Irmgard Merfort mainly focuses on Biochemistry, Stereochemistry, Sesquiterpene, Transcription factor and Pharmacognosy. Her research on Biochemistry often connects related areas such as Piper. Irmgard Merfort has included themes like Polyphenol and Flavones in her Stereochemistry study.
The various areas that Irmgard Merfort examines in her Sesquiterpene study include Supercritical fluid chromatography, Arnica and Lactone. Her Transcription factor study combines topics from a wide range of disciplines, such as Sesquiterpene lactone, Protein subunit, Structure–activity relationship and Cysteine. Her Pharmacognosy research integrates issues from Anti-inflammatory, Traditional medicine, Calendula officinalis, Hypericum perforatum and In vivo.
Her primary scientific interests are in Biochemistry, Stereochemistry, Sesquiterpene, Botany and Flavonoid. As part of her studies on Biochemistry, she frequently links adjacent subjects like Sesquiterpene lactone. Her research in Stereochemistry intersects with topics in Asteraceae and Flavones.
Her biological study spans a wide range of topics, including Chromatography, Quercetin and Polyphenol. Her research in Biological activity focuses on subjects like Anti-inflammatory, which are connected to Traditional medicine and Pharmacognosy. While the research belongs to areas of Transcription factor, Irmgard Merfort spends her time largely on the problem of NF-κB, intersecting her research to questions surrounding Molecular biology.
Irmgard Merfort spends much of her time researching Biochemistry, Pharmacology, Wound healing, Cell biology and Apoptosis. Her study in the field of Cytotoxicity, Endoplasmic reticulum and Docking also crosses realms of EEF2 and SERCA. Her Cytotoxicity research incorporates elements of Sesquiterpene lactone, Cytotoxic T cell, Peripheral blood mononuclear cell and Stereochemistry.
Her Pharmacology study integrates concerns from other disciplines, such as Inflammation, Immunology, Nitric oxide and In vivo. Her Cell signaling and RHOA study in the realm of Cell biology interacts with subjects such as Population. Her Apoptosis study combines topics from a wide range of disciplines, such as Signal transduction and Kinase.
Her scientific interests lie mostly in Pharmacology, Wound healing, Cell biology, Biochemistry and Inflammation. Her Pharmacology research is multidisciplinary, incorporating elements of Chemokine, Extracellular matrix, Hyaluronidase and In vivo. Her studies in In vivo integrate themes in fields like Angiogenesis, Stem cell, Hepatic stellate cell and MAPK/ERK pathway.
Her Wound healing research integrates issues from In vitro and Calendula officinalis, Botany. In the subject of general Cell biology, her work in Cell signaling, RHOA and Intracellular is often linked to Environmental exposure and Translational elongation, thereby combining diverse domains of study. Her research is interdisciplinary, bridging the disciplines of Sesquiterpene lactone and Biochemistry.
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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Patricio Godoy;Nicola J. Hewitt;Ute Albrecht;Melvin E. Andersen.
Archives of Toxicology (2013)
The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65
G Lyss;A Knorre;T J Schmidt;H L Pahl.
Journal of Biological Chemistry (1998)
Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin.
Günter Seelinger;Irmgard Merfort;Christoph M. Schempp.
Planta Medica (2008)
Cysteine 38 in p65/NF-κB Plays a Crucial Role in DNA Binding Inhibition by Sesquiterpene Lactones
Alfonso J. Garcı́a-Piñeres;Vı́ctor Castro;Gerardo Mora;Thomas J. Schmidt.
Journal of Biological Chemistry (2001)
Determination of the wound healing effect of Calendula extracts using the scratch assay with 3T3 fibroblasts.
M. Fronza;B. Heinzmann;M. Hamburger;S. Laufer.
Journal of Ethnopharmacology (2009)
Anti-carcinogenic Effects of the Flavonoid Luteolin
Günter Seelinger;Irmgard Merfort;Ute Wölfle;Christoph M. Schempp.
Inhibition of transcription factor NF-κB by sesquiterpene lactones: a proposed molecular mechanism of action
Peter Rüngeler;Victor Castro;Gerardo Mora;Nezhun Gören.
Bioorganic & Medicinal Chemistry (1999)
Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB
Guido Lyss;Thomas J. Schmidt;Irmgard Merfort;Heike L. Pahl.
Biological Chemistry (1997)
Perspectives on Sesquiterpene Lactones in Inflammation and Cancer
Current Drug Targets (2011)
Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB.
Bettina Siedle;Alfonso J García-Piñeres;Renato Murillo;Jürgen Schulte-Mönting.
Journal of Medicinal Chemistry (2004)
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