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Molecular Biology

D-Index
74
Citations
23893
World Ranking
1219
National Ranking
631

Overview

Paul A. Wade is affiliated with the National Institutes of Health in the United States. Their research is primarily situated within the field of Biochemistry, Genetics, and Molecular Biology, with a focus on several specialized subfields. These include Molecular Biology, Pulmonary and Respiratory Medicine, Cancer Research, Surgery, and Plant Science.

The scientist's main topics of study encompass Epigenetics and DNA Methylation, Genomics and Chromatin Dynamics, RNA modifications and cancer, Cancer-related gene regulation, Cancer Genomics and Diagnostics, Single-cell and spatial transcriptomics, and Chromatin Remodeling and Cancer.

Paul A. Wade has contributed to multiple recent papers across high-impact scientific journals. Key works include:

  • Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms (2020, Nature Communications)
  • DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation (2021, Nature Communications)
  • Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation (2020, Proceedings of the National Academy of Sciences)
  • Interaction of the pioneer transcription factor GATA3 with nucleosomes (2020, Nature Communications)
  • Alterations in promoter interaction landscape and transcriptional network underlying metabolic adaptation to diet (2020, Nature Communications)

The scientist frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Nucleic Acids Research, UNC Libraries, and Cell Reports Methods. These publication outlets reflect a broad engagement with molecular and genetic biology research.

Collaboration is a notable aspect of Paul A. Wade's work. Frequent co-authors include Sara A. Grimm, Gang Greg Wang, Linfeng Gao, Yiran Guo, and Wendan Ren, indicating active partnerships within their research community.

Best Publications

  • Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription.

    Peter L. Jones;Gert C. Jan Veenstra;Paul A. Wade;Danielle Vermaak

  • DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

    Keith D. Robertson;Slimane Ait-Si-Ali;Tomoki Yokochi;Paul A. Wade

  • Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation.

    Paul A. Wade;Anne Gegonne;Peter L. Jones;Esteban Ballestar

  • Rhythmic histone acetylation underlies transcription in the mammalian circadian clock

    Jean Pierre Etchegaray;Choogon Lee;Paul A. Wade;Steven M. Reppert

  • MTA3, a Mi-2/NuRD Complex Subunit, Regulates an Invasive Growth Pathway in Breast Cancer

    Naoyuki Fujita;David L. Jaye;Masahiro Kajita;Cissy Geigerman

  • The human Mi-2/NuRD complex and gene regulation

    S A Denslow;P A Wade

  • Histone acetylation: chromatin in action

    Paul A. Wade;Dmitry Pruss;Alan P. Wolffe

  • A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase

    Paul A. Wade;Peter L. Jones;Danielle Vermaak;Alan P. Wolffe

  • Cancer biology and NuRD: a multifaceted chromatin remodelling complex

    Anne Y. Lai;Paul A. Wade

  • Methyl CpG-binding proteins and transcriptional repression.

    Paul A. Wade

  • Aberrant expression of the transcription factors Snail and Slug alters the response to genotoxic stress

    Masahiro Kajita;Karissa N. McClinic;Paul A. Wade

  • Transcriptional control at regulatory checkpoints by histone deacetylases: molecular connections between cancer and chromatin

    Paul A. Wade

  • MTA3 and the Mi-2/NuRD Complex Regulate Cell Fate during B Lymphocyte Differentiation

    Naoyuki Fujita;David L. Jaye;Cissy Geigerman;Adil Akyildiz

  • Chromatin Compaction by Human MeCP2 ASSEMBLY OF NOVEL SECONDARY CHROMATIN STRUCTURES IN THE ABSENCE OF DNA METHYLATION

    Philippe T. Georgel;Philippe T. Georgel;Rachel A. Horowitz-Scherer;Nick Adkins;Christopher L. Woodcock

  • Mi-2/NuRD: multiple complexes for many purposes

    Nathan J Bowen;Naoyuki Fujita;Masahiro Kajita;Paul A Wade

  • Generation of superhelical torsion by ATP-dependent chromatin remodeling activities.

    Kristina Havas;Andrew Flaus;Michael Phelan;Robert Kingston

  • WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.

    Ludmila Bozhenok;Paul A. Wade;Patrick Varga‐Weisz

  • The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties

    Mario F. Fraga;Esteban Ballestar;Guillermo Montoya;Panya Taysavang

  • Active Remodeling of Somatic Nuclei in Egg Cytoplasm by the Nucleosomal ATPase ISWI

    Nobuaki Kikyo;Paul A. Wade;Dmitry Guschin;Hui Ge

  • Methyl CpG binding proteins: coupling chromatin architecture to gene regulation.

    Paul A Wade

Frequent Co-Authors

Alan P. Wolffe
Alan P. Wolffe Sangamo BioSciences (United States)
Hitoshi Kurumizaka
Hitoshi Kurumizaka University of Tokyo
John Roberts
John Roberts Rice University
Han G. Brunner
Han G. Brunner Radboud University
Simon E. Fisher
Simon E. Fisher Max Planck Society
Caroline Nava
Caroline Nava Université Paris Cité
Trevor K. Archer
Trevor K. Archer National Institutes of Health
Tjitske Kleefstra
Tjitske Kleefstra Erasmus University Rotterdam
Yinsheng Wang
Yinsheng Wang University of California, Riverside
Tatiana G. Kutateladze
Tatiana G. Kutateladze University of Colorado Denver

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