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Chih-Chung Lin

Chih-Chung Lin

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
7610
World Ranking
15313
National Ranking
74

Overview

Chih-Chung Lin is affiliated with Chang Gung University in Taiwan. Their research contributions span several scientific fields, with particular focus on immunology and neurology. The scientist's work explores mechanisms at the intersection of neuroinflammation, neurodegeneration, and immune cell interactions.

Their research topics include:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Tryptophan and brain disorders
  • Alzheimer's disease research and treatments
  • Genetics, Aging, and Longevity in Model Organisms
  • Air Quality and Health Impacts
  • Immune Cell Function and Interaction
  • Mast cells and histamine

Key subfields of study for Chih-Chung Lin cover:

  • Immunology
  • Neurology
  • Molecular Biology
  • Biological Psychiatry
  • Polymers and Plastics

The scientist has published research in several specialized venues, including:

  • Aerosol and Air Quality Research
  • Trends in Immunology
  • Nature Neuroscience
  • Advanced Science
  • Cell Reports

Some recent papers authored or co-authored by Chih-Chung Lin are:

  • Mast cell deficiency improves cognition and enhances disease-associated microglia in 5XFAD mice, 2023, Cell Reports
  • Infiltrating CD8+ T cells exacerbate Alzheimer's disease pathology in a 3D human neuroimmune axis model, 2023, Nature Neuroscience
  • Structure-Based Discovery of A Small Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) that Significantly Reduces Alzheimer's Disease Neuropathology, 2023, Advanced Science
  • Transcription Factor Bhlhe40 in Immunity and Autoimmunity, 2020, Trends in Immunology
  • Toxicity of Low-dose Graphene Oxide Nanoparticles in an in-vivo Wild Type of Caenorhabditis elegans Model, 2020, Aerosol and Air Quality Research

Frequent collaborators in their research include:

  • Rudolph E. Tanzi
  • Mehdi Jorfi
  • Sheng-Lun Lin
  • Melissa E. Cook
  • Nicholas N. Jarjour

Best Publications

  • TNF-α induces MMP-9 expression via activation of Src/EGFR, PDGFR/PI3K/Akt cascade and promotion of NF-κB/p300 binding in human tracheal smooth muscle cells

    Chiang-Wen Lee;Chih-Chung Lin;Wei-Ning Lin;Kao-Chih Liang

  • Overexpression of HO-1 Protects against TNF-α-Mediated Airway Inflammation by Down-Regulation of TNFR1-Dependent Oxidative Stress

    I-Ta Lee;Shue Fen Luo;Chiang Wen Lee;Shyi Wu Wang

  • Lipoteichoic acid induces HO-1 expression via the TLR2/MyD88/c-Src/NADPH oxidase pathway and Nrf2 in human tracheal smooth muscle cells.

    I-Ta Lee;Shyi Wu Wang;Chiang Wen Lee;Chia Chi Chang

  • Interleukin-1β induces MMP-9 expression via p42/p44 MAPK, p38 MAPK, JNK, and nuclear factor-κB signaling pathways in human tracheal smooth muscle cells

    Kao-Chih Liang;Chiang-Wen Lee;Wei-Ning Lin;Chih-Chung Lin

  • Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation.

    Chih-Chung Lin;Tara R. Bradstreet;Elizabeth A. Schwarzkopf;Julia Sim

  • Induction of COX-2/PGE2/IL-6 is crucial for cigarette smoke extract-induced airway inflammation: Role of TLR4-dependent NADPH oxidase activation

    Chih-Chung Lin;I-Ta Lee;Ya-Lin Yang;Chiang-Wen Lee

  • Transcriptional regulation of VCAM-1 expression by tumor necrosis factor-alpha in human tracheal smooth muscle cells: involvement of MAPKs, NF-kappaB, p300, and histone acetylation.

    Chiang-Wen Lee;Wei-Ning Lin;Chih-Chung Lin;Shue-Fen Luo

  • Role of TLR4/NADPH oxidase/ROS-activated p38 MAPK in VCAM-1 expression induced by lipopolysaccharide in human renal mesangial cells

    I-Ta Lee;Ruey Horng Shih;Chih Chung Lin;Jung Tsan Chen

  • Cooperation of TLR2 with MyD88, PI3K, and Rac1 in Lipoteichoic Acid–Induced cPLA2/COX-2–Dependent Airway Inflammatory Responses

    I-Ta Lee;Chiang Wen Lee;Wei Hsuan Tung;Shyi Wu Wang

  • Japanese encephalitis virus induces matrix metalloproteinase-9 expression via a ROS/c-Src/PDGFR/PI3K/Akt/MAPKs-dependent AP-1 pathway in rat brain astrocytes.

    Chuen-Mao Yang;Chih-Chung Lin;I-Ta Lee;Yi-Hsin Lin

  • Cigarette smoke particle-phase extract induces HO-1 expression in human tracheal smooth muscle cells: role of the c-Src/NADPH oxidase/MAPK/Nrf2 signaling pathway

    Shin Ei Cheng;I-Ta Lee;Chih Chung Lin;Yu Ru Kou

  • Interleukin-1β induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid arthritis synovial fibroblasts: Involvement of ERK, JNK, AP-1, and NF-κB

    Chuen-Mao Yang;Shue-Fen Luo;Hsi-Lung Hsieh;Pei-Ling Chi

  • P2Y2 receptor-mediated proliferation of C6 glioma cells via activation of Ras/Raf/MEK/MAPK pathway

    Ming-Tze Tu;Shue-Fen Luo;Chuan-Chawn Wang;Chin-Sung Chien

  • IL-1β induces expression of matrix metalloproteinase-9 and cell migration via a c-Src-dependent, growth factor receptor transactivation in A549 cells

    Ching-Yi Cheng;Chang-Ting Kuo;Chih-Chung Lin;Hsi-Lung Hsieh

  • Involvement of p42/p44 MAPK, p38 MAPK, JNK, and NF-κB in IL-1β-induced VCAM-1 expression in human tracheal smooth muscle cells

    Chien-Chun Wang;Wei-Ning Lin;Chiang-Wen Lee;Chih-Chung Lin

  • Mitogenic effect of oxidized low-density lipoprotein on vascular smooth muscle cells mediated by activation of Ras/Raf/MEK/MAPK pathway.

    Chuen-Mao Yang;Chin-Sung Chien;Li-Der Hsiao;Shiow-Lin Pan

  • Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection.

    Jeremy P. Huynh;Chih Chung Lin;Jacqueline M. Kimmey;Nicholas N. Jarjour

  • IL-1β promotes A549 cell migration via MAPKs/AP-1- and NF-κB-dependent matrix metalloproteinase-9 expression

    Chih Chung Lin;Chang Ting Kuo;Ching Yi Cheng;Cheng Ying Wu

  • c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells

    Chun Chou;Amelia K Pinto;Jonathan D Curtis;Stephen P Persaud

  • Involvement of p42/p44 MAPK, JNK, and NF-kappaB in IL-1beta-induced ICAM-1 expression in human pulmonary epithelial cells.

    Feng-Shu Lin;Chih-Chung Lin;Chin-Sung Chien;Shu-Feng Luo

Frequent Co-Authors

Chuen-Mao Yang
Chuen-Mao Yang Chang Gung University
Yuh-Lien Chen
Yuh-Lien Chen National Taiwan University
Tsong-Long Hwang
Tsong-Long Hwang Chang Gung University of Science and Technology
William C. Aird
William C. Aird Beth Israel Deaconess Medical Center
Yang Chang Wu
Yang Chang Wu China Medical University

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