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D-Index & Metrics

Molecular Biology

D-Index
73
Citations
20117
World Ranking
1272
National Ranking
33

Overview

Alpha S. Yap is affiliated with the University of Queensland in Australia and has made contributions primarily in the field of Biochemistry, Genetics and Molecular Biology, with a focus on Cell Biology, Molecular Biology, Biomedical Engineering, Immunology, and Physiology.

The scientist's research covers several main topics, including:

  • Cellular Mechanics and Interactions
  • Microtubule and mitosis dynamics
  • 3D Printing in Biomedical Research
  • Hippo pathway signaling and YAP/TAZ
  • Cell Adhesion Molecules Research
  • Erythrocyte Function and Pathophysiology
  • Skin and Cellular Biology Research

Alpha S. Yap has published studies in a variety of venues, with frequent publications in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Current Biology
  • Molecular Biology of the Cell
  • Developmental Cell

Recent notable papers include:

  • Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers, 2021, Nature Materials
  • Adherens junctions as molecular regulators of emergent tissue mechanics, 2023, Nature Reviews Molecular Cell Biology
  • Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusion, 2021, Current Biology
  • Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells, 2020, Developmental Cell
  • Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies, 2020, Proceedings of the National Academy of Sciences

The scientist has worked frequently with several coauthors, including:

  • Ivar Noordstra
  • Kinga Duszyc
  • Suzie Verma
  • Robert G. Parton
  • Srikanth Budnar

Best Publications

  • Molecular and functional analysis of cadherin-based adherens junctions

    Alpha S. Yap;William M. Brieher;Barry M. Gumbiner

  • Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

    A Jeanes;C J Gottardi;A S Yap

  • The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120ctn

    Alpha S. Yap;Carien M. Niessen;Barry M. Gumbiner

  • Recycling of E-cadherin: a potential mechanism for regulating cadherin dynamics.

    Tam Luan Le;Alpha S. Yap;Jennifer L. Stow

  • E-cadherin junctions as active mechanical integrators in tissue dynamics

    Thomas Lecuit;Alpha S. Yap

  • Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation

    Carien M. Niessen;Deborah Leckband;Alpha S. Yap

  • Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

    Dave Boucher;Mercedes Monteleone;Rebecca C. Coll;Kaiwen W. Chen

  • Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function

    Alpha S. Yap;William M. Brieher;Martin Pruschy;Barry M. Gumbiner

  • Myosin 2 Is a Key Rho Kinase Target Necessary for the Local Concentration of E-Cadherin at Cell–Cell Contacts

    Annette M. Shewan;Madhavi Maddugoda;Astrid Kraemer;Samantha J. Stehbens

  • Lateral dimerization is required for the homophilic binding activity of C-cadherin

    William M. Brieher;Alpha S. Yap;Barry M. Gumbiner

  • E-cadherin Homophilic Ligation Directly Signals through Rac and Phosphatidylinositol 3-Kinase to Regulate Adhesive Contacts

    Eva M. Kovacs;Radiya G. Ali;Ailsa J. McCormack;Alpha S. Yap

  • Cadherin-directed actin assembly: E-cadherin physically associates with the Arp2/3 complex to direct actin assembly in nascent adhesive contacts.

    Eva M. Kovacs;Marita K. Goodwin;Radiya G. Ali;Andrew D. Paterson

  • Direct cadherin-activated cell signaling: a view from the plasma membrane.

    Alpha S. Yap;Eva M. Kovacs

  • Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens.

    Michael Smutny;Hayley L. Cox;Joanne M. Leerberg;Eva M. Kovacs

  • Tensile Forces and Mechanotransduction at Cell-Cell Junctions.

    Guillaume Charras;Guillaume Charras;Alpha S. Yap

  • Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens

    Aparna Ratheesh;Guillermo A. Gomez;Rashmi Priya;Suzie Verma

  • Making and breaking contacts: the cellular biology of cadherin regulation

    Alpha S Yap;Matthew S Crampton;Jeff Hardin

  • Cortical F-actin stabilization generates apical–lateral patterns of junctional contractility that integrate cells into epithelia

    Selwin K. Wu;Guillermo A. Gomez;Magdalene Michael;Suzie Verma

  • Contact inhibition (of proliferation) redux.

    Andrea I. McClatchey;Alpha S. K. Yap

  • Autosomal dominant primary hyperparathyroidism and jaw tumor syndrome associated with renal hamartomas and cystic kidney disease: linkage to 1q21-q32 and loss of the wild type allele in renal hamartomas.

    Bin Tean Teh;F. Farnebo;U. Kristoffersson;B. Sundelin

Frequent Co-Authors

Robert G. Parton
Robert G. Parton University of Queensland
Benjamin M. Hogan
Benjamin M. Hogan University of Melbourne
Jennifer L. Stow
Jennifer L. Stow University of Queensland
Anna Akhmanova
Anna Akhmanova Utrecht University
Ygal Haupt
Ygal Haupt Peter MacCallum Cancer Centre
Charles Ferguson
Charles Ferguson University of Queensland
Roger J. Daly
Roger J. Daly Monash University
Benoit Ladoux
Benoit Ladoux Université Paris Cité
Robin L. Anderson
Robin L. Anderson La Trobe University
Stephen B. Fox
Stephen B. Fox Peter MacCallum Cancer Centre

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