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Biology and Biochemistry

D-Index
49
Citations
11955
World Ranking
17890
National Ranking
433

Overview

Holger Rehmann is affiliated with Utrecht University in the Netherlands and conducts research primarily in the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine. Their scientific contributions span several subfields, including Molecular Biology, Oncology, Cell Biology, Cancer Research, and Pathology and Forensic Medicine.

Their recent publications highlight a focus on cellular signaling pathways, cancer biology, and genetic disorders. Notable papers include:

  • Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling, 2021, Nature Cell Biology
  • Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns, 2021, Nature Genetics
  • mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy, 2021, Journal of the American Society of Nephrology
  • Treatment of ARS deficiencies with specific amino acids, 2021, Genetics in Medicine
  • NAA80 bi-allelic missense variants result in high-frequency hearing loss, muscle weakness and developmental delay, 2021, Brain Communications

Rehmann's research covers key topics such as:

  • Cellular Mechanics and Interactions
  • Cancer Genomics and Diagnostics
  • Cancer Cells and Metastasis
  • Ion Transport and Channel Regulation
  • Biomedical Research and Pathophysiology
  • Peptidase Inhibition and Analysis
  • Cell Adhesion Molecules Research

Frequent coauthors in Rehmann's research include Susanne M.A. Lens, Sabine A. Fuchs, Irena Muffels, Bas Ponsioen, and Hugo J.G. Snippert. The main venues of publication include Nature Cell Biology, Nature Genetics, Journal of the American Society of Nephrology, Genetics in Medicine, and Brain Communications.

Their work is characterized by investigations into molecular mechanisms underlying cancer progression, genetic mutations affecting organ function, and treatment approaches for genetic disorders. Rehmann's involvement in both fundamental and translational research integrates cellular and molecular insights with clinical relevance.

Best Publications

  • GEFs and GAPs: Critical Elements in the Control of Small G Proteins

    Johannes L. Bos;Holger Rehmann;Alfred Wittinghofer

  • Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

    Sung Jun Park;Faiyaz Ahmad;Andrew Philp;Keith Baar

  • Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.

    J. de Rooij;H. Rehmann;H. Rehmann;M. van Triest;R. H. Cool

  • Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling

    Stephan Huveneers;Joppe Oldenburg;Emma Spanjaard;Gerard van der Krogt

  • A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase.

    Martina Schmidt;Sandrine Evellin;Paschal A. Oude Weernink;Frank vom Dorp

  • Efficient Intracellular Delivery of Native Proteins

    Diego S D'Astolfo;Romina J Pagliero;Anita Pras;Wouter R Karthaus

  • Cyclic nucleotide analogs as probes of signaling pathways.

    Heiko Poppe;Heiko Poppe;Sergei D. Rybalkin;Holger Rehmann;Thomas R. Hinds

  • Capturing cyclic nucleotides in action: snapshots from crystallographic studies.

    Holger Rehmann;Alfred Wittinghofer;Johannes L. Bos

  • The role of Rap1 in integrin-mediated cell adhesion.

    J.L. Bos;K. de Bruyn;J. Enserink;B. Kuiperij

  • Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state

    Holger Rehmann;Joost Das;Puck Knipscheer;Alfred Wittinghofer

  • Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

    Holger Rehmann;Ernesto Arias-Palomo;Michael A. Hadders;Frank Schwede

  • Structure and regulation of the cAMP-binding domains of Epac2.

    Holger Rehmann;Balaji Prakash;Eva Wolf;Alma Rueppel

  • Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac.

    Holger Rehmann;Frank Schwede;Stein O. Døskeland;Alfred Wittinghofer

  • cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic β cells and rat INS-1 cells

    Guoxin Kang;Oleg G. Chepurny;Brian Malester;Michael J. Rindler

  • Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3.

    Hugo van Ingen;Frederik M.A. van Schaik;Hans Wienk;Joost Ballering

  • Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation

    Floor Twiss;Quint Le Duc;Suzanne Van Der Horst;Hamid Tabdili

  • A Novel Cyclic AMP-Dependent Epac-Rit Signaling Pathway Contributes to PACAP38-Mediated Neuronal Differentiation

    Geng-Xian Shi;Holger Rehmann;Douglas A. Andres

  • 8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue.

    Marjolein J. Vliem;Bas Ponsioen;Frank Schwede;Willem-Jan Pannekoek

  • Neuron Specific Rab4 Effector GRASP-1 Coordinates Membrane Specialization and Maturation of Recycling Endosomes

    Casper C. Hoogenraad;Ioana Popa;Kensuke Futai;Emma Sanchez-Martinez

  • Direct Spatial Control of Epac1 by Cyclic AMP

    Bas Ponsioen;Martijn Gloerich;Laila Ritsma;Laila Ritsma;Holger Rehmann

Frequent Co-Authors

Johannes L. Bos
Johannes L. Bos Utrecht University
Fried J. T. Zwartkruis
Fried J. T. Zwartkruis Utrecht University
Alfred Wittinghofer
Alfred Wittinghofer Max Planck Society
Boudewijn M. T. Burgering
Boudewijn M. T. Burgering Utrecht University
Peter J.M. van Haastert
Peter J.M. van Haastert University of Groningen
Kees Jalink
Kees Jalink Antoni van Leeuwenhoek Hospital
Judith Klumperman
Judith Klumperman Utrecht University
Christophe Erneux
Christophe Erneux Université Libre de Bruxelles
Viola Oorschot
Viola Oorschot Utrecht University
Slavé Petrovski
Slavé Petrovski AstraZeneca (United Kingdom)

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