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Frans van Roy

Frans van Roy

D-Index & Metrics

Molecular Biology

D-Index
77
Citations
30278
World Ranking
1098
National Ranking
14

Overview

Frans van Roy is affiliated with Ghent University in Belgium and specializes in Biochemistry, Genetics, and Molecular Biology, with a focus on molecular biology and genetics. Their work also extends to cellular and molecular neuroscience, cell biology, and developmental neuroscience.

Their research covers several main topics, including:

  • Wnt/β-catenin signaling in development and cancer
  • Cancer-related gene regulation
  • Genetics and neurodevelopmental disorders
  • Neuroscience and neuropharmacology research
  • Axon guidance and neuronal signaling
  • Neurogenesis and neuroplasticity mechanisms
  • Hedgehog signaling pathway studies

Recent publications by van Roy include:

  • Modifying PCDH19 levels affects cortical interneuron migration, 2022, Frontiers in Neuroscience
  • Innovative mouse models for the tumor suppressor activity of Protocadherin-10 isoforms, 2022, BMC Cancer
  • Neural defects caused by total and Wnt1-Cre mediated ablation of p120ctn in mice, 2020, BMC Developmental Biology
  • Plakophilin3 loss leads to increased adenoma formation and rectal prolapse in APCmin mice, 2021, Biochemical and Biophysical Research Communications
  • Diagnosing progressive multifocal leukoencephalopathy: Positive predictive value of CSF JC virus quantitative PCR and importance of recognizing suggestive neuroimaging findings, 2025, Journal of the Neurological Sciences

van Roy frequently collaborates with several co-authors, including:

  • Jolanda van Hengel
  • Anna Pancho
  • Tania Aerts
  • Lieve Geenen
  • Anne Stulens

Their publications regularly appear in scientific venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Neuroscience
  • BMC Cancer
  • Journal of the Neurological Sciences
  • BMC Developmental Biology

Best Publications

  • Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

    K. Vleminckx;L. Vakaet;M. Mareel;W. Fiers

  • The Two-Handed E Box Binding Zinc Finger Protein SIP1 Downregulates E-Cadherin and Induces Invasion

    Joke Comijn;Geert Berx;Petra Vermassen;Kristin Verschueren

  • The cell-cell adhesion molecule E-cadherin

    F. van Roy;G. Berx

  • Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.

    Friedel Nollet;Patrick Kools;Frans van Roy

  • The p300/CBP acetyltransferases function as transcriptional coactivators of β‐catenin in vertebrates

    Andreas Hecht;Kris Vleminckx;Marc P. Stemmler;Frans van Roy

  • The Protein Kinase Akt Induces Epithelial Mesenchymal Transition and Promotes Enhanced Motility and Invasiveness of Squamous Cell Carcinoma Lines

    Sylvia Julien Grille;Alfonso Bellacosa;John Upson;Andres J. Klein-Szanto

  • Mutations of the human E‐cadherin (CDH1) gene

    Geert Berx;Karl-Friedrich Becker;Heinz Höfler;Frans van Roy

  • A novel role for p120 catenin in E-cadherin function.

    Reneé C. Ireton;Michael A. Davis;Jolanda van Hengel;Deborah J. Mariner

  • SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell–cell junctions

    Cindy Vandewalle;Joke Comijn;Bram De Craene;Petra Vermassen

  • The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression

    Geert Berx;Frans Van Roy

  • Molecular evolution of the cadherin superfamily

    Paco Hulpiau;Frans van Roy

  • The role of the ZEB family of transcription factors in development and disease

    C. Vandewalle;F. Van Roy;G. Berx

  • Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition.

    S. Julien;I. Puig;E. Caretti;J. Bonaventure

  • α-Catenin-Vinculin Interaction Functions to Organize the Apical Junctional Complex in Epithelial Cells

    Mitsuko Watabe-Uchida;Naoshige Uchida;Yuzo Imamura;Akira Nagafuchi

  • Predominance of Beta-Catenin Mutations and Beta-Catenin Dysregulation in Sporadic Aggressive Fibromatosis (Desmoid Tumor)

    Sabine Tejpar;Friedel Nollet;Catherine Li;Jay S Wunder

  • β-Catenin Mutations Are More Frequent in Small Colorectal Adenomas Than in Larger Adenomas and Invasive Carcinomas

    Wade S. Samowitz;Michael D. Powers;Lisa N. Spirio;Friedel Nollet

  • Stability of dendritic spines and synaptic contacts is controlled by alpha N-catenin.

    Kentaro Abe;Osamu Chisaka;Frans Van Roy;Masatoshi Takeichi

  • Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.

    Xinyu Chen;Stefan Bonné;Mechthild Hatzfeld;Frans Van Roy

  • A new generation of JASPAR, the open-access repository for transcription factor binding site profiles

    Dominique Vlieghe;Albin Sandelin;Pieter J. De Bleser;Kris Vleminckx

  • Unraveling signalling cascades for the Snail family of transcription factors.

    Bram De Craene;Frans van Roy;Geert Berx

Frequent Co-Authors

Geert Berx
Geert Berx Ghent University
Marc Mareel
Marc Mareel Ghent University Hospital
Philippe Birembaut
Philippe Birembaut University of Reims Champagne-Ardenne
Yvan Saeys
Yvan Saeys Ghent University
Claude Libert
Claude Libert Ghent University
Pierre D. McCrea
Pierre D. McCrea The University of Texas MD Anderson Cancer Center
Albert B. Reynolds
Albert B. Reynolds Vanderbilt University
Riet De Rycke
Riet De Rycke Ghent University
Erik Bruyneel
Erik Bruyneel Ghent University Hospital
Jo Vandesompele
Jo Vandesompele Ghent University

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