World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
61
Citations
13316
World Ranking
9238
National Ranking
2611

Biology and Biochemistry

D-Index
73
Citations
16857
World Ranking
6019
National Ranking
2840

Research.com Recognitions

  • 2009 - Fellow of the American Chemical Society
  • 2005 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2004 - Fellow of the Indian National Academy of Engineering (INAE)

Overview

Deborah E. Leckband is affiliated with the University of Illinois at Urbana-Champaign in the United States. Their research primarily focuses on fields related to biochemistry, genetics, and molecular biology, with a significant emphasis on cell biology and molecular biology. The scope of their work covers various specialized subfields including atomic and molecular physics, optics, surfaces, coatings, films, immunology, and allergy.

The scientist's research topics encompass several areas such as:

  • Cellular mechanics and interactions
  • Wnt/β-catenin signaling in development and cancer
  • Force microscopy techniques and applications
  • Cell adhesion molecules research
  • Polymer surface interaction studies
  • Hippo pathway signaling and YAP/TAZ
  • Skin and cellular biology research

Frequent publication venues for their work include:

  • Biophysical Journal
  • Biomacromolecules
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Current Opinion in Biomedical Engineering

Several coauthors have collaborated regularly with Deborah E. Leckband, including:

  • Vinh H. Vu
  • Brendan Sullivan
  • Daniel K. Schwartz
  • Gregory J. Schwarz
  • Taylor P. Light

Notable recent papers include:

  • "Mechanical disruption of E-cadherin complexes with epidermal growth factor receptor actuates growth factor-dependent signaling", 2022, Proceedings of the National Academy of Sciences
  • "Cadherin cis and trans interactions are mutually cooperative", 2021, Proceedings of the National Academy of Sciences
  • "Protein Adsorption on Grafted Zwitterionic Polymers Depends on Chain Density and Molecular Weight", 2020, Advanced Functional Materials
  • "Cadherin clusters stabilized by a combination of specific and nonspecific cis-interactions", 2020, eLife
  • "P120 catenin potentiates constitutive E-cadherin dimerization at the plasma membrane and regulates trans binding", 2021, Current Biology

Deborah E. Leckband has been recognized with several awards, including:

  • Fellow of the American Chemical Society, 2009
  • Fellow of the American Association for the Advancement of Science (AAAS), 2005
  • Fellow of the Indian National Academy of Engineering (INAE), 2004

Best Publications

  • Intermolecular forces in biology.

    Deborah Leckband;Jacob Israelachvili

  • Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner.

    Quint le Duc;Quanming Shi;Iris Blonk;Arnoud Sonnenberg

  • Measuring the forces that control protein interactions.

    Deborah Leckband

  • PNIPAM chain collapse depends on the molecular weight and grafting density.

    Kyle N. Plunkett;Xi Zhu;Jeffrey S. Moore;Deborah E. Leckband

  • Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation

    Carien M. Niessen;Deborah Leckband;Alpha S. Yap

  • Cadherin Adhesion and Mechanotransduction

    Deborah E Leckband;J. de Rooij

  • Development and characterization of an ELISA assay in PDMS microfluidic channels

    E Eteshola;D Leckband

  • Modulation of interaction forces between bilayers exposing short-chained ethylene oxide headgroups.

    T.L. Kuhl;D.E. Leckband;D.D. Lasic;J.N. Israelachvili

  • Grafted poly(ethylene oxide) brushes as nonfouling surface coatings.

    Deborah E Leckband;S. Sheth;A. Halperin

  • Measurements of attractive forces between proteins and end-grafted poly(ethylene glycol) chains

    S. R. Sheth;Deborah E Leckband

  • A quantitative assessment of heterogeneity for surface-immobilized proteins.

    Ravi A. Vijayendran;Deborah E. Leckband

  • Direct evidence that neural cell adhesion molecule (NCAM) polysialylation increases intermembrane repulsion and abrogates adhesion.

    Colin P. Johnson;Ichiro Fujimoto;Urs Rutishauser;Deborah E. Leckband

  • Mechanism and dynamics of cadherin adhesion.

    Deborah E Leckband;Anil Prakasam

  • Long-term stability of grafted polyethylene glycol surfaces for use with microstamped substrates in neuronal cell culture.

    Darren W. Branch;Bruce C. Wheeler;Gregory J. Brewer;Deborah E. Leckband

  • DIRECT FORCE MEASUREMENTS OF SPECIFIC AND NONSPECIFIC PROTEIN INTERACTIONS

    D. E. Leckband;F. J. Schmitt;J. N. Israelachvili;Wolfgang Knoll

  • Chain-length dependence of the protein and cell resistance of oligo(ethylene glycol)-terminated self-assembled monolayers on gold

    Boru Zhu;Thomas Eurell;Rico Gunawan;Deborah Leckband

  • Higher order self-assembly of vesicles by site-specific binding

    Shivkumar Chiruvolu;Scott Walker;Jacob Israelachvili;Franz Josef Schmitt

  • Direct Measurement of Polyethylene Glycol Induced Depletion Attraction between Lipid Bilayers

    Tonya Kuhl;Yuqing Guo;James L. Alderfer;Alan D. Berman

  • Long-term maintenance of patterns of hippocampal pyramidal cells on substrates of polyethylene glycol and microstamped polylysine

    D.W. Branch;B.C. Wheeler;G.J. Brewer;D.E. Leckband

  • Mechanotransduction at cadherin-mediated adhesions

    Deborah E Leckband;Quint le Duc;Ning Wang;Johan de Rooij

  • Direct Molecular Force Measurements of Multiple Adhesive Interactions between Cadherin Ectodomains

    S. Sivasankar;W. Brieher;W. Brieher;N. Lavrik;B. Gumbiner

Frequent Co-Authors

Jacob N. Israelachvili
Jacob N. Israelachvili University of California, Santa Barbara
Ning Wang
Ning Wang University of Illinois at Urbana-Champaign
Daniel K. Schwartz
Daniel K. Schwartz University of Colorado Boulder
Urs Rutishauser
Urs Rutishauser Memorial Sloan Kettering Cancer Center
Cara J. Gottardi
Cara J. Gottardi Northwestern University
Pierre Bongrand
Pierre Bongrand Aix-Marseille University
En-Tang Kang
En-Tang Kang National University of Singapore
Koon Gee Neoh
Koon Gee Neoh National University of Singapore
Paul J. A. Kenis
Paul J. A. Kenis University of Illinois at Urbana-Champaign
Nickolay V. Lavrik
Nickolay V. Lavrik Oak Ridge National Laboratory

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