon;Gregory J. Hannon;Hui Zhang;Hui Zhang;David Casso;David Casso

  • pl5 INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

    Gregory J. Hannon;David Beach

  • The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

    Shou Waga;Gregory J. Hannon;David Beach;Bruce Stillman

  • Tumour biology: Senescence in premalignant tumours

    Manuel Collado;Jesús Gil;Alejo Efeyan;Carmen Guerra

  • Role of the INK4a locus in tumor suppression and cell mortality

    Manuel Serrano;Han Woong Lee;Lynda Chin;Carlos Cordon-Cardo

  • Radiation-induced cell cycle arrest compromised by p21 deficiency

    James B Brugarolas;Chitra Chandrasekaran;Jeffrey I. Gordon;David Beach

  • Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD

    Orna Halevy;Bennett G. Novitch;Douglas B. Spicer;Stephen X. Skapek

  • p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage

    Kay F. Macleod;Nicole Sherry;Greg Hannon;David Beach

  • D Type Cyclins Associate with Multiple Protein Kinases and the DNA Replication and Repair Factor PCNA

    Yue Xiong;Hui Zhang;David Beach

  • Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

    D A Alcorta;Y Xiong;D Phelps;G Hannon

  • The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis

    William G. Dunphy;Leonardo Brizuela;David Beach;John Newport

  • Targeting CDK4 and CDK6: From Discovery to Therapy

    Charles J. Sherr;David Beach;Geoffrey I. Shapiro

  • Cdc25 cell-cycle phosphatase as a target of c- myc

    Konstantin Galaktionov;Xiaocun Chen;David Beach

  • Human D-type cyclin

    Yue Xiong;Tim Connolly;Bruce Futcher;David Beach

  • Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

    Giulio Draetta;David Beach

  • Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator

    Neil D. Perkins;Lisa K. Felzien;Jonathan C. Betts;Kwanyee Leung

  • p21-containing cyclin kinases exist in both active and inactive states.

    Hui Zhang;G. J. Hannon;D. Beach

Frequent Co-Authors

Gregory J. Hannon
Gregory J. Hannon University of Cambridge
Manuel Serrano
Manuel Serrano Institució Catalana de Recerca i Estudis Avançats
George G. Holz
George G. Holz SUNY Upstate Medical University
Giulio Draetta
Giulio Draetta The University of Texas MD Anderson Cancer Center
Yue Xiong
Yue Xiong University of North Carolina at Chapel Hill
Amancio Carnero
Amancio Carnero Spanish National Research Council
Jesús Gil
Jesús Gil Imperial College London
Catherine E. Costello
Catherine E. Costello Boston University
Bruce Stillman
Bruce Stillman Cold Spring Harbor Laboratory
Gordon Peters
Gordon Peters Cancer Research UK London Research Institute

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