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Biology and Biochemistry
Netherlands
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
107
Citations
52459
World Ranking
1084
National Ranking
13

Johannes L. Bos publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Johannes L. Bos sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 251 publications — 67th percentile

67% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Johannes L. Bos D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Johannes L. Bos sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 107 D-Index — 95th percentile

95% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award

Overview

Johannes L. Bos is affiliated with Utrecht University in the Netherlands. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on Oncology, Cell Biology, and Pulmonary and Respiratory Medicine.

The scientist's work extensively covers topics related to cancer cells and metastasis, cellular mechanics and interactions, and molecular mechanisms underlying cancer pathways. Specific research interests include melanoma and MAPK pathways, cancer genomics and diagnostics, gastric cancer management and outcomes, esophageal cancer research and treatment, and lung cancer treatments and mutations.

Publications by Johannes L. Bos demonstrate involvement in both experimental and translational cancer research. Notable recent papers include:

  • "Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling" (2021, Nature Cell Biology)
  • "Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer" (2023, Cell Reports)
  • "P02.07 Trial in progress: anti-PD1, capecitabine, and oxaliplatin for the first-line treatment of dMMR esophagogastric cancer (AuspiCiOus-dMMR): a proof-of-principle study (AuspiCiOus)" (2024, Poster presentations)
  • "Drug Repurposing Screen on Patient-Derived Organoids Identifies New Therapeutic Drug Combination Against KRAS Mutant Colon Cancer" (2021, SSRN Electronic Journal)

Frequent co-authorship indicates collaboration with researchers such as Bas Ponsioen, Sander Mertens, Sylvia F. Boj, Hugo J.G. Snippert, and Maarten A. Huismans, each contributing to multiple publications alongside Bos.

Their research has been published in venues including Nature Cell Biology, Cell Reports, Poster presentations, and SSRN Electronic Journal, reflecting a range of formats from high-impact journals to conference posters.

Best Publications

  • Prevalence of ras gene mutations in human colorectal cancers

    Johannes L. Bos;Matty Verlaan de Vries;Alex J. Van Der Eb;Eric R. Fearon

  • Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

    J. de Rooij;F. J. T. Zwartkruis;M. H. G. Verheijen;R. H. Cool

  • GEFs and GAPs: Critical Elements in the Control of Small G Proteins

    Johannes L. Bos;Holger Rehmann;Alfred Wittinghofer

  • Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

    Geert J. P. L. Kops;Tobias B. Dansen;Paulien E. Polderman;Ingrid Saarloos

  • AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.

    René H. Medema;Geert J. P. L. Kops;Johannes L. Bos;Boudewijn M. T. Burgering

  • Direct control of the Forkhead transcription factor AFX by protein kinase B

    Kops Gj;de Ruiter Nd;De Vries-Smits Am;Powell Dr

  • Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

    Attila Garami;Fried J.T Zwartkruis;Takahiro Nobukuni;Manel Joaquin

  • K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung.

    Slebos Rj;Kibbelaar Re;Dalesio O;Kooistra A

  • Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

    Takahiro Nobukuni;Manel Joaquin;Manel Joaquin;Marta Roccio;Stephen G. Dann

  • FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.

    Marieke A G Essers;Sanne Weijzen;Alida M M de Vries-Smits;Ingrid Saarloos

  • Rap1 signalling: adhering to new models

    J L Bos;J de Rooij;K A Reedquist

  • A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.

    Jorrit M. Enserink;Anne E. Christensen;Johan de Rooij;Miranda van Triest

  • Epac proteins: multi-purpose cAMP targets.

    Johannes L. Bos

  • Epac: a new cAMP target and new avenues in cAMP research

    Johannes L. Bos

  • Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras

    J de Rooij;J L Bos

  • Linking Rap to cell adhesion.

    Johannes L Bos

  • An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

    Oded Kopper;Chris J de Witte;Kadi Lõhmussaar;Jose Espejo Valle-Inclan

  • Epac: Defining a New Mechanism for cAMP Action

    Martijn Gloerich;Johannes L. Bos

  • Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator.

    Bas Ponsioen;Jun Zhao;Jurgen Riedl;Fried Zwartkruis

  • Involvement of p21ras in activation of extracellular signal-regulated kinase 2

    Alida M. M. de Vries-Smits;Boudewijn M. Th. Burgering;Sally J. Leevers;Christopher J. Mar shall

Frequent Co-Authors

Fried J. T. Zwartkruis
Fried J. T. Zwartkruis Utrecht University
Holger Rehmann
Holger Rehmann Utrecht University
Boudewijn M. T. Burgering
Boudewijn M. T. Burgering Utrecht University
Barbara Franke
Barbara Franke Radboud University
René H. Medema
René H. Medema Princess Máxima Center
Alfred Wittinghofer
Alfred Wittinghofer Max Planck Society
Stein Ove Døskeland
Stein Ove Døskeland University of Bergen
Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Leo Koenderman
Leo Koenderman Utrecht University
René Bernards
René Bernards Antoni van Leeuwenhoek Hospital

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