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Andrew P. Kowalczyk

Andrew P. Kowalczyk

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
9225
World Ranking
16250
National Ranking
6730

Overview

Andrew P. Kowalczyk is affiliated with Emory University in the United States and specializes in research spanning biochemistry, genetics, molecular biology, and medicine. Their scientific inquiry predominantly focuses on cell biology and molecular biology, with additional engagement in pathology, forensic medicine, immunology, allergy, and rheumatology.

The main research topics addressed in Kowalczyk's work include:

  • Wnt/β-catenin signaling in development and cancer
  • Cellular mechanics and interactions
  • Skin and cellular biology research
  • Hippo pathway signaling and YAP/TAZ
  • Cellular transport and secretion
  • Autoimmune bullous skin diseases
  • Endoplasmic reticulum stress and disease

They have authored numerous papers, including the following recent publications:

  • VE-cadherin endocytosis controls vascular integrity and patterning during development, 2020, The Journal of Cell Biology
  • Architecture and dynamics of a desmosome-endoplasmic reticulum complex, 2023, Nature Cell Biology
  • The desmosome as a model for lipid raft driven membrane domain organization, 2020, Biochimica et Biophysica Acta (BBA) - Biomembranes
  • Protein exchange is reduced in calcium-independent epithelial junctions, 2020, The Journal of Cell Biology
  • Desmosomes undergo dynamic architectural changes during assembly and maturation, 2022, Tissue Barriers

Kowalczyk frequently publishes in various scientific venues. The most common journals include:

  • Journal of Investigative Dermatology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Cell Biology
  • Nature Cell Biology
  • Journal of Cell Science

The scientist collaborates regularly with other researchers, with notable frequent co-authors being:

  • W. Giang
  • Navaneetha Krishnan Bharathan
  • Stephanie Zimmer
  • Alexa L. Mattheyses
  • Tadahiko Seo

Best Publications

  • Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells

    Kanyan Xiao;David F. Allison;Kathleen M. Buckley;Margaret D. Kottke

  • p120-Catenin Regulates Clathrin-dependent Endocytosis of VE-Cadherin

    Kanyan Xiao;Jennifer Garner;Kathleen M. Buckley;Peter A. Vincent

  • The Amino-terminal Domain of Desmoplakin Binds to Plakoglobin and Clusters Desmosomal Cadherin–Plakoglobin Complexes

    Andrew P. Kowalczyk;Elayne A. Bornslaeger;Jeffrey E. Borgwardt;Helena L. Palka

  • Desmosomes: intercellular adhesive junctions specialized for attachment of intermediate filaments.

    Andrew P. Kowalczyk;Elayne A. Bornslaeger;Suzanne M. Norvell;Helena L. Palka

  • Structure, Function, and Regulation of Desmosomes

    Andrew P. Kowalczyk;Kathleen J. Green

  • The desmosome: cell science lessons from human diseases.

    Margareth D. Kottke;Emmanuella Delva;Andrew P. Kowalczyk

  • Desmoglein Endocytosis and Desmosome Disassembly Are Coordinated Responses to Pemphigus Autoantibodies

    Cathárine C. Calkins;Shannon V. Setzer;Jean Marie Jennings;Susan Summers

  • VE-cadherin: adhesion at arm's length.

    Peter A. Vincent;Kanyan Xiao;Kathleen M. Buckley;Andrew P. Kowalczyk

  • p120-catenin binding masks an endocytic signal conserved in classical cadherins.

    Benjamin A. Nanes;Christine Chiasson-MacKenzie;Anthony M. Lowery;Noboru Ishiyama

  • The Head Domain of Plakophilin-1 Binds to Desmoplakin and Enhances Its Recruitment to Desmosomes IMPLICATIONS FOR CUTANEOUS DISEASE

    Andrew P. Kowalczyk;Mechthild Hatzfeld;Elayne A. Bornslaeger;Daniel S. Kopp

  • Mechanisms of VE-cadherin processing and degradation in microvascular endothelial cells.

    Kanyan Xiao;David F. Allison;Margaret D. Kottke;Susan Summers

  • The Endo-Lysosomal Sorting Machinery Interacts with the Intermediate Filament Cytoskeleton

    Melanie L. Styers;Gloria Salazar;Rachal Love;Andrew A. Peden

  • VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: A pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions

    Andrew P. Kowalczyk;Pilar Navarro;Elisabetta Dejana;Elayne A. Bornslaeger

  • Role of p120-catenin in cadherin trafficking.

    Kanyan Xiao;Rebecca G. Oas;Christine M. Chiasson;Andrew P. Kowalczyk

  • Regulation of cadherin trafficking.

    Emmanuella Delva;Andrew P. Kowalczyk

  • Adherens junction turnover: regulating adhesion through cadherin endocytosis, degradation, and recycling.

    Andrew P. Kowalczyk;Benjamin A. Nanes

  • Plakophilin 1 interferes with plakoglobin binding to desmoplakin, yet together with plakoglobin promotes clustering of desmosomal plaque complexes at cell-cell borders.

    Elayne A. Bornslaeger;Lisa Marie Godsel;Connie M. Corcoran;Jung K. Park

  • Regulation of endothelial barrier function and growth by VE-cadherin, plakoglobin, and β-catenin

    Kala Venkiteswaran;Kanyan Xiao;Susan Summers;Cathárine C. Calkins

  • p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation.

    Pilar Alcaide;Gail Newton;Scott Auerbach;Seema Sehrawat

  • Protecting your tail: regulation of cadherin degradation by p120-catenin.

    Andrew P Kowalczyk;Albert B Reynolds

Frequent Co-Authors

Kathleen J. Green
Kathleen J. Green Northwestern University
Victor Faundez
Victor Faundez Emory University
Masayuki Amagai
Masayuki Amagai Keio University
Ilya Levental
Ilya Levental The University of Texas Health Science Center at Houston
Kazuhiko Nakabayashi
Kazuhiko Nakabayashi National Center For Child Health and Development
Akemi Ishida-Yamamoto
Akemi Ishida-Yamamoto Asahikawa Medical University
Yoichi Matsubara
Yoichi Matsubara Tohoku University
Elisabetta Dejana
Elisabetta Dejana Uppsala University
Albert B. Reynolds
Albert B. Reynolds Vanderbilt University
Kathy K. Griendling
Kathy K. Griendling Emory University

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