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Fried J. T. Zwartkruis

Fried J. T. Zwartkruis

D-Index & Metrics

Molecular Biology

D-Index
50
Citations
15980
World Ranking
2532
National Ranking
61

Overview

Fried J. T. Zwartkruis is affiliated with Utrecht University in the Netherlands. Their research portfolio spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with a strong emphasis on molecular and cellular processes relevant to human health and disease.

Their recent published papers include:

  • "mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy," 2021, Journal of the American Society of Nephrology
  • "Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1-dependent TFEB/TFE3 regulation," 2021, EMBO Molecular Medicine
  • "The malate-aspartate shuttle is important for de novo serine biosynthesis," 2023, Cell Reports
  • "A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion," 2024, Nature Communications
  • "Upregulation of the pathogenic transcription factor SPI1/PU.1 in tuberous sclerosis complex and focal cortical dysplasia by oxidative stress," 2021, Brain Pathology

Their research areas cover a range of topics related to metabolism, cellular function, and disease mechanisms. The main topics of their work include:

  • Metabolism and Genetic Disorders
  • Renal and related cancers
  • Renal Diseases and Glomerulopathies
  • Ion Transport and Channel Regulation
  • Biomedical Research and Pathophysiology
  • Mitochondrial Function and Pathology
  • Cellular transport and secretion

Zwartkruis's work is situated primarily within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. They have a significant number of publications in specific subfields such as Molecular Biology, Physiology, Cell Biology, Clinical Biochemistry, and Nephrology.

Frequent collaborators include:

  • Denise Westland
  • Nanda M. Verhoeven-Duif
  • Judith Jans
  • Susan Zwakenberg
  • Johan Gerrits

Their studies are often published in scientific journals including:

  • Metabolites
  • Journal of the American Society of Nephrology
  • Cell Reports
  • Nature Communications
  • EMBO Molecular Medicine

Best Publications

  • Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

    J. de Rooij;F. J. T. Zwartkruis;M. H. G. Verheijen;R. H. Cool

  • A genetic screen for mutations affecting embryogenesis in zebrafish

    Wolfgang Driever;Lilianna Solnica-Krezel;Alexander F. Schier;Stephan C.F. Neuhauss

  • Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

    Attila Garami;Fried J.T Zwartkruis;Takahiro Nobukuni;Manel Joaquin

  • Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

    Takahiro Nobukuni;Manel Joaquin;Manel Joaquin;Marta Roccio;Stephen G. Dann

  • Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo.

    Didier Y.R. Stainier;Bernadette Fouquet;Jau Nian Chen;Kerri S. Warren

  • Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator.

    Bas Ponsioen;Jun Zhao;Jurgen Riedl;Fried Zwartkruis

  • Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function

    Iain A. Drummond;Arindam Majumdar;Hartmut Hentschel;Marlies Elger

  • The Small Gtpase, Rap1, Mediates Cd31-Induced Integrin Adhesion

    Kris Reedquist;Ewan Ross;EA Koop;RM Wolthuis

  • Mutations affecting the development of the embryonic zebrafish brain

    Alexander F. Schier;Stephan C.F. Neuhauss;Michele Harvey;Jarema Malicki

  • Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish

    L. Solnica-Krezel;D. L. Stemple;E. Mountcastle-Shah;Z. Rangini

  • Mutations affecting development of the zebrafish retina

    Jarema Malicki;Stephan C.F. Neuhauss;Alexander F. Schier;Lilianna Solnica-Krezel

  • CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation

    Silvia De Rubeis;Emanuela Pasciuto;Ka Wan Li;Esperanza Fernández

  • Mutations affecting craniofacial development in zebrafish.

    Stephan C.F. Neuhauss;Lilianna Solnica-Krezel;Alexander F. Schier;Fried Zwartkruis

  • Rap1 Regulates E-cadherin-mediated Cell-Cell Adhesion

    Leo S. Price;Amra Hajdo-Milasinovic;Jun Zhao;Fried J.T. Zwartkruis

  • Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling.

    Fried J.T. Zwartkruis;Rob M.F. Wolthuis;Nicolle M.J.M. Nabben;Barbara Franke

  • The role of Rap1 in integrin-mediated cell adhesion.

    J.L. Bos;K. de Bruyn;J. Enserink;B. Kuiperij

  • Hematopoietic mutations in the zebrafish

    Brant M. Weinstein;Alexander F. Schier;Salim Abdelilah;Jarema Malicki

  • Ras and Rap1: Two Highly Related Small GTPases with Distinct Function

    Fried J.T. Zwartkruis;Johannes L. Bos

  • Mutations affecting development of the notochord in zebrafish.

    Derek L. Stemple;Lilianna Solnica-Krezel;Fried Zwartkruis;Stephan C.F. Neuhauss

  • Cell-cell junction formation: The role of Rap1 and Rap1 guanine nucleotide exchange factors

    Willem-Jan Pannekoek;Matthijs R.H. Kooistra;Fried J.T. Zwartkruis;Johannes L. Bos

Frequent Co-Authors

Johannes L. Bos
Johannes L. Bos Utrecht University
Wolfgang Driever
Wolfgang Driever University of Freiburg
Stephan C.F. Neuhauss
Stephan C.F. Neuhauss University of Zurich
Derek L. Stemple
Derek L. Stemple Camena Bioscience
Jarema Malicki
Jarema Malicki University of Sheffield
Lilianna Solnica-Krezel
Lilianna Solnica-Krezel Washington University in St. Louis
Alexander F. Schier
Alexander F. Schier University of Basel
Didier Y. R. Stainier
Didier Y. R. Stainier Max Planck Society
Holger Rehmann
Holger Rehmann Utrecht University
Barbara Franke
Barbara Franke Radboud University

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