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Biology and Biochemistry

D-Index
72
Citations
20473
World Ranking
6241
National Ranking
151

Overview

Assam El-Osta is affiliated with Monash University in Australia and has a research profile spanning biochemistry, genetics, molecular biology, and medicine. Their work covers a range of subfields including molecular biology, genetics, surgery, physiology, and immunology.

Their research topics include epigenetics and DNA methylation, pancreatic function and diabetes, genetics and neurodevelopmental disorders, diet and metabolism studies, diabetes management and research, diabetes and associated disorders, and gut microbiota and health.

Frequent co-authors in their research include Ishant Khurana, Jun Okabe, Scott Maxwell, Harikrishnan Kaipananickal, and Keith Al-Hasani.

El-Osta has published extensively in several scientific venues with multiple publications noted in Cellular and Molecular Life Sciences, Journal of the American Society of Nephrology, Circulation Research, Signal Transduction and Targeted Therapy, and Clinical Epigenetics.

Selected recent papers by Assam El-Osta and their details include:

  • Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease, 2020, Circulation
  • The ILAE consensus classification of focal cortical dysplasia: An update proposed by an ad hoc task force of the ILAE diagnostic methods commission, 2022, Epilepsia
  • Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis, 2020, Circulation Research
  • The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan, 2020, Cell Reports
  • Processed foods drive intestinal barrier permeability and microvascular diseases, 2021, Science Advances

Best Publications

  • γH2AX: a sensitive molecular marker of DNA damage and repair

    Mah Lj;El-Osta A;El-Osta A;Karagiannis Tc;Karagiannis Tc

  • Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

    Assam El-Osta;Daniella Brasacchio;Dachun Yao;Alessandro Pocai

  • High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice.

    Francine Z. Marques;Erin M. Nelson;Po-Yin Chu;Duncan Horlock

  • Microparticles: major transport vehicles for distinct microRNAs in circulation

    Philipp Diehl;Philipp Diehl;Alba Fricke;Laura Sander;Johannes Stamm

  • Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

    Daniella Brasacchio;Jun Okabe;Christos Tikellis;Aneta Balcerczyk

  • NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis

    Stephen P. Gray;Elyse Di Marco;Jun Okabe;Cedric Szyndralewiez

  • Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing.

    KN Harikrishnan;Maggie Z Chow;Emma K Baker;Sharmistha Pal

  • Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

    Jay Chandra Jha;Jay Chandra Jha;Stephen Peter Gray;David Barit;Jun Okabe

  • The Circadian Syndrome: is the Metabolic Syndrome and much more!

    P. Zimmet;K. G. M. M. Alberti;N. Stern;C. Bilu

  • Modulation of Soluble Receptor for Advanced Glycation End Products by Angiotensin-Converting Enzyme-1 Inhibition in Diabetic Nephropathy

    Josephine M. Forbes;Suzanne R. Thorpe;Vicki Thallas-Bonke;Josefa Pete

  • Clonogenic assay: adherent cells

    Haloom Rafehi;Christian Orlowski;Christian Orlowski;George T. Georgiadis;Katherine Ververis;Katherine Ververis

  • Epigenetics and metabolism.

    Samuel T. Keating;Assam El-Osta

  • Epigenetic phenomena linked to diabetic complications

    Luciano Pirola;Aneta Balcerczyk;Jun Okabe;Assam El-Osta

  • Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs.

    Emma K Baker;Ricky W Johnstone;John R Zalcberg;Assam El-Osta

  • Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease

    David M. Kaye;David M. Kaye;Waled A. Shihata;Hamdi A. Jama;Kirill Tsyganov

  • Precipitous Release of Methyl-CpG Binding Protein 2 and Histone Deacetylase 1 from the Methylated Human Multidrug Resistance Gene (MDR1) on Activation

    Assam El-Osta;Phillip Kantharidis;John R. Zalcberg;Alan P. Wolffe

  • Epigenetics: Mechanisms and Implications for Diabetic Complications

    Mark E. Cooper;Assam El-Osta

  • Multicellular Transcriptional Analysis of Mammalian Heart Regeneration.

    Gregory A. Quaife-Ryan;Choon Boon Sim;Mark Ziemann;Antony Kaspi

  • Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells

    Luciano Pirola;Aneta Balcerczyk;Richard W. Tothill;Izhak Haviv

  • Poster: Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail

    Assam El-Osta;Assam El-Osta

Frequent Co-Authors

Mark E. Cooper
Mark E. Cooper Monash University
Paul Zimmet
Paul Zimmet Monash University
David M. Kaye
David M. Kaye The Alfred Hospital
Murray D. Esler
Murray D. Esler Baker IDI Heart and Diabetes Institute
Mimi L.K. Tang
Mimi L.K. Tang Royal Children's Hospital
Anthony M. Dart
Anthony M. Dart Monash University
Charles R. Mackay
Charles R. Mackay Qilu University of Technology
Josephine M. Forbes
Josephine M. Forbes University of Queensland
Gavin W. Lambert
Gavin W. Lambert Swinburne University of Technology
Ross Lazarus
Ross Lazarus Baker IDI Heart and Diabetes Institute

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