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Biology and Biochemistry
Netherlands
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
107
Citations
52459
World Ranking
1084
National Ranking
13

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award

Overview

Johannes L. Bos is affiliated with Utrecht University in the Netherlands. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on Oncology, Cell Biology, and Pulmonary and Respiratory Medicine.

The scientist's work extensively covers topics related to cancer cells and metastasis, cellular mechanics and interactions, and molecular mechanisms underlying cancer pathways. Specific research interests include melanoma and MAPK pathways, cancer genomics and diagnostics, gastric cancer management and outcomes, esophageal cancer research and treatment, and lung cancer treatments and mutations.

Publications by Johannes L. Bos demonstrate involvement in both experimental and translational cancer research. Notable recent papers include:

  • "Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling" (2021, Nature Cell Biology)
  • "Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer" (2023, Cell Reports)
  • "P02.07 Trial in progress: anti-PD1, capecitabine, and oxaliplatin for the first-line treatment of dMMR esophagogastric cancer (AuspiCiOus-dMMR): a proof-of-principle study (AuspiCiOus)" (2024, Poster presentations)
  • "Drug Repurposing Screen on Patient-Derived Organoids Identifies New Therapeutic Drug Combination Against KRAS Mutant Colon Cancer" (2021, SSRN Electronic Journal)

Frequent co-authorship indicates collaboration with researchers such as Bas Ponsioen, Sander Mertens, Sylvia F. Boj, Hugo J.G. Snippert, and Maarten A. Huismans, each contributing to multiple publications alongside Bos.

Their research has been published in venues including Nature Cell Biology, Cell Reports, Poster presentations, and SSRN Electronic Journal, reflecting a range of formats from high-impact journals to conference posters.

Best Publications

  • Prevalence of ras gene mutations in human colorectal cancers

    Johannes L. Bos;Matty Verlaan de Vries;Alex J. Van Der Eb;Eric R. Fearon

  • Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

    J. de Rooij;F. J. T. Zwartkruis;M. H. G. Verheijen;R. H. Cool

  • GEFs and GAPs: Critical Elements in the Control of Small G Proteins

    Johannes L. Bos;Holger Rehmann;Alfred Wittinghofer

  • Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

    Geert J. P. L. Kops;Tobias B. Dansen;Paulien E. Polderman;Ingrid Saarloos

  • AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.

    René H. Medema;Geert J. P. L. Kops;Johannes L. Bos;Boudewijn M. T. Burgering

  • Direct control of the Forkhead transcription factor AFX by protein kinase B

    Kops Gj;de Ruiter Nd;De Vries-Smits Am;Powell Dr

  • Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

    Attila Garami;Fried J.T Zwartkruis;Takahiro Nobukuni;Manel Joaquin

  • K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung.

    Slebos Rj;Kibbelaar Re;Dalesio O;Kooistra A

  • Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

    Takahiro Nobukuni;Manel Joaquin;Manel Joaquin;Marta Roccio;Stephen G. Dann

  • FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.

    Marieke A G Essers;Sanne Weijzen;Alida M M de Vries-Smits;Ingrid Saarloos

  • Rap1 signalling: adhering to new models

    J L Bos;J de Rooij;K A Reedquist

  • A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

    Jorrit M. Enserink;Anne E. Christensen;Johan de Rooij;Miranda van Triest

  • Epac proteins: multi-purpose cAMP targets.

    Johannes L. Bos

  • Epac: a new cAMP target and new avenues in cAMP research

    Johannes L. Bos

  • Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras

    J de Rooij;J L Bos

  • Linking Rap to cell adhesion.

    Johannes L Bos

  • An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

    Oded Kopper;Chris J de Witte;Kadi Lõhmussaar;Jose Espejo Valle-Inclan

  • Epac: Defining a New Mechanism for cAMP Action

    Martijn Gloerich;Johannes L. Bos

  • Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator.

    Bas Ponsioen;Jun Zhao;Jurgen Riedl;Fried Zwartkruis

  • Involvement of p21ras in activation of extracellular signal-regulated kinase 2

    Alida M. M. de Vries-Smits;Boudewijn M. Th. Burgering;Sally J. Leevers;Christopher J. Mar shall

Frequent Co-Authors

Fried J. T. Zwartkruis
Fried J. T. Zwartkruis Utrecht University
Holger Rehmann
Holger Rehmann Utrecht University
Boudewijn M. T. Burgering
Boudewijn M. T. Burgering Utrecht University
Barbara Franke
Barbara Franke Radboud University
René H. Medema
René H. Medema Princess Máxima Center
Alfred Wittinghofer
Alfred Wittinghofer Max Planck Society
Stein Ove Døskeland
Stein Ove Døskeland University of Bergen
Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Leo Koenderman
Leo Koenderman Utrecht University
René Bernards
René Bernards Antoni van Leeuwenhoek Hospital

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