His main research concerns Cell biology, Rap1, Signal transduction, Guanine nucleotide exchange factor and Biochemistry. His Cell biology study often links to related topics such as Cell junction. His Rap1 study which covers Cell adhesion that intersects with Cell adhesion molecule, Fibronectin and Integrin.
His work carried out in the field of Signal transduction brings together such families of science as Platelet, GTP' and Platelet-derived growth factor receptor. Johannes L. Bos has included themes like Protein structure, GTP-binding protein regulators, Small G Protein and Second messenger system in his Guanine nucleotide exchange factor study. His GTP-binding protein regulators research focuses on Prostaglandin and how it relates to Molecular biology.
Johannes L. Bos mostly deals with Cell biology, Rap1, Signal transduction, Guanine nucleotide exchange factor and Biochemistry. His Cell biology research is multidisciplinary, relying on both Cell adhesion and Actin cytoskeleton. His Cell adhesion research is multidisciplinary, incorporating elements of Integrin and Cell adhesion molecule.
He combines subjects such as Cadherin, Adherens junction, GTP-binding protein regulators, Diacylglycerol kinase and Ionomycin with his study of Rap1. His Signal transduction research includes elements of Molecular biology, Endocrinology, Internal medicine and Platelet-derived growth factor receptor. His studies in Guanine nucleotide exchange factor integrate themes in fields like Pleckstrin homology domain, CAMP binding, Protein kinase A, Second messenger system and Protein structure.
Johannes L. Bos focuses on Cell biology, Rap1, Signal transduction, Guanine nucleotide exchange factor and Apical membrane. The study incorporates disciplines such as Cell adhesion and Actin cytoskeleton in addition to Cell biology. His studies deal with areas such as Motility, Cytoskeleton, Actin, Adherens junction and Effector as well as Rap1.
His research integrates issues of EGFR inhibitors and Kinase, Protein kinase A in his study of Signal transduction. Guanine nucleotide exchange factor is closely attributed to Second messenger system in his research. His work deals with themes such as Endosome and Cell polarity, which intersect with Apical membrane.
Cell biology, Small G Protein, Genetics, Actin and Rap1 are his primary areas of study. In general Cell biology study, his work on Pleckstrin homology domain often relates to the realm of Microvillus, thereby connecting several areas of interest. His Small G Protein study frequently links to related topics such as Intracellular.
His Genetics research includes themes of Physical interaction and Enzyme. The Actin study combines topics in areas such as GTPase-activating protein, Signal transduction, Small GTPase, Stress fiber and Motility. His Rap1 research incorporates elements of HEK 293 cells, Adherens junction, Live cell imaging and Signal transducing adaptor protein.
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Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
J. de Rooij;F. J. T. Zwartkruis;M. H. G. Verheijen;R. H. Cool.
GEFs and GAPs: Critical Elements in the Control of Small G Proteins
Johannes L. Bos;Holger Rehmann;Alfred Wittinghofer.
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.
René H. Medema;Geert J. P. L. Kops;Johannes L. Bos;Boudewijn M. T. Burgering.
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
Geert J. P. L. Kops;Tobias B. Dansen;Paulien E. Polderman;Ingrid Saarloos.
Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2
Attila Garami;Fried J.T Zwartkruis;Takahiro Nobukuni;Manel Joaquin.
Molecular Cell (2003)
Direct control of the Forkhead transcription factor AFX by protein kinase B
Kops Gj;de Ruiter Nd;De Vries-Smits Am;Powell Dr.
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
Takahiro Nobukuni;Manel Joaquin;Manel Joaquin;Marta Roccio;Stephen G. Dann.
Proceedings of the National Academy of Sciences of the United States of America (2005)
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.
Marieke A G Essers;Sanne Weijzen;Alida M M de Vries-Smits;Ingrid Saarloos.
The EMBO Journal (2004)
Rap1 signalling: adhering to new models
J L Bos;J de Rooij;K A Reedquist.
Nature Reviews Molecular Cell Biology (2001)
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.
Jorrit M. Enserink;Anne E. Christensen;Johan de Rooij;Miranda van Triest.
Nature Cell Biology (2002)
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